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Inhibitors of matrix metalloproteinaseInhibitors of matrix metalloproteinase description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20080227858, Inhibitors of matrix metalloproteinase. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS REFERENCE TO PRIOR APPLICATIONS
This application is a continuation of U.S. application Ser. No. 10/561,055 filed 16 Dec. 2005 (allowed), which is a 371 application of PCT/EP2004/006553 filed 16 Jun. 2004 which claims priority to GB application 0314488.8 filed 20 Jun. 2003. FIELD OF THE INVENTIONThis invention relates to novel chemical compounds, processes for their preparation, pharmaceutical formulations containing them and their use in therapy. SUMMARY OF THE INVENTIONThe compounds of the invention are inhibitors of matrix metalloproteinase enzymes (MMPs). BACKGROUND OF THE INVENTIONMatrix metalloproteinase enzymes play a major role in extracellular matrix component degradation and remodelling. Examples of MMPs include collagenase 1, 2 and 3, gelatinase A and B, stromelysin 1, 2 and 3, matrilysin, macrophage metalloelastase, enamelysin and membrane type 1, 2, 3 and 4 MMP. The enzymes are secreted by connective tissue cells and inflammatory cells. Enzyme activation can not only initiate tissue damage but induce increased inflammatory cell infiltration into the tissue, leading to more enzyme production and subsequent tissue damage. For example, elastin fragments produced by MMP degradation are believed to stimulate inflammation by attracting macrophages to the site of MMP activity. Inhibition of MMPs provides a means for treating disease states wherein inappropriate metalloprotease activity results in degradation of connective tissue and inflammation. DETAILED DESCRIPTION OF THE INVENTIONIn one aspect, the present invention provides compounds of formula (I):
wherein:
R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or heteroaryl;
Z represents a bond, CH2, O, S, SO, SO2, NR4, OCR4R5, CR4R5O, or Z, R1 and Q together form an optionally substituted fused tricyclic group;
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