Organic compounds -- part of the class 532-570 series inventions 08/06

20060189813 - Novel method for the synthesis of perinidopril and the pharmaceutically acceptable salts thereof: P

20060189814 - Process for the synthesis of peptides containing a 4-hydroxy-proline substructure:

20060183913 - Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds,...

20060183912 - Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds,...

20060183914 - Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles: s

20060183915 - Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles:

20060183916 - Process for the preparation of phenyltetrazole derivatives: A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-γl)benzene. The compounds of formula (II) are useful intermediates for the preparation of angiotensin II antagonists....

20060183917 - Processes and compounds for the preparation of substituted naphthylindole derivatives: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or...

20060183918 - Beta 2-adrenergic receptor agonists: Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor....

20060183920 - Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof: s

20060183919 - Novel method for the synthesis of s-indoline-2- carboxylic acid and application thereof in the synthesis of perindopril:

20060173190 - Nematicidal thiazoline-containing fluorobutenes: P

20060173191 - Transesterification process for production of (meth)acrylate ester monomers: This invention utilizes multiple charges of a transesterification catalyst in a transesterification process for the production of esters of alkyl (meth)acrylate monomers. The multiple catalyst charge addition strategy and reaction conditions provide for higher productivity and enhanced consistency....

20060173192 - Aminoalkylphenyl indolone derivatives: This invention is directed to aminoalkylphenyl indolone derivatives which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective...

20060173193 - N-arylsulfonyl-3-aminoalkoxyindoles: N-arylsulfonyl-3-aminoalkoxyindoles indole compounds, radioisotopes, stereoisomers, geometric forms, N-oxides, polymorphs and pharmaceutically acceptable salts....

20060173194 - Method for crystallizing n-vinyl-2-pyrrolidone: A method for purifying N-vinyl-2-pyrrolidone (NVP) is disclosed. The method comprises crystallizing NVP in the presence of added water to produce purified NVP crystals and a mother liquor, and then isolating the purified crystals. In a preferred method, 0.5 to 4 wt. % of water based on the amount of...

20060173195 - Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals,...