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Ii-key/antigenic epitope hybrid peptide vaccines

Title: Ii-key/antigenic epitope hybrid peptide vaccines.
Abstract: Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope. In addition, the nucleic acid molecule comprises a second expressible nucleic acid sequence encoding an antigen presentation enhancing hybrid polypeptide. The antigen presentation enhancing hybrid polypeptide includes the following elements: i) an N-terminal element consisting essentially of 4-16 residues of the mammalian Ii-Key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and non-N-terminal deletion modifications thereof that retain antigen presentation enhancing activity; ii) a C-terminal element comprising an MHC Class II-presented epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, the MHC Class II-presented epitope being contained in the protein of interest of step a); and iii) an intervening peptidyl structure linking the N-terminal and C-terminal elements of the hybrid, the peptidyl structure having a length of about 20 amino acids or less. ...
- Portsmouth, NH, US
Inventors: Robert E. Humphreys, Minzhen Xu
USPTO Applicaton #: #20080305122

The Patent Description & Claims data below is from USPTO Patent Application 20080305122, Ii-key/antigenic epitope hybrid peptide vaccines.

Amino Acids   C Peptide   Deletion   Domi   Epitope   MHC   Mhc   Mimetic   Peptidomimetic   PV   PVS   Vaccine   Vaccines   Venin   Advertise on - Rates & Info

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stats Patent Info
Application #
US 20080305122 A1
Publish Date
Document #
File Date
Other USPTO Classes
International Class

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Amino Acids
C Peptide

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