Immunostimulatory nucleic acid molecules

Title: Immunostimulatory nucleic acid molecules

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), O-glycoside, , Nitrogen Containing Hetero Ring, Polynucleotide (e.g., Rna, Dna, Etc.)

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20050277604, Immunostimulatory nucleic acid molecules.

1-18. (canceled)

19. An immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, comprising: a polynucleotide comprising an immunostimulatory sequence (ISS) linked to a nonbiodegradable microcarrier (MC), wherein the ISS comprises the sequence 5'-C, G-3', with the proviso that if the MC is gold, latex or magnetic, the linkage is other than by biotin/avidin.

20. The IMP/MC complex of claim 19, wherein said polynucleotide is covalently linked to said microcarrier.

21. The IMP/MC complex of claim 19, wherein said polynucleotide is non-covalently linked to said microcarrier.

22. The IMP/MC complex of claim 19, wherein said microcarrier is a liquid phase microcarrier.

23. The IMP/MC complex of claim 19, wherein said complex is antigen-free.

24. The IMP/MC complex of claim 19, wherein the ISS comprises the sequence 5'-T, C, G-3'.

25. The IMP/MC complex of claim 19, wherein the ISS comprises the sequence 5'-purine, purine, C, G, pyrimidine, pyrimidine, C, G-3'.

26-56. (canceled)

57. An immunostimulatory nucleic acid/delivery complex comprising: a nucleic acid comprising an immunostimulatory nucleic acid linked to a nucleic acid delivery complex, wherein the immunostimulatory nucleic acid comprises the sequence 5.degree. C., G 3'.

58. The complex of claim 57, wherein the immunostimulatory nucleic acid is covalently linked to the nucleic acid delivery complex.

59. The complex of claim 57, wherein the immunostimulatory nucleic acid is non-covalently linked to the nucleic acid delivery complex.

60-78. (canceled)

79. The IMP/MC complex of claim 19, wherein said polynucleotide comprises a phosphate backbone modification.

80. The IMP/MC complex of claim 79, wherein said phosphate backbone modification is a phosphorothioate.

81-88. (canceled)

89. An immunomodulatory polynucleotide/microcarrier (IMP/MC) complex, comprising: a polynucleotide linked to a silica microcarrier (MC), wherein the polynucleotide is 2-100 nucleotides in length and comprises the sequence 5'-X.sub.1 X.sub.2CGX.sub.3X.sub.4-3', wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are nucleotides.

90. The IMP/MC complex of claim 89, wherein said polynucleotide comprises a phosphate backbone modification.

91. The IMP/MC complex of claim 90, wherein said phosphate backbone modification is a phosphorothioate.

92. The IMP/MC complex of claim 89, wherein said polynucleotide comprises the sequence 5' purine, purine, C, G, pyrimidine, pyrimidine 3'.

93. A composition comprising the IMP/MC complex of claim 19 and a pharmaceutically acceptable excipient.

94. The composition of claim 93 wherein the composition is antigen free.

95-96. (canceled)

95-96. (canceled)

Brief Patent Description - Full Patent Description - Patent Claims

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