Organic compounds -- part of the class 532-570 series inventions 05/06

20060111572 - Ligands and complex compounds containing the same: wherein Q3 is an optionally substituted alkylene group, an optionally substituted cycloalkylene group, an optionally substituted arylene group, or an optionally substituted divalent heterocyclic group, R5 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group and R6 is a substituent which may...

20060111573 - Resolution of mefloquine with o,o-di-p-aroyltartaric acid: A process for increasing the optical purity of a mixture of enantiomers of mefloquine, used a substantially single entantiomer of a O,O-di-p-aroyltartaric acid as a resolving agent....

20060106219 - Chemical process: The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of...

20060106220 - Compositions and therapeutic methods involving isoflavones and analogues thereof: Isoflavone compounds and analogues thereof, compositions containing same and therapeutic methods of treatment involving same are described....

20060106221 - Process for the preparation of thiazolidinedione derivatives: wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I)....

20060106222 - Aminoadamantane derivatives as therapeutic agents: The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions There are a variety of neurological disorders that can be treated using the present invention, including, for...

20060106223 - Cyanation of aromatic halides: A practical, ligand-free cyanation of aryl bromides employs Pd catalyst in combination with a non-toxic cyanide source, Mn[Fe(CN)6] (M=K or Na; n is 3 or 4), or a hydrate thereof, and a base. The reactions are performed in a polar aprotic solvents and provide the corresponding aryl nitrile in 83-96%...

20060100433 - n-conjugated organic material of polycyclic fused ring type,intermediate therefor, and process for producing n-conjugated organic material of polycyclic fused ring type: The invention provides condensed polycyclic π-conjugated organic materials and manufacturing methods for the materials. A metal reducing agent is reacted with a straight-chain, triple bond-containing hydrocarbon (aryl acetylene compound, phenyl acetylene compound), the hydrocarbon being a benzene ring with an organic silicon as a substituent, so as to allow an...

20060100434 - Method for introducing a 1,2-double bond into 3-oxo-4-azasteroid compounds: e

20060100435 - Process for the production of desloratadine: An improved process for the production of Desloratadine is described wherein Loratadine is reacted with neat alcohol in presence of inorganic base, followed by isolating Desloratadine on addition of excess water in crystalline form....

20060100436 - Antimicrobial quinolones, their compositions, and uses: wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from...

20060100437 - Process for producing carbostyril derivatives: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a...

20060100438 - Process of making fentanyl intermediates: Disclosed are processes of making the fentanyl intermediate 1-(2-phenethyl)-4-anilinopiperidine. Also disclosed are methods of isolating the compound....

20060100439 - Process for the preparation of modification i of n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide: The invention relates to a new process for the preparation of modification I of torasemide by precipitation with acids from an alkaline extract of the original reaction mixture of the last phase in the synthesis of torasemide....

20060100440 - Process for the preparation of isonicotinic acid derivatives: and pharmaceutically acceptable additional salts thereof, wherein R is lower alkyl. The compounds of formula Ia or Ib are valuable intermediate products for the manufacture of compounds that are pharmaceutically active as adenosine A2a receptor antagonist or metabotropic Glutamate receptor 2 antagonist. Such compounds are important in the regulation of...

20060100441 - Process for the preparation of 2-aminomethylpyridine derivative: Process for the preparation of 2-aminomethylpyridine derivative of general formula (I), in which: n represents 0, 1, 2 or 3; X is halogen atom; Y may be the same or different and may be a halogen atom, a halogenoalkyl, a alkoxycarbonyl or a alkylsulphonyl....

20060094875 - Platinum complexes: wherein any two of A, B and C are each independently an optionally substituted nitrogenous aromatic heterocyclic group and the other is optionally substituted aryl or optionally substituted heteroaryl; and Y is halogeno or an optionally substituted aryl or heteroaryl group which is bonded either directly or through oxygen (—O—)...

20060094876 - Process for making camptothecin derivatives: A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin....

20060094877 - Process for preparation of benzylpiperidine compounds: p

20060094878 - Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds: Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processes are useful as muscarinic receptor antagonists....

20060094879 - New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents: o

20060094880 - Synthetic process for trans-aminocyclohexyl ether compounds: wherein R3, R4 and R5 are independently bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, cyano, sulfamyl, trifluoromethyl, C2-C7alkanoyloxy, C1-C6alkyl, C1-C6alkoxy, C2-C7alkoxycarbonyl, C1-C6thioalkyl, aryl or N(R6,R7) where R6 and R7 are independently hydrogen, acetyl, methanesulfonyl or C1-C6alkyl; or R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6alkoxy; with...

20060094881 - Methods of preparing indazole compounds: e

20060094882 - Ambient-temperature molten salts and process for producing the same: wherein Y+ is a cation selected from the group consisting of an ammonium ion, a sulfonium ion, a pyridinium ion, a(n) (iso)thiazolium ion, and a(n) (iso)oxazolium ion that may be optionally substituted with C1-10 alkyl and/or C1-10 alkyl having ether linkage, provided that the above cation has at least one...