| Material delivery system -> Monitor Keywords |
|
|
 
Material delivery systemRelated Patent Categories: Surgery, Instruments, Internal Pressure Applicator (e.g., Dilator), Inflatable Or Expandible By FluidMaterial delivery system description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060190022, Material delivery system. Brief Patent Description - Full Patent Description - Patent Application Claims
RELATED APPLICATIONS [0001] The present application is a continuation in part of PCT application IL/2005/000749 filed on Jul. 14, 2005 which claims the benefit under 119(e) of 60/587,335 filed Jul. 14, 2004, 60/599,884 filed Aug. 10, 2004, 60/603,262 filed Aug. 23, 2004 and 60/675,477 filed Apr. 28, 2005, an inventor common to all of these applications is Mordechay Beyar, the disclosures of which are incorporated herein by reference. FIELD OF THE INVENTION [0002] The present invention relates to the delivery of materials, for example, high speed intrabody needle-less injection. BACKGROUND OF THE INVENTION [0003] A common treatment for a blocked artery, especially a coronary artery, is PTCA, in which a balloon is inflated inside the lumen of the artery, causing the lumen to increase, while compressing the blockage and/or forcefully expanding the artery. One problem with this method is restenosis, in which the artery responds to the PTCA procedure by inflammation and inward growth. Another problem is collapse of the wall of the artery back into its lumen. [0004] The use of a stent attempts to help with one or both problems, by providing continual support against collapse. Restenosis may still occur and common practices are coating the stent with a material that prevents vessel growth and/or using local irradiation for the same effect. Some problems have been reported with these methods, for example, thrombosis formation. [0005] Injection of drugs from outside the body using needle-less methods is known in the art. [0006] US application publication 2003/0083612, the disclosure of which is incorporated herein by reference describes a needle-less device for injecting drugs from outside the body. [0007] Injection of materials inside the body is also generally known. [0008] T. Hirano, A. Nakagawa, H. Ohyama, H. Jokura, K. Takayama and R. Shirane "Pulsed liquid jet dissector using holmium: YAG laser--a novel neurosurgical device for brain incision without impairing" Acta Neuroehir (2003) 145: 401-406, the disclosure of which is incorporated herein by reference, describes the use of a Ho: YAG laser to evaporate water in a tube and thereby creates a forward (tube axis) plume of material. [0009] Takayuki Hirano, M D, Makoto Komatsu, Toshiro Seaeki, Hiroshi Uenohara, Akira Takahashi, Kazuyoshi Takayama and Takashi Yoshimoto "Enhancement of Fibrinolytics With a Laser-Induced Liquid Jet" Lasers in Surgery and Medicine 29:360-368 (2001), the disclosure of which is incorporated herein by reference describes the forward injection of a thrombosis dissolving material. [0010] U.S. Pat. No. 5,614,502 Mar. 25, 1997 "High pressure impulse transient drug delivery for the treatment of proliferative diseases" and U.S. Pat. No. 6,716,190 Apr. 6, 2004 "Device and method for the delivery and injection of therapeutic and diagnostic agents to a target site within a body", the disclosures of which are incorporated herein by reference, describe methods of material delivery inside the body, including transvascularly. [0011] W. J. Walker, I. M. Faireley "A simplified technique for the per catheter delivery of Isobutyl 2--Cyanoacrylate in the Embolisation of Bleeding Vessels", Journal of Interventional Radiology 1987 2, 59-63, the disclosure of which is incorporated herein by reference, describes the injection of glue into a lumen and against walls of an artery, in order to block it. [0012] U.S. Pat. No. 6,280,414, the disclosure of which is incorporated herein by reference describes a tube system for delivering a drug to the wall of a blood vessel. [0013] U.S. Pat. No. 5,713,860 issued to Kaplan, the disclosure of which is incorporated herein by reference, teaches a lumen based system including a balloon to deliver medication. [0014] U.S. Pat. NO. 5,611,775, the disclosure of which is incorporated herein by reference teaches methods of delivery of therapeutic or diagnostic liquid into tissue surrounding a body lumen. The methods include providing a catheter having an expandable member with a plurality of small apertures and advancing this catheter into the body. The member is expanded to touch or approach the lumen wall. This patent teaches use of pressures in the range of 0.75 to 10 atmospheres to create a velocity of 0.5 to 15 M/s in material ejected through the apertures. [0015] In other clinical scenarios, it is common to employ medicines or methods which are not cell type specific in order to eliminate a certain type of cell. Many chemotherapeutic agents are generally cytotoxic. Systemic administration of these compounds causes undesirable side effects such as nausea, hair loss, appetite suppression, weight loss and lethargy. In certain types of cancer, such as urinary bladder cancer, an intrabody lumen may be infused or "washed" with a chemotherapeutic agent in order to limit systemic toxic effects. In additional clinical scenarios, a mucosal layer covering cells lining a lumen reduces a potential efficacy of "washing". SUMMARY OF THE INVENTION [0016] An aspect of some embodiments of the present invention relates to injecting a medicament into a target tissue by retaining the medicament within an intra-body balloon until a desired pressure is achieved and then providing a plurality of apertures through which the medicament may exit. In an exemplary embodiment of the invention, the medicament exits the balloon through the apertures at a desired velocity. Optionally, the pressure is further increased after the apertures are provided. Optionally, the desired pressure is 15 atmospheres or more. Optionally, the desired velocity is 10, optionally 20, optionally 60 M/s or more. Optionally, at least a portion of the medicament is injected intracellularly. [0017] In an exemplary embodiment of the invention, the target tissue is located in a body lumen. Optionally, the injection is transaxial or radial with respect to the balloon. Optionally, the injection is axial with respect to the balloon. Optionally the body lumen is a blood vessel (e.g. coronary artery, pulmonary vein or peripheral blood vessel), a prostate gland, a urinary bladder, a nostril, a nasal sinus, an ear canal, an airway, a portion of the digestive tract or a portion of the female reproductive tract. Optionally, the medicament is a cytotoxic agent, for example Rapamycin or Paclitaxel. Optionally, the medicament is a fibrotic agent, optionally including collagen and/or elastin. [0018] In an exemplary embodiment of the invention, a cytotoxic agent is injected into a target tissue. Optionally the target tissue is a portion of a blood vessel wall. Optionally the blood vessel is a pulmonary vein. Optionally, the injection causes ablation of a portion of the vessel wall. Optionally, the injection prevents transmission of an electric signal. Optionally, the velocity of injected material may reach 20 m/s, 30 m/s, 50 m/s, 100 m/s, 150 or 200 m/s or smaller, intermediate or larger speeds. In an exemplary embodiment of the invention, the cytotoxic agent contains an alcohol, optionally ethanol. [0019] In an exemplary embodiment of the invention, ablated tissue in the pulmonary vein blocks transmission of an electric signal. Optionally, blocking of the signal relieves symptoms of Atrial Fibrillation. [0020] In an exemplary embodiment of the invention, the target tissue is a tumor located on an inner surface of a urinary bladder. Continue reading about Material delivery system... Full patent description for Material delivery system Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Material delivery system patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Material delivery system or other areas of interest. ### Previous Patent Application: Cutting device for subcutaneous incisions Next Patent Application: Methods and devices for changing the shape of a medical device Industry Class: Surgery ### FreshPatents.com Support Thank you for viewing the Material delivery system patent info. IP-related news and info Results in 0.12455 seconds Other interesting Feshpatents.com categories: Accenture , Agouron Pharmaceuticals , Amgen , AT&T , Bausch & Lomb , Callaway Golf 174 |
 * Protect your Inventions * US Patent Office filing 
PATENT INFO |
|
