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Novel heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as beta-lactamase inhibitors and antibacterialsRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Phosphorus Containing Other Than Solely As Part Of An Inorganic Ion In An Addition Salt Doai, Nitrogen Containing Hetero Ring, Polycylo Ring System Having A Ring Nitrogen In The SystemNovel heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as beta-lactamase inhibitors and antibacterials description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070191312, Novel heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as beta-lactamase inhibitors and antibacterials. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of U.S. patent application Ser. No. 10/655,364, filed on Sep. 4, 2003, which claims the benefit of priority from French Patent Application 02 10957, filed Sep. 5, 2002. The disclosures of the above applications are incorporated herein by reference. SUMMARY OF THE INVENTION [0002] The present disclosure relates to novel heterocyclic compounds, to their preparation and their use as medicaments, in particular as .beta.-lactamase inhibitors and antibacterials. BACKGROUND OF THE INVENTION [0003] The statements in this section merely provide background information related to the present disclosure and may not constitute prior art. [0004] The preparation of a bicyclic derivative of empirical formula C.sub.10H.sub.18N.sub.2O is disclosed in J. Org. Chem., Vol. 37, No. 5, 1972, pages 697 to 699. [0005] The preparation of bicyclic derivatives of empirical formulae C.sub.6H.sub.9NO.sub.2 and C.sub.7H.sub.11NO.sub.2 is disclosed in J. Org. Chem., Vol. 45, No. 26, 1980, pages 5325-5326. [0006] The preparation of bicyclic derivatives of empirical formulae C.sub.10H.sub.18N.sub.2O and C.sub.7H.sub.12N.sub.2O is disclosed in Chemical Reviews, 1983, Vol. 83, No. 5, pages 549 to 555. [0007] The preparation of a compound of empirical formula C.sub.12H.sub.12N.sub.2O is disclosed in Angew. Chem. Int. Ed., 2000, 39, No. 3, pages 625 to 628. [0008] No specific therapeutic use of these compounds was disclosed in these documents. [0009] French patent application No. 2 812 635 discloses that variously substituted heterocyclic compounds, in particular of the 7-oxo-1-aza- or 1,6-diazabicyclo[3.2.1]octane type, exhibit antibacterial properties. DETAILED DESCRIPTION [0010] The following description is merely exemplary in nature and is not intended to limit the present disclosure, application, or uses. [0011] The present invention relates to compounds of formula (I): [0012] in which: [0013] n is 1 or 2; [0014] R.sub.1 is selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms and (CH.sub.2).sub.n, R.sup.o.sub.1 in which n' is 0 or 1 and R.sup.o.sub.1 is selected from the group consisting of aryl having up to 12 carbon atoms; heteroaryl having up to 15 carbon atoms and at least one heteroatom selected from N, S, and O; COR'; CONR'R''; CSNR'R''; COCOOR'; SO.sub.2NR'R''; SO.sub.2R'; CO.sub.2R' and CN; [0015] R' is selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms, alkenyl having up to 8 carbon atoms, aralkyl having up to 12 carbon atoms and aryl having up to 12 carbon atoms; [0016] R'' is selected from the group consisting of hydrogen; alkyl having up to 8 carbon atoms; aryl having up to 12 carbon atoms; aralkyl having up to 12 carbon atoms; SO.sub.2--R' and COR'; in each case R' being independently selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms, alkenyl having up to 8 carbon atoms, aralkyl having up to 12 carbon atoms and aryl having up to 12 carbon atoms; [0017] R.sub.2 is selected from the group consisting of hydrogen, halo, alkyl, OH, Oalkyl, NO.sub.2, NH.sub.2, NHalkyl, N(alkyl).sub.2, NHCOalkyl, NHSO.sub.2alkyl, CONHalkyl, SO.sub.2NHalkyl, COOH, COOalkyl, CN, OSO.sub.2alkyl, NHCONHalkyl and COalkyl; said alkyl having up to 8 carbon atoms; [0018] X is a divalent group --C(O)--N(OR.sub.3)-- connected to the ring nitrogen atom via its carbonyl carbon atom and to the ring carbon atom via its nitrogen atom, in which R.sub.3 is selected from the group consisting of hydrogen and the R, Y, Y.sub.1, Y.sub.2 and Y.sub.3 moieties defined below, [0019] R is selected from the group consisting of alkyl having up to 6 carbon atoms, optionally substituted by pyridyl or carbamoyl; alkenyl having up to 8 carbon atoms; aryl having up to 12 carbon atoms; and aralkyl having up to 12 carbon atoms; each said aryl group optionally being substituted by an --OH, --NH.sub.2, --NO.sub.2, alkyl having up to 8 carbon atoms, an alkoxy having up to 8 carbon atoms or by one or more halogens; [0020] Y is selected from the group consisting of COR, COOH, COOR, CONHR, CONHOH, CONHSO.sub.2R, CH.sub.2COOH, CH.sub.2COOR, CH.sub.2CONHOH, CH.sub.2CONHCN, CH.sub.2tetrazole, CH.sub.2 (protected tetrazole), CH.sub.2SO.sub.3H, CH.sub.2SO.sub.2R, CH.sub.2PO(OR).sub.2, CH.sub.2PO(OR)(OH), CH.sub.2PO(R)(OH) and CH.sub.2PO(OH).sub.2, wherein R is as defined hereinabove; Continue reading about Novel heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as beta-lactamase inhibitors and antibacterials... 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