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Lactam-containing compounds and derivatives thereof as factor xa inhibitorsRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered And Includes At Least Nitrogen And Oxygen As Ring Hetero Atoms (e.g., Monocyclic 1,2- And 1,3-oxazines, Etc.), Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., Maytansinoids, Etc.), Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., 1,4-benzoxazines, Etc.)Lactam-containing compounds and derivatives thereof as factor xa inhibitors description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20050261287, Lactam-containing compounds and derivatives thereof as factor xa inhibitors. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 10/970,807, filed Oct. 21, 2004, now allowed, which is a continuation of U.S. application Ser. No. 10/245,122, filed Sep. 17, 2002, now allowed, which claims the priority of U.S. Provisional Application No. 60/324,165, filed Sep. 21, 2001 and the priority of U.S. Provisional Application No. 60/402,317, filed Aug. 9, 2002, the contents of which are fully incorporated herein by reference. FIELD OF THE INVENTION [0002] This invention relates generally to lactam-containing compounds and derivatives thereof which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment of thromboembolic disorders. BACKGROUND OF THE INVENTION [0003] WO94/20460 describes angiotensin II compounds of the following formula: 1 [0004] wherein X can be a number of substituents and Het can be a nitrogen-containing heterobicycle. However, WO94/20460 does not suggest Factor Xa inhibition or exemplify compounds like those of the present invention. [0005] WO96/12720 depicts phosphodiesterase type IV and TNF production inhibitors of the following formula: 2 [0006] wherein X can be oxygen and R.sup.2 and R.sup.3 can a number of substituents including heterocycle, heterocycloalkyl, and phenyl. However, the presently claimed compounds do not correspond to the compounds of WO96/12720. Furthermore, WO96/12720 does not suggest Factor Xa inhibition. [0007] WO98/52948 details inhibitors of ceramide-mediated signal transduction. One of the types of inhibitors described is of the following formula: 3 [0008] wherein Y.sub.1 can be N--R.sub.6, R.sub.6 can be unsubstituted aryl-alkyl or unsubstituted heterocyclic-alkyl and R.sub.1 can be a substituted aryl group. WO98/52948 does not mention factor Xa inhibition or show compounds like those of the present invention. [0009] U.S. Pat. Nos. 3,365,459, 3,340,269, and 3,423,414 illustrate anti-inflammatory inhibitors of the following formula: 4 [0010] wherein A is 2-3 carbon atoms, X can be O, and R.sup.1 and R.sup.3 can be substituted or unsubstituted aromatic groups. Neither of these patents, however, exemplifies compounds of the present invention. [0011] WO99/32477 reports Factor Xa inhibitors of the following formula: 5 [0012] wherein the inhibitors contain at least three aryl or heterocyclic groups (i.e., C, B, and R.sup.3) separated by two linking groups (i.e., E and D). Compounds of this sort are not considered to be part of the present invention. [0013] WO00/39131 describes heterobicyclic Factor Xa inhibitors of which the following is an example formula: 6 [0014] wherein Z is C or N, G is a mono- or bicyclic group, A is a cyclic moiety and B is a basic group or a cyclic moiety. Compounds specifically described in WO00/39131 are not considered to be part of the present invention. [0015] WO98/28269, WO98/28282, WO99/32454, U.S. Pat. No. 6,020,357, and U.S. Pat. No. 6,271,237 describe Factor Xa inhibitors of the following formula: 7 [0016] wherein ring M is a heterocycle, Z is a linker, A is a ring, B is a basic or cylic group, D is a basic moiety, and E is a ring. Compounds specifically described in WO98/28269, WO98/28282, WO99/32454, U.S. Pat. No. 6,020,357, and U.S. Pat. No. 6,271,237 are not considered to be part of the present invention. [0017] WO98/57951 describes Factor Xa inhibitors of the following formula: 8 [0018] wherein ring M can be a variety of heterocycles and rings D-E represent a heterobicyclic group. Compounds specifically described in WO98/57951 are not considered to be part of the present invention. [0019] WO98/57934 and U.S. Pat. No. 6,060,491 describe Factor Xa inhibitors of the following formula: 9 [0020] wherein ring M is a 6-membered heteroaryl, Z is a linker, A is a ring, B is a basic or cylic group, D is a basic moiety, and E is a ring. Compounds specifically described in WO98/57934 and U.S. Pat. No. 6,060,491 are not considered to be part of the present invention. [0021] WO98/57937 and U.S. Pat. No. 5,998,424 describe Factor Xa inhibitors of the following formula: 10 Continue reading about Lactam-containing compounds and derivatives thereof as factor xa inhibitors... 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