Novel polypeptides involved in immune response

Title: Novel polypeptides involved in immune response

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20080152651, Novel polypeptides involved in immune response.

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31. (canceled)

32. An antibody or fragment thereof which binds to a B7RP1 polypeptide as set forth in FIG. 12A (SEQ ID NO:17) or a mature form thereof.

33. An antibody or fragment thereof which binds to a B7RP1 polypeptide as set forth in FIG. 3A (SEQ ID NO:12) or a mature form thereof.

34. An antibody or fragment thereof which specifically binds to a mature form of a B7RP1 polypeptide as set forth in FIG. 3A (SEQ ID NO:12) or FIG. 12A (SEQ ID NO:17).

35. The antibody or fragment of claim 34 which binds to a membrane-associated form of a B7RP1 polypeptide as set forth in FIG. 3A (SEQ ID NO:12) or FIG. 12A (SEQ ID NO:17).

36. The antibody or fragment of claim 34 which binds to a soluble form of a B7RP1 polypeptide as set forth in FIG. 3A (SEQ ID NO:12) or FIG. 12A (SEQ ID NO:17).

37. The antibody or fragment of claim 34 which binds to an extracellular domain, or fragment thereof, of a B7RP1 polypeptide as set forth in FIG. 3A (SEQ ID NO:12) or FIG. 12A (SEQ ID NO:17).

38. The antibody or fragment of claim 32 which partially or completely blocks the binding of B7RP1 to CRP1.

39. The antibody or fragment of claim 32 which increases B7RP-1 mediated T cell costimulatory activity.

40. The antibody or fragment of claim 32 which decreases B7RP-1 mediated T cell costimulatory activity.

41. The antibody or fragment of claim 32 which partially or completely inhibits B7RP-1 mediated T cell costimulatory activity.

42. An antibody or fragment thereof which binds to a polypeptide, or a mature form thereof, encoded by the nucleotide sequence as set forth in FIG. 3A (SEQ ID NO: 11) or FIG. 12A (SEQ ID NO: 16).

43. An antibody or fragment which binds to a soluble form of B7RP1, wherein the soluble form of B7RP1, or a mature form thereof, is encoded by the nucleic acid as set forth in FIG. 12A (SEQ ID NO:16).

44. The antibody of claims 32 or 43 which is a monoclonal antibody.

45. The antibody of claims 32 or 43 which is selected from a chimeric antibody, a single chain antibody, a bispecific antibody, a CDR-grafted antibody or a humanized antibody.

46. The antibody of claims 32 or 43 which is a human antibody.

47. A pharmaceutical composition comprising the antibody of claims 32 or 43 and a carrier, diluent, and/or excipient.

Brief Patent Description - Full Patent Description - Patent Claims

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