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Methods for measuring platelet reactivity of patients that have received drug eluting stents

Abstract: A method is providing for measuring platelet reactivity of a PCI patient that has a (DES). A blood sample is obtained from the patient. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the mixture. The absence of agglutination indicates that the patient has reduced ability to form platelet thrombi. ...

Agent: Heller Ehrman LLP - Menlo Park, CA, US
Inventors: Barry S. Coller, Dennis Durbin
USPTO Applicaton #: #20070243632 - Class: 436503000 (USPTO)

Related Terms: Agglutination Anticoagulant Blood Sample Coagulate Incubate Platelet Platelet Aggregation Signal Transduction Signal Transduction Pathway Thrombi Transduction Related Patent Categories: Chemistry: Analytical And Immunological Testing, Biospecific Ligand Binding Assay, Utilizing Isolate Of Tissue Or Organ As Binding Agent
The Patent Description & Claims data below is from USPTO Patent Application 20070243632, Methods for measuring platelet reactivity of patients that have received drug eluting stents.

Agglutination Anticoagulant Blood Sample Coagulate Incubate Pci Platelet Platelet Aggregation Signal Transduction Signal Transduction Pathway Thrombi Transduction

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