| Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents -> Monitor Keywords |
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  Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agentsRelated Patent Categories: Surgery, Means For Introducing Or Removing Material From Body For Therapeutic Purposes (e.g., Medicating, Irrigating, Aspirating, Etc.), Treating Material Introduced Into Or Removed From Body Orifice, Or Inserted Or Removed Subcutaneously Other Than By Diffusing Through Skin, Material Introduced Or Removed Through Conduit, Holder, Or Implantable Reservoir Inserted In Body, Body Piercer, Obturator Rod, Or Stylet Axially Movable Within Body Entering Conduit While Latter Is Disposed In Body, Having Additional Body Entering ConduitInjection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060206056, Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents. Brief Patent Description - Full Patent Description - Patent Application Claims
RELATED APPLICATION [0001] This application is a Continuation of U.S. application Ser. No. 10/215,034, filed on Aug. 9, 2002, incorporated herein in its entirety. FIELD OF THE INVENTION [0002] The present invention relates to injection devices that provide reduced leakage of therapeutic agents from an injection site resulting in increased agent uptake. According to embodiments of the present invention injection devices are provided having at least two lumens containing one or more therapeutic agents in at least one lumen and at least a second material for injection in at least one other lumen. Other embodiments include injection devices having at least one lumen containing one or more therapeutic agents and an outer lumen adapted to provide a vacuum seal between an injection needle and the needle track it creates. [0003] The present invention also relates to methods for delivering therapeutic agents to a tissue. Embodiments of the present invention include injecting at least one therapeutic agent into tissue and injecting at least one second material to the tissue. Other embodiments include creating a vacuum between an injection needle and the needle track it creates to reduce potential leakage of the therapeutic agent. BACKGROUND OF THE INVENTION [0004] The treatment of disease such as vascular disease by local pharmacotherapy presents a means of delivering therapeutic drug doses to target tissues while minimizing systemic side effects. Such localized delivery of therapeutic agents has been proposed or achieved using medical devices such as catheters, needle devices and various coated implantable devices such as stents. [0005] The localized delivery of therapeutic agents using needle devices has the advantages of precise placement and accurate control over the volume and rate of delivery. However, delivery using needle devices creates a needle track, which allows leakage or outflow of the therapeutic agent. SUMMARY OF THE INVENTION [0006] Embodiments of the present invention include injection devices that include at least a first lumen containing at least one therapeutic agent for injection into a tissue and a second lumen containing at least a second material for injection into the tissue. The depth and deployment of each lumen into tissue is controlled together or preferably independently from one another. The injection device optionally includes a third lumen containing a third material for injection into the material. [0007] In other embodiments, the present invention includes injection devices that include an injection needle at a distal end of an inner lumen adapted to inject one or more therapeutic agents into tissue, an outer lumen adapted to provide a vacuum seal between the injection needle and a needle track it creates, and a vacuum-creating device for creating a vacuum in the outer lumen. These devices optionally include one or more gaskets to aid in forming the seal. [0008] In other embodiments, the invention includes methods of delivering one or more therapeutic agents to tissue with an injection device. These methods include injecting at least one therapeutic agent into tissue, preferably tissue of a mammal, from a first lumen of an injection device and injecting at least one second material into the tissue from a second lumen of the injection device. The second material may be injected after, before, or substantially concurrently with injection of the therapeutic agent. The composition and amount of the second material and timing of its injection with respect to the injection of the therapeutic agent, are selected so as to reduce leakage of the therapeutic agent(s) from the injection site. [0009] Further embodiments of the present invention include other methods of delivering therapeutic agent(s) to tissue. These methods include deploying a needle from a needle injection device at the distal end of an inner lumen into tissue, thus forming a needle track; establishing a vacuum in an outer lumen of the injection device to create a vacuum seal between the needle track and the needle; injecting at least one therapeutic agent into tissue from the inner lumen; and releasing the vacuum seal. BRIEF DESCRIPTION OF THE DRAWINGS [0010] FIG. 1 depicts an injection device according to the present invention having a first lumen 1 containing at least one therapeutic agent and a second lumen 2 containing at least one second material outside the first lumen. [0011] FIG. 2 depicts an injection device according to the present invention having a third lumen containing a third material for injection, where the second material and third material combine to form a plug 4. [0012] FIG. 3 depicts another injection device according to the present invention. In this embodiment the second material is relatively viscous and provides resistance to outflow of therapeutic agent. [0013] FIG. 4 depicts the injection device of FIG. 3 having a second material 5 blocking outflow of therapeutic agent. [0014] FIG. 5 depicts an injection device according to the present invention having an inner lumen 8 that contains therapeutic agent and an outer lumen 6 through which a vacuum may be formed. This embodiment also has gaskets 7. [0015] FIG. 6 is a sectional view of another embodiment of the invention. In this embodiment the walls of the outer lumen 6 have openings 16 to provide communication between the negative pressure created in the outer lumen and the needle track. [0016] FIG. 7 shows a portion of the injection device of FIG. 6. This view shows the openings as being holes aligned substantially circumferentially, and further shows gaskets on two sides of the holes. [0017] FIG. 8 is a sectional view of a catheter of the injection device (as in FIG. 6) meeting up with and being attached to a handle designed so as to create and maintain a negative pressure in the outer lumen of the device with a plunger 20 and ratchet 22. DETAILED DESCRIPTION [0018] When therapeutic agents are delivered to target tissue with an injection device such as a needle, leaking and dispersion often result upon removal of the device from the tissue. For example, a needle track is formed in tissue after a therapeutic agent has been injected into a tissue with an injection device and subsequently removed from the tissue. Therefore, where an injection is performed via a needle, there is potential for leakage of the administered therapeutic agent along the needle track left by needle withdrawal. Continue reading about Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents... Full patent description for Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. 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