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10/25/07 | 54 views | #20070248958 | Prev - Next | USPTO Class 435 | About this Page  435 rss/xml feed  monitor keywords

Microfluidic devices

USPTO Application #: 20070248958
Title: Microfluidic devices
Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense. (end of abstract)
Agent: Wilson Sonsini Goodrich & Rosati - Palo Alto, CA, US
Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, David Rank
USPTO Applicaton #: 20070248958 - Class: 435006000 (USPTO)
Related Patent Categories: Chemistry: Molecular Biology And Microbiology, Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip, Involving Nucleic Acid
The Patent Description & Claims data below is from USPTO Patent Application 20070248958.
Brief Patent Description - Full Patent Description - Patent Application Claims  monitor keywords

B. STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0001] This application claims the benefit under 35 U.S.C. .sctn.119(e) of U.S. provisional patent application Ser. No. 60/609,970, filed Sep. 15, 2004, the disclosure of which is incorporated herein by reference in its entirety.

C. BACKGROUND

[0003] A wide variety of microfluidic devices of disparate, and often incompatible, design have been developed over the past 10-20 years, often with the goal of reducing sample volume requirements in bioanalytical methods. In the absence of standards controlling external dimensional form factors, the nature of the upstream and downstream external interface, and the length, cross-sectional geometry, and diameter of the internal microfluidic pathways, such microfluidic devices often prove incompatible with one another and with existing upstream purification and downstream analytical devices.

[0004] Despite advances in microfabrication, making possible analysis at microliter, even nanoliter or picoliter, scale, many biological and environmental samples are first acquired in volumes far greater than, and incompatible with, the scale of existing microfluidic analytical devices.

[0005] There is thus a need in the art for modular microfluidic components that can be used as components of integrated fluidic systems, and that can interface microfluidic components having different external dimensional form factors, external interfaces, and/or internal fluidic geometries, into effective fluidic communication, and that can interface preparative modules, or methods, that operate at larger scale with microfluidic preparative and/or analytical components.

D. SUMMARY

[0006] The present invention solves these and other needs in the art.

E. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] The skilled artisan will understand that the drawings, described below, are for illustration purposes only and are not intended to limit the scope of the present disclosure in any way.

[0008] FIG. 1 illustrates an embodiment of a sample capture and purification module (SCPM) and bioprocessor module (BPM) workflow.

[0009] FIG. 2 illustrates an embodiment of a toxin assay workflow.

[0010] FIG. 3 illustrates an embodiment of a sample capture and purification module (SCPM) integrated with a bioprocessor module (BPM).

[0011] FIG. 4 illustrates an embodiment of an off-chip flow-through cartridge.

[0012] FIG. 5 illustrates an embodiment of a traveling wave flowthrough bead beater.

[0013] FIG. 6 illustrates an embodiment of flowthrough sonication in which a probe is inserted directly into a collector effluent.

[0014] FIG. 7 illustrates an embodiment of a nucleic acid purification module.

[0015] FIG. 8 illustrates an embodiment of a nanobioprocessor modular system that can be used for biodefense applications comprising an air sampler, sample concentration module, and a microfluidic sample amplification and analysis module.

[0016] FIG. 9 illustrates an embodiment of a MOV.TM. valve.

[0017] FIG. 10 illustrates an embodiment of a microfabricated pump.

[0018] FIG. 11 illustrates an embodiment of a microfabricated router.

[0019] FIG. 12 illustrates an embodiment in cross-section of three dimension connection service channel supplying sample cleanup matrix.

[0020] FIG. 13 illustrates an embodiment of a fluidic circuit for adding one or more reactants to a reaction chamber.

[0021] FIG. 14 illustrates an embodiment of a cycle sequencing module (CSM) repeat unit.

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Full patent description for Microfluidic devices

Brief Patent Description - Full Patent Description - Patent Application Claims
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