| Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same -> Monitor Keywords |
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Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the sameRelated Patent Categories: Surgery, Means For Introducing Or Removing Material From Body For Therapeutic Purposes (e.g., Medicating, Irrigating, Aspirating, Etc.), Treating Material Introduced Into Or Removed From Body Orifice, Or Inserted Or Removed Subcutaneously Other Than By Diffusing Through Skin, Method, Therapeutic Material Introduced Or Removed Through A Piercing Conduit (e.g., Trocar) Inserted Into Body, Therapeutic Material Introduced Into Or Removed From VasculatureMethods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070173784, Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of U.S. patent application Ser. No. 09/774,469, filed Jan. 30, 2001 which is a continuation-in-part of application Ser. No. 09/528,576 filed Mar. 20, 2000, the disclosure of which is herein incorporated by reference. INTRODUCTION [0002] 1. Technical Field [0003] The field of this invention is vascular disease, particularly vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions. [0004] 2. Background of the Invention [0005] Vascular occlusions, which may be partial or total occlusions, play a prominent role in many types of vascular disease. Occlusions found in vascular disease may vary greatly in content, and are typically complex structures of two or more different types of components. Components found in vascular occlusions include: lipids; lipoproteins; proteins; including fibrinogen, collagen, elastin and the like; proteoglycans, such as chondroitin sulfate, heparin sulfate, dermatans, etc.; cells, including smooth muscle cells, epithelial cells, macrophages and lymphocytes; and minerals, e.g. calcium phosphates such as dahllite. An occlusion categorization system has been developed for use in characterizing vascular occlusions, where type IV, type V and type VI lesions, as defined in Stary et al, Arterioscler. Thromb. Vasc. Biol. (1995)15:1512-1531, are particularly relevant in vascular disease. [0006] A variety of different protocols have been developed for use in treating vascular diseases characterized by the presence of partial or total occlusions. Such treatment methodologies generally involve mechanical removal or reduction of the size of the occlusion, and include: bypass surgery, balloon angioplasty, mechanical debridement, atherectomy, and the like. [0007] Despite the plethora of different treatment strategies that have been developed for the treatment of vascular diseases associated with vascular occlusions, there are disadvantages associated with each technique, such as tissue damage, invasiveness, etc. For example, restenosis is a common complication that results in arteries in which occlusions have been mechanically removed. [0008] As such, there is continued interest in the development of endovascular methods of treating vascular occlusions. Of particular interest would be the development of methods and devices suitable for use in the treatment of vascular occlusions which do not suffer from the disadvantages of currently employed devices and methods. Relevant Literature [0009] U.S. Patents of interest include: U.S. Pat. Nos. 4,445,892; 4,573,966; 4,610,662; 4,636,195; 4,655,746; 4,690,672; 4,824,436; 4,911,163; 4,976,733; 5,059,178; 5,090,960; 5,167,628; 5,195,955; 5,222,941; 5,370,609; 5,380,284; 5,443,446; 5,462,529; 5,496,267; 5,785,675; 5,833,650 and 5,951,458. Multi-lumen catheter devices are described in U.S. Pat. Nos. 4,329,994; 4,838,881; 5,149,330; 5,167,623; 5,207,648; 5,542,937; and 6,013,068. SUMMARY OF THE INVENTION [0010] Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions. BRIEF DESCRIPTION OF THE FIGURES [0011] FIGS. 1A & 1B provide views of a totally occluded and partially occluded vascular site, respectively. [0012] FIG. 2A provides a representation of an aspiration catheter according to an embodiment of the subject invention while FIG. 2B provides a representation of a total occlusion catheter insert for use in the aspiration catheter of FIG. 2A. [0013] FIG. 3 provides a representation of a partial occlusion catheter insert for use in the aspiration catheter of FIG. 2A. [0014] FIG. 4 provides a depiction of the use of the partial occlusion catheter system according to the subject invention. [0015] FIG. 5 provides a representation of a system according to the subject invention, which system includes a catheter device, manifold, fluid reservoirs, etc. [0016] FIGS. 6 to 8 provides a representation of the various stages of the use of the total occlusion system of the subject invention. [0017] FIGS. 9 and 10 provide views of alternative embodiments of the subject methods in which external energy is applied to the occlusion, e.g. by movement of a guidewire as shown in FIG. 9. DESCRIPTION OF THE SPECIFIC EMBODIMENTS [0018] Methods for enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions. Continue reading about Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same... Full patent description for Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. 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