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New mandelic acid derivatives and their use as thrombin inhibitors pdficon_sm

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Abstract: There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants. ...

Agent: Morgan Lewis & Bockius LLP - Washington, DC, US
Inventors: Tord Inghardt, Anders Johansson, Arne Svensson
USPTO Applicaton #: #20070218136 - Class: 424484000 (USPTO)

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Related Terms: Anticoagulant   Anticoagulants   Competitive Inhibitor   Mandel   Thrombi   Thrombin   Thrombosis   Trypsin    Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Preparations Characterized By Special Physical Form, Matrices
The Patent Description & Claims data below is from USPTO Patent Application 20070218136, New mandelic acid derivatives and their use as thrombin inhibitors.

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Anticoagulant   Anticoagulants   Competitive Inhibitor   Mandel   Thrombi   Thrombin   Thrombosis   Trypsin   


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