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Methods for shp1 mediated neuroprotection   

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Abstract: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells. ...

Agent: Philip S. Johnson Johnson & Johnson - New Brunswick, NJ, US
Inventors: Michael Renzi, Navneeth Thirumalai, Linda Jolliffe, Francis X. Farrell
USPTO Applicaton #: #20070065885 - Class: 435007200 (USPTO) - 03/22/07 - Class 435 

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Related Patent Categories: Chemistry: Molecular Biology And Microbiology, Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip, Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay, Involving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial Lysate
The Patent Description & Claims data below is from USPTO Patent Application 20070065885, Methods for shp1 mediated neuroprotection.

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