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  Oleaginous pharmaceutical and cosmetic foamUSPTO Application #: 20080050317Title: Oleaginous pharmaceutical and cosmetic foam Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition. (end of abstract) Agent: Wilmerhale/boston - Boston, MA, US Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov USPTO Applicaton #: 20080050317 - Class: 424045000 (USPTO) Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Effervescent Or Pressurized Fluid Containing, Organic Pressurized Fluid The Patent Description & Claims data below is from USPTO Patent Application 20080050317. Brief Patent Description - Full Patent Description - Patent Application Claims
RELATED APPLICATIONS [0001] This application is a continuation of and claims priority under 35 U.S.C. .sctn.120 to U.S. patent application Ser. No. 10/835,505, filed on Apr. 28, 2004, entitled "Oleaginous Pharmaceutical and Cosmetic Foam," which claims priority under 35 U.S.C. .sctn. 119(e) to co-pending U.S. Provisional Patent Application No. 60/530,015, filed Dec. 16, 2003, entitled "Oleaginous Pharmaceutical and Cosmetic Foam," and U.S. Provisional Patent Application No. 60/492,385, filed Aug. 4, 2003, and entitled "Cosmetic and Pharmaceutical Foam," all of which are incorporated herein in their entirety by reference. FIELD OF THE INVENTION [0002] The invention relates to oleaginous foam compositions including cosmetic or therapeutic active agents, and methods of topical treatment using the compositions. BACKGROUND OF THE INVENTION [0003] Certain foam products for topical application of therapeutical agents and cosmetics have been prepared as oil-in-water emulsions. Foams and, in particular, foam compositions having a high oil content are complicated systems that do not form under all circumstances. Slight shifts in foam composition, such as the addition of an active ingredient, may destabilize the foam. It is known in the art that hydrophobic solvents are difficult to formulate into a foam-producing product. Addition of conventional hydrophobic solvents interferes with the foam forming ability of the surfactant, and thus, in the few foam products containing high-oil concentrations that have been reported, high surfactant concentrations are used, which may cause undesirable irritancy on one hand, and costly raw material usage on the other hand are used. [0004] Oleaginous formulations for the preparation of cosmetic and therapeutic compositions are known in the art. [0005] U.S. Pat. No. 6,620,773 relates to a foaming oil composition, which includes a surfactant mixture and an oil component, the surfactant mixture containing an anionic or zwitterionic surfactant, a nonionic surfactant and at least one ethoxylated alkyl phosphate ester component. The surfactant mixture ranges from about 15% to about 50% of the total composition, and that of the oil component ranges from about 50% to about 85%. [0006] U.S. Pat. Nos. 5,700,396 and 5,589,515 disclose a cosmetic emulsion composition containing 0.1 to 99 wt % oily component (balance aqueous component). The oily component includes 85% or more weight % of cis A9-octadecanoic acid or derivatives thereof, which serves as a surfactant in the formulation. [0007] U.S. Pat. No. 6,524,594 describes a gelled oil composition containing an emulsifier, a gelling agent, an oil, and a surfactant which, when applied to the skin in the presence of water, produces a significant amount of foam. The surfactant is used in an amount from about 10% to about 20%, and more preferably, from about 15% to about 20%. [0008] U.S. Pat. No. 6,121,210 discloses foamable, silicone oil compositions and methods of lubricating surfaces with such compositions. The compositions are oil-in-water emulsions comprising silicone oil-in-water emulsion, a liquid propellant and a foam builder comprising a solid, non-ionic lipophilic surfactant having an HLB value of about 3 to about 8. Foam stabilizers including long claim fatty alcohols are included. A propellant is included to create a foamable composition. [0009] In general, the foamable compositions of the art are based on oil-in-water emulsions. Furthermore, they often include a high content level of surfactants and foaming agents required to form acceptable foams which are stable and possess low specific gravity. Such surfactants, and particularly ionic surfactants, such as anionic surfactants (e.g. sodium lauryl sulfate (SDS)), may have adverse affects on certain patients, including concentration-dependent skin irritation. [0010] There remains an unmet need for improved, stable and non-irritating oleaginous foam formulations, intended for dermal and mucosal delivery of pharmaceutical and cosmetic, with unique therapeutic and cosmetic properties. SUMMARY OF THE INVENTION [0011] The present invention provides stable, oleaginous foam-forming compositions including at least one active agent for dermal and mucosal delivery. The composition is dispensed as a foam providing a stable product that is pleasant and easy to spread, resulting in high patient compliance. The "oleaginous" composition has the organoleptic character of an oily substance, i.e., an oily feeling, when topically administered to the skin or mucosal tissue. [0012] According to one aspect or the present invention, the composition includes: [0013] a. at least one solvent selected from a hydrophobic solvent, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition; [0014] b. a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; [0015] c. at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; [0016] d. at least one active agent in a therapeutically effective concentration; and [0017] e. at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition. [0018] Water and optional ingredients are added to complete the total weight to 100%, although the composition may be essentially free of lower alkyl alcohols. In one or more embodiments, the oleaginous composition of the present invention contains less than about 5% of a lower alcohol having up to 5 carbon atoms in its carbon chain skeleton. [0019] In one or more embodiments, the oleaginous composition includes water at a concentration less than about 30%, preferably less than about 20%, more preferably less than about 10% by weight. [0020] In one or more embodiments, the oleaginous composition of the present invention further includes a foam adjuvant. Continue reading... Full patent description for Oleaginous pharmaceutical and cosmetic foam Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Oleaginous pharmaceutical and cosmetic foam patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. 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