Inhibitors of matrix metalloproteinase

Title: Inhibitors of matrix metalloproteinase

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20080227858, Inhibitors of matrix metalloproteinase.

1. A compound of formula (I): wherein: R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or heteroaryl; Z represents a bond, CH2, O, S, SO, SO2, NR4, OCR4R5, CR4R50, or Z, R1 and Q together form an optionally substituted fused tricyclic group; Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents COR3 or N(OR8)COR9; R2 represents SO2R10 or SO2NR10R9; R3 represents OR6, NR6R7 or NR6OH; R4 and R5 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; R6 and R7 each independently represents H, C1-6 alkyl, or C1-6 alkyl substituted with one or more heteroaryl groups, or R6 and R7 together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; R8 and R9 each independently represents H or C1-6 alkyl; R10 and R11 each independently represents H or C1-6 alkyl; and and physiologically functional derivatives thereof, with the exception of N-(ethoxycarbonyl)-N-[4-(1H-tetrazol-1-yl)phenyl]glycine.

2. A compound of formula (Ia): wherein: R10 represents H or C1-6 alkyl; R12 represents H, halo, CF3, cyano, OCF3, nitro, OR3, SR3, COR13 or C1-6 alkyl; R13 represents C1-6 alkyl or C1-4alkylaryl; and physiologically functional derivatives thereof.

3. A method for treatment of a human or animal subject suffering from or susceptible to an autoimmune disorder or an inflammatory condition, which comprises administering to said human or animal subject an effective amount of a compound of claim 1.

4. A pharmaceutical composition, comprising a compound of claim 1 and a pharmaceutically acceptable carrier therefor, and optionally one or more other therapeutic agents.

5. A process for preparation of compounds of formula (I) according to claim 1, which comprises: (A) preparing a compound of formula (I), wherein Z represents a bond and R1 represents an optionally substituted C2-6alkylaryl or an optionally substituted 5- or 6-membered aryl or heteroaryl, by reacting a compound of formula (II): wherein R2, Q and X are as previously defined for formula (I) and L represents a leaving group, with a reagent suitable to introduce the group R1; or (B) preparing a compound of formula (I), wherein Z represents a bond and R1 represents an optionally substituted C4-12alkyl, by reacting a compound of formula (III): wherein R2, Q and X are as previously defined for formula (I), with a reagent suitable to introduce the group R1; or (C) preparing a compound of formula (I), wherein Z represents OS, SO, SO2, NR4 or OCR4R5, and R1 represents an optionally substituted C4-12alkyl, by reacting a compound of formula (IV): wherein X, R2 and Q are as previously defined for formula (I), and Y represents OH, SH, NR4H or HCR4R5, with a reagent suitable to introduce group R1, provided that when Y is SH it is followed by optional oxidation of sulphide to sulfoxide or sulfone; or (D) preparing a compound of formula (I), wherein Z represents OS, SO, SO2, or NR4, and R1 represents an optionally substituted C2-6alkylaryl or an optionally substituted 5- or 6-membered aryl or heteroaryl, by reacting a compound of formula (IV): wherein X, R2 and Q are as previously defined for formula (I), and Y represents OH, SH or NR4H, with a reagent suitable to couple to group R1, provided that when Y is SH it is followed by optional oxidation of the sulphide to sulfoxide or sulfone; or (E) preparing a compound of formula (I), wherein Z represents OCR4R5 and R1 represents an optionally substituted C2-6alkylaryl or an optionally substituted 5- or 6-membered aryl or heteroaryl, by reacting a compound of formula (V): wherein X, R2 and Q are as defined for formula (I) and L4 is a suitable leaving group, with a reagent suitable to introduce group R1—O; or (F) preparing a compound of formula (I), wherein Z represents CR4R50, by reacting a compound of formula (IV): wherein R2 and Q are as defined for formula (I), and Y represents OH, with a reagent suitable to introduce group R1CR4R5—; or (G) preparing a compound of formula (I), wherein Z represents CH2, by reacting a compound of formula (III): wherein R2, Q and X are as defined for formula (I), with a reagent suitable to introduce group R1CH2; (H) reacting a compound of formula (VI) or a protected derivative thereof, wherein R1, Z, Q and X are as defined for formula (I), with a reagent suitable to introduce group R2 as defined for formula (I): or (J) carrying out a process selected from processes (A) to (G) followed by interconversion of one or more functional groups.

Brief Patent Description - Full Patent Description - Patent Claims

Click on the above for other options relating to this Inhibitors of matrix metalloproteinase patent application.
###

How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.
Start now! - Receive info on patent apps like Inhibitors of matrix metalloproteinase or other areas of interest.
###

Previous Patent Application:
N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use
Next Patent Application:
Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
Industry Class:
Drug, bio-affecting and body treating compositions

###

Design/code © 2009 FreshContext LLC/Freshpatents.com. Website Terms and Conditions - Also read: About this Page
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and often contain additional data/images (Freshpatents is currently text-only). FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents.

FreshPatents.com Support
Thank you for viewing the Inhibitors of matrix metalloproteinase patent info.
IP-related news and info

Results in 0.07647 seconds

Other interesting Feshpatents.com categories:
Computers: Graphics , I/O , Processors , Dyn. Storage , Static Storage , Printers 174

* Protect your Inventions
* US Patent Office filing

Provisional Patent
Utility Patent

PATENT INFO