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Novel nucleic acid molecules and polypeptides encoding baboon tafi

Abstract: The present invention relates to the isolation and identification of novel baboon nucleic acid molecules and proteins and polypeptides encoded by such nucleic acid molecules, or degenerate variants thereof, which proteins and polypeptides comprise novel baboon thrombin-activatable fibrinolysis inhibitors or “TAFI” enzyme molecules. Because the novel baboon TAFI proteins and polypeptides of the invention inhibit the breakdown of blood clots, they may be therapeutically useful for the treatment of blood disorders wherein clotting needs to be regulated or promoted, such as hemophilia or von Willebrand's disease or in other situations, such as trauma, wherein blood clotting or coagulation needs to be regulated or promoted. The sequences of the invention are also useful in screening methods for the identification of compounds that modulate the expression of the baboon TAFI nucleic acids and/or the activity of the baboon TAFI proteins and polypeptides of the invention. Such agonist or antagonist compounds may be useful in the treatment of various blood clotting disorders and conditions requiring hemostatic control such as hemophilia or various thrombotic diseases such as deep venous thrombosis, coronary artery disease, stroke associated with atrial fibrillation and recurrent thrombosis following stroke or myocardial infarction. ...

USPTO Applicaton #: #20060257921 - Class: 435006000 (USPTO)

Related Patent Categories: Chemistry: Molecular Biology And Microbiology, Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip, Involving Nucleic Acid
The Patent Description & Claims data below is from USPTO Patent Application 20060257921, Novel nucleic acid molecules and polypeptides encoding baboon tafi.

Afi Artery Atria Atrial Atrial Fib Atrial Fibrillation Blood Clot Blood Clots Breakdown Coagulation Coronary Coronary Artery Coronary Artery Disease Deep Venous Thrombosis Fibril Fibrillation Fibrin Hemophilia Hemostatic Ibrin Infarct Infarction Myocardial Infarction RCT Recurrent Romb Thrombi Thrombin Thrombosis Trauma Venous Thrombosis

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