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Medicaments containing pantothenic acidRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Radical -xh Acid, Or Anhydride, Acid Halide Or Salt Thereof (x Is Chalcogen) Doai, Carboxylic Acid, Percarboxylic Acid, Or Salt Thereof (e.g., Peracetic Acid, Etc.), Nitrogen Other Than As Nitro Or Nitroso Nonionically BondedMedicaments containing pantothenic acid description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070191484, Medicaments containing pantothenic acid. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. application Ser. No.: 10/088,339, filed on Sep.10, 2002, which is the National Stage of International Application No.: PCT/GB00/03490, filed on Sep. 12, 2000, which claims the benefit of Great Britain Application No.: GB 9921985.9, filed on Sep. 16, 1999. Each of these three prior applications is incorporated herein by reference in its entirety. TECHNICAL FIELD [0002] This invention relates to medicaments and their use in the alleviation of inflammation and pain in joints. BACKGROUND [0003] Pain or loss of movement in joints is a common occurrence, particularly among the elderly or those who have suffered damage to cartilage, bone surfaces or ligaments. Standard methods of treatment include the administration of corticosteroids by injection into the site of the inflammation. However, relief tends to be temporary and long term use can carry a number of contraindications. [0004] Pantothenic acid (sometimes known as vitamin B5) and its salts have been used as a dietary supplement and for treatment of bronchial asthma, hay-fever, sinusitis and neurodermatitis. SUMMARY [0005] It has now been found that pantothenic acid (or a pharmaceutically acceptable salt and/or a derivative or prodrug there of), when injected into an affected joint or in the region of an affected joint (e.g., a joint affected by, e.g., inflamed by, traumatic arthritis), can be used to treat (e.g., control, ameliorate, alleviate, reduce, eliminate, prevent, or delay the onset of) pain or inflammation associated with the affected joint. [0006] Accordingly, in one aspect, this invention relates to the use of pantothenic acid or a derivative thereof (e.g., a pharmaceutically acceptable salt or prodrug there of) in the preparation of a medicament for administration by injection into the region of ajoint for alleviation of inflammation or pain. [0007] In another aspect, this invention relates to a method of alleviating pain in an inflamed or painful joint of a mammal, which includes the administration of an effective amount of pantothenic acid or a derivative thereof by injection into the region of an inflamed or painful joint to obtain alleviation of said inflammation or pain. [0008] In a further aspect, this invention relates to a method of alleviating inflammation and pain in an inflamed and painful joint of a mammal, which includes administration of an injectable composition consisting essentially of an effective amount of pantothenic acid or a derivative thereof, a solvent therefor, and an adjuvant selected from cysteine and glucosamine by injection into the region of an inflamed and painful joint to obtain alleviation of said inflammation and pain. [0009] In one aspect, this invention relates to a method of alleviating inflammation and pain in an inflamed and painful joint of a mammal, which includes administration of an injectactable composition that includes about 500 mg of pantothenic acid or a derivative thereof and a solvent therfor by injection into the region of an inflamed and painful joint to obtain alleviation of said inflammation and pain. [0010] In another aspect, this invention relates to a method of alleviating inflammation and pain in an inflamed and painful joint of a mammal, the method consisting of administration of an injectactable composition consisting of an effective pain relief amount of pantothenic acid or a derivative thereof and a solvent therfor by injection into the region of an inflamed and painful joint to obtain alleviation of said inflammation and pain. [0011] In a further aspect, this invention relates to the use of pantothenic acid (or a pharmaceutically acceptable salt and/or a derivative or prodrug there of) in the preparation of a medicament (e.g., an injectable composition) for administration by injection into ajoint or into a body region that is closely adjacent to the joint for treatment (e.g., alleviation) of pain in a joint affected by (e.g., inflamed by) traumatic arthritis. The medicament or composition can include at least about 400 milligrams of pantothenic acid (or a pharmaceutically acceptable salt or prodrug there of). [0012] In one aspect, this invention relates to a method of treating pain in ajoint inflamed by traumatic arthritis which includes injecting a solution that includes at least about 400 mg of pantothenic acid (or a pharmaceutically acceptable salt and/or a derivative or prodrug there of) into the inflamed joint, or injecting the solution into a site that is next to the inflamed joint but outside the capsule of the inflamed joint. [0013] Embodiments can include one or more of the following features. [0014] The joint can be affected by a disorder selected from tennis elbow, housemaid's knee, frozen shoulder, inflamed knee joints, and hip and/or back pain associated with inflammation or restricted movement in the spinal vertebrae (e.g., inflammation of spinal vertebrae). [0015] The derivative can be a salt of pantothenic acid (e.g., a calcium salt). [0016] The pantothenic acid or a derivative thereof can be administered as an aqueous solution. [0017] The effective amount of pantothenic acid or a derivative thereof can be about 500 milligrams (mg). [0018] The solution can be injected into a site that is next to the inflamed joint but outside the capsule of the inflamed joint. For example, the solution is injected into a site that is outside the capsule of the inflamed joint and within about 10 millimeters from the exterior surface of the capsule of the joint. [0019] The pantothenic acid (or a pharmaceutically acceptable salt or prodrug thereof) can be the dextrorotatory isomer of pantothenic acid. In other embodiments, a pantothenic acid racemic mixture or an optically active dextrollevo pantothenic acid enantiomer mixture that includes >50% of the dextro enantiomer can be administered (also in the form of a salt or prodrug). [0020] The pantothenic acid or a derivative thereof can be co-administered with a local anesthetic. In some embodiments, the local anesthetic can be co-administered as a separate injection. The pantothenic acid or the pharmaceutically acceptable salt thereof can be co-formulated with a local anaesthetic. Continue reading about Medicaments containing pantothenic acid... Full patent description for Medicaments containing pantothenic acid Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Medicaments containing pantothenic acid patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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