| Methylphenidate derivatives and uses of them -> Monitor Keywords |
|
|
 
Methylphenidate derivatives and uses of themRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms, Piperidines, Additional Ring ContainingMethylphenidate derivatives and uses of them description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060189655, Methylphenidate derivatives and uses of them. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims benefit of provisional applications Nos. 60/645,778, filed Jan. 20, 2005, and 60/663,006, filed Mar. 18, 2005, the complete disclosures of which are incorporated herein by reference. FIELD OF THE INVENTION [0002] The invention relates to uses of methylphenidate derivatives. The uses include inhibiting angiogenesis and treating angiogenic diseases and conditions. BACKGROUND [0003] Methylphenidate is the treatment of choice for children and adults diagnosed with attention deficit/hyperactivity disorder (ADHD), including its inattentive subtype (formerly known as attention deficit disorder or ADD). Certain derivatives of methylphenidate have also been proposed for the treatment of ADD (see U.S. Pat. No. 6,025,502) and for the treatment of other neurological disorders and conditions (see U.S. Pat. Nos. 5,859,249, 6,025,502 and 6,486,177 and PCT application WO 99/36403). [0004] Methylphenidate is a mild central nervous stimulant and is also taught for treating apathy, fatigue, cognitive decline, and depression in cancer patients, AIDS patients and other seriously ill patients. See U.S. Pat. Nos. 5,908,850, 6,127,385, 6,395,752 and 6,486,177, Challman and Lipsky, Mayo Clin. Proc., 75:711-721 (2000) and Leonard et al., Hum. Psychopharmacol. Clin. Exp., 19:151-180 (2004). [0005] It has been reported that methylphenidate is not carcinogenic, and that there is a less than expected rate of cancer, in rats and humans taking methylphenidate. See Dunnick and Hailey, Toxicology, 103:77-84 (1995), National Toxicology Program, Natl. Toxicol. Program Tech. Rep. Ser., 439:1-299 (1995), Dunnick et al., Cancer Lett., 102:77-83 (1996) and Teo et al., Mutat. Res., 537:67-79 (2003). However, there is some evidence that methylphenidate is carcinogenic in mice. Dunnick and Hailey, Toxicology, 103:77-84 (1995) and National Toxicology Program, Natl. Toxicol. Program Tech. Rep. Ser., 439:1-299 (1995). Further, some types of tumors have been reported to be decreased, while other types of tumors have been reported to be increased. See Dunnick and Hailey, Toxicology, 103:77-84 (1995), National Toxicology Program, Natl. Toxicol. Program Tech. Rep. Ser., 439:1-299 (1995) and Dunnick et al., Cancer Lett., 102:77-83 (1996). SUMMARY OF THE INVENTION [0006] The invention provides methods of using a compound of formula I wherein n is an integer from 1 to 5, and each R.sup.1 is independently aryl, heteroaryl, alkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, sulfo or sulfhydryl. Each alkyl can optionally be substituted with hydroxyl, amino or sulfhydryl. R.sup.2 is hydrogen or lower alkyl. [0007] In a first embodiment, the invention provides a method of inhibiting angiogenesis in an animal. The method comprises administering an effective amount of a compound of formula I, or a pharmaceutically-acceptable salt or a prodrug thereof, to the animal. [0008] In a second embodiment, the invention provides a method of treating an angiogenic disease or condition in an animal. The method comprises administering a therapeutically effective amount of a compound of formula I, or a pharmaceutically-acceptable salt or a prodrug thereof, to the animal. [0009] In a third embodiment, the invention provides a method of treating a proliferative disorder in an animal. The method comprises administering a therapeutically effective amount of a compound of formula I, or a pharmaceutically-acceptable salt or a prodrug thereof, to the animal. [0010] The invention also provides a compound of formula IA: where [0011] n is an integer from 1 to 5; [0012] each R.sup.1 is independently a moiety of the formula --C(O)--R.sup.8, --OR.sup.7 or --C(O)--O--R.sup.3; [0013] R.sup.2 is hydrogen or lower alkyl; [0014] R.sup.3 is hydrogen, alkyl, cycloalkyl or aryl; [0015] R.sup.7 is aryl; and [0016] R.sup.8 is cycloalkyl or aryl. [0017] The invention further provides a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula IA: or a salt or prodrug thereof, where [0018] n is an integer from 1 to 5; [0019] each R.sup.1 is independently a moiety of the formula --C(O)--R.sup.8, --OR.sup.7 or --C(O)--O--R.sup.3; [0020] R.sup.2 is hydrogen or lower alkyl; Continue reading about Methylphenidate derivatives and uses of them... Full patent description for Methylphenidate derivatives and uses of them Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Methylphenidate derivatives and uses of them patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Methylphenidate derivatives and uses of them or other areas of interest. ### Previous Patent Application: Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones Next Patent Application: Novel compounds and compositions as cathepsin inhibitors Industry Class: Drug, bio-affecting and body treating compositions ### FreshPatents.com Support Thank you for viewing the Methylphenidate derivatives and uses of them patent info. IP-related news and info Results in 0.1896 seconds Other interesting Feshpatents.com categories: Medical: Surgery , Surgery(2) , Surgery(3) , Drug , Drug(2) , Prosthesis , Dentistry 174 |
 * Protect your Inventions * US Patent Office filing 
PATENT INFO |
|
