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Method for preparing therapeutic agent for cancerRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Inorganic Active Ingredient Containing, Heavy Metal Or Compound ThereofMethod for preparing therapeutic agent for cancer description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070154566, Method for preparing therapeutic agent for cancer. Brief Patent Description - Full Patent Description - Patent Application Claims
TECHNICAL FIELD [0001] The present invention relates to a method of producing a material for cancer treatment to be used for cancer treatment such as radiation therapy and thermotherapy. BACKGROUND ART [0002] [Patent Document 1] JP06-62439,B [0003] [Patent Document 2] JP02-119784,A [0004] [Patent Document 3] JP2000-258596,A [0005] [Non-Patent Literature Document 1] Chemical Industry, Vol. 52, No. 5 (2001) 38-43 [0006] [Non-Patent Literature Document 2] Journal of Chemical Engineering of Japan, Vol. 26, No. 2 (1993) 223-224 [0007] [Non-Patent Literature Document 3] New Ceramics, (1993) No. 1, 47-50 [0008] [Non-Patent Literature Document 4] Annual Meeting of The Ceramic Society of Japan (2001) 270 [0009] [Non-Patent Literature Document 5] "Preparation of magnetite microspheres for hyperthermia of cancer," pp. 645-648 in Bioceramics Vol. 14, Ed. by S. Brown, I. Clarke and P. Williams, Trans Tech Publications Ltd., Switzerland, 2001 [0010] Since the medical treatment method carried out by sending microspheres made of a radioactive material to a diseased part by a catheter via a blood vessel and directly radiating radioactive beam to a cancer is capable of radiating a sufficient dose of radioactive beam to the diseased part without damaging the normal tissues in the vicinity of the body surface as compared with radiation therapy by radiating radioactive beam from the outside, its application is highly expected. Also, since a medical treatment method carried out by sending microspheres made of a ferromagnetic material to a diseased part by a catheter via a blood vessel and locally heating the diseased part by setting the diseased part in an alternating magnetic field is capable of heating the diseased part deep in vivo without damaging the normal tissues as compared with treatment by heating from the outside of the living body, the application is expected. [0011] As the above-mentioned radioactive material, an yttria-containing glass (Patent Document No. 1) and a crystalline yttria (Patent Document No. 2) produced by high frequency induced thermal plasma method are proposed. Also, as the ferromagnetic material, magnetite-containing glass-ceramics and a magnetite crystal produced by high frequency induced thermal plasma method (both non-Patent Literature Document No. 1), and a magnetite crystal precipitated from an aqueous solution (non-Patent Literature Document No. 5) are proposed. DISCLOSURE OF THE INVENTION [0012] However, the above-mentioned materials have high specific gravity values and clog a catheter and thus are hard to send prescribed amount of microspheres to a diseased part. Further, the sent microspheres descend in a body of a patient owing to the self-weight without staying in the diseased part and their distribution becomes uneven. [0013] Therefore, an object of the invention is to provide a material for cancer treatment easy to be transported by means of a catheter and prone to stay in a diseased part. [0014] To achieve the object, the method for the production of the material of the invention comprises preparing a first aqueous solution and a second aqueous solution; obtaining a precipitate by adding the second aqueous solution to the first aqueous solution; and drying the obtained precipitate. [0015] The first aqueous solution is obtained by dissolving a metal becoming insoluble in an alkaline solution and a carboxylic acid amide under acidic or neutral condition. [0016] The second aqueous solution is obtained by dissolving an enzyme catalyzing hydrolysis of the carboxylic acid amide and an organic polymer becoming gel by reaction with a component of the first aqueous solution or energy application from the outside. [0017] Hereinafter, the case that the organic polymer becomes gel by reaction with the component of the first aqueous solution and the case that the organic polymer becomes gel by energy application from the outside will be described separately. In the case of the former, when the second aqueous solution is added to the first aqueous solution, the second aqueous solution takes the first aqueous solution therein to be gel. In the case the second aqueous solution to be added is in droplet state, gelation occurs in granular form. The carboxylic acid amide held in the gel is hydrolyzed by the function of the enzyme and the produced hydroxide ion increases the pH of the first aqueous solution. Then, the metal ionized and dissolved in the first aqueous solution is bonded with the hydroxide ion to form a precipitate. Since the above-mentioned enzyme is fixed in gel (particles), the hydrolysis is promoted only in the inside of the gel (particles) and in the vicinity of the gel (particles) to produce a precipitate reflecting the shape of the gel (particles). Since the gel (particles) is porous, the precipitate becomes porous and thus its specific gravity is small. [0018] If the above-mentioned metal is yttrium, yttria particles having radioactive property can be produced and if iron, magnetite (Fe.sub.3O.sub.4) or maghemite (.gamma.-Fe.sub.2O.sub.3) particle showing magnetic property can be produced. Besides, zinc, magnesium, and manganese may be contained. [0019] If the metal is derived from a nitric acid salt, the salt is easy to be dissolved in the first aqueous solution and therefore it is preferable. The carboxylic acid amide is defined in a broad definition including urea and may include all those which are defined by the general formula RCONH.sub.2. In the formula, R is not particularly limited and may be residual groups formed by removing the carboxyl group from carboxylic acid and besides, an amino group. In the case R is amino, it becomes urea. [0020] Preferable as the above-mentioned organic polymer are an alginic acid salt and an alkyl cellulose derivative salt, because they carry out gelation by reaction with iron ion and yttrium ion, respectively. [0021] Next, the case of carrying out gelation by energy application will be described. If the organic polymer is an albumin, gelation takes place by moderate heating and if an agar or a gelatin, gelation takes place by cooling. In the case gelation of the organic polymer is caused by the energy application from the outside, it is preferable to add the organic polymer to the first aqueous solution after previous generation by the method. Further, if the organic polymer is a pectic acid, gelation is carried out by reaction with saccharides and if a carrageenan, gelation is carried out by reaction with potassium ion under cooling condition. In these cases, the saccharides or potassium ion may be added previously in the first aqueous solution. The saccharides can be removed by firing after the precipitate is produced. Continue reading about Method for preparing therapeutic agent for cancer... Full patent description for Method for preparing therapeutic agent for cancer Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Method for preparing therapeutic agent for cancer patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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