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New amidino derivatives and their use as thrombin inhibitors

Abstract: wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants. There is provided compounds of formula I ...

Agent: Nixon & Vanderhye, PC - Arlington, VA, US
Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nystrom
USPTO Applicaton #: #20070249578 - Class: 514210180 (USPTO)

Related Terms: Anticoagulant Anticoagulants Competitive Inhibitor Protease Thrombi Thrombin Thrombosis Trypsin Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Four-membered And Includes At Least One Ring Nitrogen, Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Four-membered Hetero Ring, Additional Hetero Ring Attached Directly Or Indirectly To The Four-membered Hetero Ring By Nonionic Bonding
The Patent Description & Claims data below is from USPTO Patent Application 20070249578, New amidino derivatives and their use as thrombin inhibitors.

Anticoagulant Anticoagulants Competitive Inhibitor Protease Rx RX Thrombi Thrombin Thrombosis Trypsin

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