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Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane




Title: Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane.
Abstract: The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Tmax within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of Tmax. ...


- New York, NY, US
Inventors: Yan Yang, Rajiv Janjikhel, Niranjan Rao, Antonia Periclou, Wattanaporn Abramowitz, Mahendra G. Dedhiya, Erhard Seiller, Bernhard Hauptmeier
USPTO Applicaton #: #20060198884
Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Preparations Characterized By Special Physical Form, Tablets, Lozenges, Or Pills
The Patent Description & Claims data below is from USPTO Patent Application 20060198884, Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane.

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stats Patent Info
Application #
US 20060198884 A1
Publish Date
09/07/2006
Document #
File Date
12/31/1969
USPTO Class
Other USPTO Classes
International Class
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Drawings
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20060907|20060198884|immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane|The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following |
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