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Novel lactam derivativesRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon Atoms, Asymmetrical (e.g., 1,2,4-triazine, Etc.)Novel lactam derivatives description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060287321, Novel lactam derivatives. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of 10/492,062 filed on Apr. 8, 2004 which was filed pursuant to 35 U.S.C. .sctn. 371 as a United States National Phase Application of International Application No. PCT/US02/32740 filed Oct. 15, 2002, which claims priority from GB 0124627.1 filed Oct. 15, 2001. FIELD OF THE INVENTION [0002] This invention relates to novel lactam derivatives which are antagonists at the human 11CBy receptors, to processes for their preparation, to pharmaceutical compositions containing them and to their uses in therapy. [0003] WO01/21577 (Takeda) relates to a compound of the formula wherein Ar.sup.1 is a cyclic group which may have substituents, X is a spacer having a main chain of 1 to 6 atoms, Y is a bond or a spacer having a main chain of 1 to 6 atoms, Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R.sup.1 and R.sup.2 are independently hydrogen or a hydrocarbon group which may have substituents; R.sup.1 and R.sup.2 together with the adjacent nitrogen atom may form a nitrogen containing hetero ring which may have substituents; R.sup.2 may form a spiro ring together with Ar; or R.sup.2 together with the adjacent nitrogen atom may form a nitrogen containing hetero ring which may have substituents; or a salt thereof, and which compounds are antagonists of a melanin concentrating hormone. Such compounds are suggested as being useful for preventing or treating obesity. [0004] We have now found a novel group of compounds that exhibit a useful profile of activity as antagonists of the human 11CBy receptor (also referred to as MCHR1) disclosed in Nature 400, 261-265 (1999). SUMMARY OF THE INVENTION [0005] The invention thus provides compounds of formula (I) a salt or solvate thereof, wherein [0006] M is a group selected from the group consisting of O, S, C.dbd.O, NH and CH.sub.2; [0007] L is a 2 or 3 membered alkylene chain; [0008] wherein together M-L may be optionally substituted by at least one moiety selected from the group consisting of methyl, ethyl, hydroxy and C.sub.1-3 alkoxy; [0009] R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, C.sub.1-6 straight or branched alkyl which may be optionally substituted by phenyl, and C.sub.3-6 cycloalkyl optionally substituted by one or more C.sub.1-6 alkyl groups; [0010] each R.sup.6 is the same or different and is independently selected from the group consisting of hydroxy, C.sub.1-2alkyl, C.sub.1-3alkoxy, halo, C.sub.2-3alkenyl, benzyl, and --C(R.sup.a)NOR.sup.b, wherein R.sup.a and R.sup.b are each independently selected from the group consisting of hydrogen, methyl, methoxymethyl, methoxymethoxyl, and methoxyethoxyl; and n is 1, 2, 3, or 4; [0011] QY is a bicyclic fused heterocyclic ring wherein Q and Y are each one ring of said bicyclic fused heterocyclic group, wherein said Y ring contains from 1 to 3 nitrogens and is bound to the phenyl ring of formula (I) via a nitrogen atom, and said Q ring is a 5 or 6 membered aryl or heterocyclic ring having a group ZR.sup.3; Z is bound to the Q ring; [0012] Z is selected from the group consisting of a direct bond, NH, NCH.sub.3, O, S or CH.sub.2; and [0013] R.sup.3 is a group selected from the group consisting of aryl, alk-2-en-1-yl, cycloalkyl and cycloalk-2-en-1-yl and wherein said aryl, alk-2-en-1-yl, cycloalkyl, and cycloalk-2-en-1-yl are optionally substituted from 1 to 3 times with a subsittuent selected from the group consisting of C.sub.1-3 alkyl, halo, amino, alkylamino, dialkylamino, hydroxy, C.sub.1-3 alkoxy, cyano, trifluoromethyl, and methylthio groups. [0014] The invention also includes embodiments to (i) a pharmaceutical formulation comprising a compound of formula (I), (ii) the use of a compound of formula (I) or a pharmaceutical formulation comprising the formula (I) in therapy, and (iii) processes for the preparation of a compound of formula (I). DETAILED DESCRIPTION OF THE INVENTION [0015] In the present invention, unless otherwise stated, references to salts, include both physiologically acceptable salts and non-physiologically acceptable salts of compounds of formula (I). The compounds of formula (I) and salts thereof may form solvates (e.g. hydrates) and the invention includes all such solvates. [0016] As used herein, "a compound of the invention" or a compound of formula (I) means a compound of formula (I) or a pharmaceutically acceptable salt, or solvate thereof. [0017] As used herein, the term "optionally" means that the subsequently described event(s) may or may not occur, and includes both event(s) that occur and events that do not occur. [0018] The term "alkyl" as a group or part of a group (e.g., alkoxy, alkylamino, etc.) refers to a straight or branched alkyl group. Said alkyl contains from 1 to 6 carbon atoms unless otherwise specified. Examples of such C.sub.1-6 alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, neopentyl or hexyl. [0019] The term "alk-2-en-1-yl" refers to a straight or branched C.sub.3-6 alk-2-en-1-yl group. Continue reading about Novel lactam derivatives... Full patent description for Novel lactam derivatives Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Novel lactam derivatives patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. 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