Organic compounds -- part of the class 532-570 series inventions 04/06

20060089493 - Novel gene targets and ligands that bind thereto for treatment and diagnosis of colon carcinomas: Nucleic acids and proteins that are overexpressed in colon or colorectal tumor tissues, and which are useful diagnostic and therapeutic targets....

20060089494 - Method for preparing oligonucleotides: A method for preparing an oligonucleotide comprising the steps of a) providing a 3-protected compound having the formula: wherein B is a heterocyclic base R2 is H, a protected 2-hydroxyl group, F, a protected amino group, an O-alkyl group, an O-substituted alkyl, a substituted alkylamino or a C4′-O2′methylen linkage R3...

20060084795 - Substituted 9a-n-[n'-(benzenesulfonyl)carbamoyl-aminopropyl]and 9a-n-[n'-(b-cya-neothyl) -n-[n'-(benzenesulfonyl)carbamoyl-y-aminopropyl]derivatives of 9-deoxo-9-dihydro-9a-aza- 9a-homoerithromycin a and 5-0-aza-homoerithronolide a: The invention relates to substituted 9a-N-{N′-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5-0-desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide A, novel semisynthetic macrolide antibiotics of the azalide series general formula (1), wherein R represents H or cladinosyl moiety and R1 represents chloro, amino, phenylamino, 2-pyridylamino, 3,4-dimethyl-4-isoxalylamino and 5-methyl-3-isoxazolylamino group, and pharmaceutically acceptable addition salts thereof with inorganic...

20060084798 - Cdnas and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use: The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are α-class hypoxia-inducible factors....

20060084797 - High affinity tgfbeta nucleic acid ligands and inhibitors: Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ2. Included in the invention are specific RNA ligands to TGFβ2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGFβ2 with its receptor....

20060084796 - Sequence-determined dna encoding methyltransferases: The present invention provides DNA molecules that constitute portions of the genome of a plant. The DNA molecules are useful for expressing a gene product, either as a promoter or as a structural gene or as an UTR or as an 3′ termination sequence and are also useful in controlling...

20060084799 - Human cdna clones comprising polynucleotides encoding polypeptides and methods of their use: The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic,...

20060084800 - Synthesis of aldonolactones, aldarolactones, and aldarodilactones using azeotropic distillation: Processes for making lactones and dilactones from aldaric acids, aldonic acids, and their corresponding salts by dehydrative cyclization and azeotropic distillation. The processes can be carried out in the presence of water because water is removed by azeotropic distillation....

20060079675 - Compositions and use of inflammation-20 (inf-20) gene: This invention relates to Inf-20, a novel apoptosis regulator, that in one embodiment is induced by TNF. The gene, designated inflammation-20 (Inf-20), encodes a polypeptide of 184 amino acids. In one embodiment Inf-20 comprises a conserved death effector domain (DED) that is capable of interacting with caspase-8, but not with...

20060079674 - Contraceptive targets: The present invention relates generally to ovary-specific genes (O1-180, O1-184 and O1-236) and the proteins they encode. Also provided are methods for detecting cell proliferative or degenerative disorders in reproductive tissues. Yet further, the invention provides methods for scrounge of compounds that interact and/or modulate the expression or activity of...

20060079672 - Kits for modulating angiogenesis: The present invention relates to kits for modulating angiogenesis. In some embodiments, a kit of the present invention comprises a container comprising a multi-unit complex wherein at least one unit of said multi-unit complex comprises a tRNA synthetase fragment or a homolog or analog thereof. In some embodiments, a kit...

20060079673 - Polynucleotides encoding trna synthetase fragments and uses thereof: The present invention relates to compositions and methods for treating conditions associated with angiogenesis. In particular the present invention relates to polynucleotides encoding a tRNA synthetase fragment, or more two or more tRNA synthetase fragments....

20060074232 - Matrimony gene and protein: The present invention is generally directed to Matrimony (Mtrm) nucleotide sequences, polypeptides expressed from the nucleotide sequences and methods employing the Mtrm nucleotide and polypeptide sequences. The Mtrm nucleotide sequences of the invention express a dosage dependent polypeptide that mediates achiasmate chromosome disjunction. In particular, reduction in the amount of...

20060074233 - Dna encoding snorf33 receptor: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences...

20060074234 - Isolated mammalian membrane protein genes; related reagents: Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided....

20060074235 - Glycolipids derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates: where R3 indicates a substituted or unsubstituted C1 to C7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R8 indicates a substituted or unsubstituted C1 to C35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted...