| Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis -> Monitor Keywords |
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Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesisRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai, Cyclopeptides, 2 Peptide Repeating Units In Known Peptide ChainMethods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060223761, Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis. Brief Patent Description - Full Patent Description - Patent Application Claims CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of the following U.S. Provisional Applications: [0002] 1. U.S. Provisional Application No. 60/______ which was converted pursuant to 37 C.F.R. .sctn.1.53(b)(2)(ii) from U.S. patent application Ser. No. 08/755,442, filed Nov. 22, 1996; [0003] 2. U.S. Provisional Application No. 60/______ which was converted pursuant to 37 C.F.R. .sctn.1.53(b)(2)(ii) from U.S. patent application Ser. No. 08/808,528, filed Feb. 28, 1997; [0004] 3. U.S. Provisional Application No. 60/______ which was converted pursuant to 37 C.F.R. .sctn.1.53(b)(2)(ii) from U.S. patent application Ser. No. 08/807,528, filed Feb. 28, 1997; and [0005] 4. U.S. Provisional Application No. 60/______ which was converted pursuant to 37 C.F.R. .sctn.1.53(b)(2)(ii) from U.S. patent application Ser. No. 08/807,427, filed Feb. 28, 1997. [0006] Each of these applications are incorporated herein by reference in their entirety. BACKGROUND OF THE INVENTION Field of the Invention [0007] This invention relates to methods which inhibit cellular .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. This invention also relates to pharmaceutical compositions comprising such compounds as well as methods for inhibiting release of .beta.-amyloid peptide. REFERENCES [0008] The following publications, patents and patent applications are cited in this application as superscript numbers: [0009] .sup.1Glenner, et al., "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein", Biochem. Biophys. Res. Commun., 120:885-890 (1984). [0010] .sup.2 Glenner, et al., "Polypeptide Marker for Alzheimer's Disease and its Use for Diagnosis", U.S. Pat. No. 4,666,829 issued May 19, 1987. [0011] .sup.3 Selkoe, "The Molecular Pathology of Alzheimer's Disease", Neuron, 6:487-498 (1991). [0012] .sup.4 Goate, et al., "Segregation of a Missense Mutation in the Amyloid Precursor Protein Gene with Familial Alzheimer's Disease", Nature, 349:704-706 (1990). [0013] .sup.5 Chartier-Harlan, et al., "Early-Onset Alzheimer's Disease Caused by Mutations at Codon 717 of the .beta.-Amyloid Precursor Protein Gene", Nature, 353:844-846 (1989). [0014] .sup.6 Murrell, et al., "A Mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease", Science, 254:97-99 (1991). [0015] .sup.7 Mullan, et al., "A Pathogenic Mutation for Probable Alzheimer's Disease in the APP Gene at the N-Terminus of .beta.-Amyloid, Nature Genet., 1:345-347 (1992). [0016] .sup.8 Schenk, et al., "Methods and Compositions for the Detection of Soluble .beta.-Amyloid Peptide", International Patent Application Publication No. WO 94/10569, published 11 May 1994. [0017] .sup.9 Selkoe, "Amyloid Protein and Alzheimer's Disease", Scientific American, pp. 2-8, November, 1991. [0018] .sup.10 Losse, et al., Tetrahedron, 27:1423-1434 (1971). [0019] .sup.11 Citron, et al., "Mutation of the .beta.-Amyloid Precursor Protein in Familial Alzheimer's Disease Increases .beta.-Protein Production, Nature, 360:672-674.(1992). [0020] .sup.12 Hansen, et al., "Reexamination and Further Development of a Precise and Rapid Dye Method for Measuring Cell Growth/Cell Kill", J. Immun. Meth., 119:203-210 (1989). Continue reading about Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis... Full patent description for Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis patent application. ### 1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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