Organic compounds -- part of the class 532-570 series inventions 02/06

20060041109 - Neoglycorandomization and digitoxin analogs: The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or...

20060041111 - Dock 3 tumor suppressor gene: The invention relates to a newly identified tumor suppressor gene, designated DOS (for Deleted in Osteosarcoma and alternatively referred to herein as DOCK 3) which has been cloned from human and mouse cells. The DOS nucleic acid and protein molecules and their use in the diagnosing and treating disorders characterized...

20060041110 - Enzymatic template polymerization: A conductive polymer is formed enzymatically in the presence of a polynucleotide template. The method includes combining at least one redox monomer with a polynucleotide template and a redox enzyme, such as horseradish peroxidase, to form a reaction mixture. The monomer aligns along the template before or during the polymerization....

20060041112 - Novel human g-coupled protein receptor kinases and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are desclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications....

20060041113 - Phytase enzymes, nucleic acids encoding phytase enzymes and vectors and host cells incorporating same: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA...

20060041114 - Activators for oligonucleotide synthesis: wherein p is 0 or an integer from 1 to 4; X7 is O or S; R for each occurrence is a substituent, preferably each independently, a halo, a substituted or unsubstituted aliphatic group, —NR11R12, —OR13, —OC(O)R13, —C(O)OR13, or cyano; or two adjacent R groups taken together with the carbon...

20060041115 - Methods for preparing oligonucleotides having chiral phosphorothioate linkages: Methods are provided for preparing internucleotide phosphorothioate linkages that are enriched in the Sp or Rp enantiomer comprising coupling a synthon with a 2′-substituted nucleoside in the presence of coupling agent that is selected to enhance either the Rp or Spenantiomer according to its pKa....

20060041116 - Dual-functional ion exchange resins from agricultural by-products: A process for the production of dual-functional ion exchange resins from lignocellulosic agricultural material involving anionization of the lignocellulosic agricultural material with citric acid and then cationization of the lignocellulosic agricultural material with dimethyloldihydroxyethylene urea (DMDHEU) and choline chloride, or cationization of the lignocellulosic agricultural material with DMDHEU and choline...

20060041117 - Process for the preparation of cellulose derivatives containing amino groups: in which: X is selected from the group consisting of chlorine, bromine, iodine and a sulfonic acid radical R′SO3, in which R′ is an aromatic radical or an aliphatic radical; n is at least 2; and R1 and R2 independently of each other are selected from the group consisting of...

20060041118 - High- concentration liquid pullulan and method of circulating the same: The present invention has objects to provide a novel high pullulan content liquid and a method for transporting the same, and solves the objects by providing a high pullulan content liquid which has a viscosity of 2.5 mm2/s or more in terms of a pullulan concentration of 10% (w/w) when...

20060036085 - Purification of a triple helix formation with an immobilized oligonucleotide: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix....

20060036087 - 2'-deoxy-2'-fluoro modified rna: The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino and disubstituted amino groups, a process for the...

20060036088 - Natural promoters for gene expression in c1 metabolizing bacteria: Genes have been identified in the Methylomonas genome that are responsive to various metabolic and growth conditions. The identified responsiveness of these genes allows for the use of their promoters in regulated gene expression in C1 metabolizing bacteria. In particular, the hps promoter, which in its native state drives the...

20060036086 - Use of signal transduction inhibitors and combination therapies for the prevention or treatment of cancer and angiogenesis related diseases: The invention provides improved compositions (e.g., combinations of signal transduction inhibitors) and methods for the prevention, stabilization, or treatment of cancer or other angiogenesis related diseases. In particular, the present methods use combination therapies to modulate the expression or activity of multiple mRNA molecules or proteins associated with angiogenesis or...

20060036089 - 33 human secreted proteins: The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for...

20060036090 - Method for the chemical synthesis of oligonucleotides: The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof....

20060030697 - Simple process for obtaining beta-aescin from indian horse chesnut (aesculus indica): The present invention relates to development of a simplified process for purification of β-aescin from Indian horse chestnut (Aesculus indica) by aqueous alcohol extraction, solvent—solvent partition, treatment with base followed by passing the organic layer through acidic alumina in 2.0-3.0% yield of purity. minimum 90%....

20060030698 - Nucleic acid molecules and other molecules associated with plants: The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid molecules that encode proteins and fragments of proteins produced in plant cells, in particular, soybean plants. The invention also relates to proteins and fragments of proteins so encoded and antibodies capable of...

20060030699 - Versatile linker compound and ligand, and method for preparation thereof: A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a...

20060030700 - D-ribose, its monohydrate and their caramels: This invention discloses the formation of a new molecule when one mole only of D-ribose crystalline powder is mixed with one mole only of water at room temperature which new substance is entirely different from the precursor molecule, and a monohydrate of D-ribose is the likely newly discovered molecule formed...

20060025580 - Novel human estrogen receptor beta: The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-β (hERβ), which comprises 530 amino acids. The invention also provides isolated hERβ polypeptides and hERβ-reactive antibodies, including those that specifically recognize amino acids 1-45 of hERβ. The invention also encompasses methods for identifying hERβ-interactive compounds, including agonists, antagonists,...

20060025581 - Novel human gaba receptor proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications....

20060025582 - Promoter sequences for corticotropin releasing-factor receptor crf2alpha and method of identifying agents that alter the activity of the promoter sequences: The DNA sequences of human and rat CRF2α receptor promoters are disclosed. Certain functional fragments of the human CRF2α receptor promoter are also disclosed. Further disclosed are a method of identifying functional fragments of human and rat CRF2α receptor promoters and a method of identifying agents that can alter the...

20060025583 - Chemically modified polyaminosaccharide by a hydrocarbyl sultone compound: This invention discloses chemically modified polyaminosaccharides, in particular chemically modified chitosans, in the molecular structure of which a predetermined proportion of the amino functional groups is sulfonated by the hydrocarbyl sultone compound via a covalent bond. Such chemically modified polyaminosaccharides may be produced by a process of sulfonating an un-modified...

20060025584 - Crystallization of polyol compositions, crystalline polyol composition product and use thereof: The present invention relates to a microcrystallized polyol comprising at least two polyols, wherein said polyols are selected from the group consisting of maltitol, xylitol and lactitol and wherein said composition contains at least 25% by weight of each of at least two of said polyols microcrystallized together into a...

20060025585 - Manufacturing process for porous material: A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a gel, and (c) optionally cross-linking the polysaccharide, with the...