Organic compounds -- part of the class 532-570 series inventions 04/06

20060084805 - Synthesis of thienopyridinone compounds and related intermediates: The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux...

20060084806 - Processes for the preparation of imidazo[1,2-a] pyridine derivatives: wherein R, R3 and R4 have the aforestated meanings with a halogenating agent in the absence of a solvent to form an acid halide intermediate and (b) reacting the acid halide intermediate with an amine of the formula HNR1R2 wherein R1 and R2 have the aforestated meanings to form the...

20060084807 - Novel denzamide derivatives and process for production thereof: There are provided a novel process for the production of an isoquinoline derivative having an inhibitory action for If current; a novel benzamide derivative or a salt thereof used for the production process; and a process for the production of the benzamide derivative or a salt thereof....

20060084808 - Process for producing cyanopiperidine: The present invention relates to an improved and single step process for producing cyanopiperidine by dehydrating respective piperidine carboxamide employing a suitable dehydrating agent....

20060084809 - Compounds as pde iv and tnf-inhibitors: This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a...

20060084810 - Antibacterial 1,3-oxazolidin-2-one derivatives: Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N-HET is for example triazolyl substituted with R1; R1 is for example optionally substituted (1-4C)alkyl; Q is for example phenyl or pyridyl, substituted with T; T is for example selected from (TAa1 to TAa12) such as...

20060084811 - Method for the synthesis of a benzimidazole compound: A process for the manufacture of omeprazole or esomeprazole from pyrmethyl alcohol via pyrmethyl chloride and pyrmetazole characterized in that the whole reaction sequence is carried out without any isolation or purification of intermediates. Further, the reaction is carried out in a solvent system common for the whole reaction sequence...

20060084812 - Purification of impure materials using non-aqueous solvents: An improved process for improving the purity of an impure material, for example for producing low color nicotine is disclosed. The process involves passing a solution of less pure material, for example nicotine, in a non-aqueous solvent, such as a fluorinated hydrocarbon, for example tetrafluoroethane, through an ion exchange resin...

20060084813 - Method for producing alkenone ethers: In a method or producing haloalkenone ethers by addition of a carboxylic acid halide to a vinyl ether and subsequent elimination of hydrogen halide, the improvement comprising carrying out the reaction in the absence of a base and/or in the presence of a stabilizer for the resulting alkenone, whereby higher...

20060079690 - Processes for preparing 7-hydroxy-3,4-dihydro-2(1h)-quinolinone and the use in aripiprazole preparation thereof: The present invention provides improved processes for preparing the intermediate 7-hydroxy-3,4-dihydro-2(1H)-quinolinone (7-HQ), which may be used in preparing the drug aripiprazole. Among these processes are included three efficient processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone comprising reacting N-(3-methoxyphenyl)-3-chloropropionamide with AlCl3 using novel reaction conditions thus obtaining a substantially pure product, which may be...

20060074239 - Method for the catalytic production of hydrocodone and hydromorphone: A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal complex of a tertiary phosphine halide as catalyst....

20060074240 - Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline: m

20060074241 - Enantioselective process:

20060074242 - Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form i: The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation...

20060074243 - Hydroxamic acid and amide compounds and their use as protease inhibitors: wherein A1, A2, A3, E1, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly...

20060074244 - Pyridinyl substituted (1,2,3,)triazoles as inhibitors of the tgf-beta signalling pathway: The invention relates to novel triazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and...

20060074245 - Method for preparation of n-pyrazolylamidoximes: e