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Heller Ehrman LLP patents

The following is a sampling of recent Heller Ehrman LLP patent applications (USPTO Patent Application #, Patent Title) sorted by month.

May 2009 - Heller Ehrman LLP patents

20090123482 - Assays for determining compounds which modulate tram phosphorylation

April 2009 - Heller Ehrman LLP patents

20090102414 - Solar-powered charger
20090102414 - Solar-powered charger
20090102414 - Solar-powered charger

March 2009 - Heller Ehrman LLP patents

20090076777 - System and method for change detection of information or type of data

February 2009 - Heller Ehrman LLP patents

20090054811 - Method and apparatus for analyte measurement test time
20090055099 - Proteomic analysis of biological fluids
20090055353 - Multi-mode location based e-directory service enabling method, system, and apparatus
20090041791 - Heterocyclic self-immolative linkers and conjugates

January 2009 - Heller Ehrman LLP patents

20090028207 - Mobile charge induced periodic poling and device
20090024173 - Bone plate
20090011988 - Method for treating cartilage disorders

October 2008 - Heller Ehrman LLP patents

20080259969 - Slectable multiwavelength laser for outputting visible light
20080259971 - Method for improving high frequency operation of a vertical cavity surface emitting laser (vcsel) with monolithically integrated bridge arm
20080261694 - Hand-held interactive game
20080249024 - Peptides facilitating or inhibiting a nterograde transport
20080241825 - Materials and methods for treatment of cancer

September 2008 - Heller Ehrman LLP patents

20080231942 - Mobile charge induced periodic poling and device
20080226659 - Methods of treatment using anti-erbb antibody-maytansinoid conjugates
20080227471 - Method for tracking credit card fraud
20080220536 - Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
20080214789 - Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy
20080214956 - Methods and apparatus for lancet actuation

August 2008 - Heller Ehrman LLP patents

20080206202 - Methods for application of endogenous or exogenous stem/progenitor or their progeny for treatment of disease
20080208704 - Methods to conduct sales of products or services over a communication network
20080208712 - Computer based systems to conduct sales of products or services over a communication network
20080199886 - Igf binding proteins
20080200653 - Compositions and methods for the diagnosis and treatment of tumor
20080194987 - Method and apparatus for a variable user interface
20080188771 - Methods and apparatus for penetrating tissue
20080188803 - Triple-profile balloon catheter

July 2008 - Heller Ehrman LLP patents

20080178611 - Ecological liquefied natural gas (lng) vaporizer system
20080180782 - Frequency synthesis for acousto-optic devices
20080180881 - Electric double layer capacitance device
20080182275 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20080174736 - Mobile charge induced periodic poling and device
20080176229 - Gene expression markers for response to egfr inhibitor drugs
20080176897 - Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
20080166698 - Antibodies for cancer therapy and diagnosis
20080160021 - Il-17 homologous polypeptides and therapeutic uses thereof
20080160534 - Altering memory by affecting staufen
20080161540 - Il-17a/f heterologous polypeptides and therapeutic uses thereof
20080162268 - Analytical e-commerce processing system and methods
20080162269 - Analytical e-commerce processing system and methods
20080162574 - Analytical e-commerce processing system and methods

June 2008 - Heller Ehrman LLP patents

20080152657 - Donor specific antibody libraries
20080152658 - Stabilized anti-hepatitis b (hbv) antibody formulations
20080153594 - Interactive toy system and methods
20080134795 - Sensors with high temperature piezoelectric ceramics
20080138345 - Compositions and methods for treatment of cancer
20080139080 - Interactive toy system and methods
20080129150 - High temperature sustainable piezoelectric sensors using etched or micromachined piezoelectric films
20080132884 - Systems for treating tissue sites using electroporation
20080132885 - Methods for treating tissue sites using electroporation

May 2008 - Heller Ehrman LLP patents

20080124334 - Isolated nucleic acids, vectors and host cells encoding erbb3 antibodies
20080124739 - Compositions and methods for the diagnosis and treatment of tumor
20080126325 - Process for making software diagnostics more efficient by leveraging existing content, human filtering and automated diagnostic tools
20080119761 - Method and apparatus for penetrating tissue
20080111066 - Derivatization and low level detection of drugs in biological fluid and other solution matrices using a proxy marker
20080108096 - Analytical method
20080108563 - Novel polypeptides having sequence similarity to gdnfr and nucleic acids encoding the same
20080108979 - Flush tip illuminating laser probe treatment apparatus
20080108981 - Shaped tip illuminating laser probe treatment apparatus

April 2008 - Heller Ehrman LLP patents

20080095762 - Glycoprotein compositions
20080096825 - Preparation and use of phlorizin compositions
20080084269 - Highly sensitive piezoresistive element
20080085283 - Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders
20080085854 - Multifunctional protease inhibitors and their use in treatment of disease

March 2008 - Heller Ehrman LLP patents

20080072671 - Leveraged shear mode accelerometers
20080072677 - Bending mode accelerometer
20080076917 - Intermediates of 2-substituted carbapenem derivatives and process for production thereof
20080071620 - System, methods, and apparatus for interactive advertising
20080071783 - System, apparatus, and methods for pattern matching
20080060119 - Deodorizing toilet seat assembly
20080064748 - Substituted enaminones, their derivatives and uses thereof
20080057824 - Nightlight toy

February 2008 - Heller Ehrman LLP patents

20080050748 - Tissue analysis and kits therefor
20080051437 - Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
20080052043 - System and method for change detection of information or type of data
20080045334 - Method for progressive card game tournament
20080045697 - Crystal structure of crig and c3b:crig complex
20080038271 - Extending survival of cancer patients with elevated levels of egf or tgf-alpha
20080039496 - Method of modulating neurite outgrowth by the use of a galanin-3 receptor antagonist
20080040748 - Dynamic rating of content
20080031854 - Thiolated macromolecules and methods of making and using thereof
20080032275 - Interactive system
20080032276 - Interactive system
20080032332 - Antibodies against the pro1754 polypeptides
20080032920 - Macromolecules modified with electrophilic groups and methods of making and using thereof
20080034351 - Process for making software diagnostics more efficient by leveraging existing content, human filtering and automated diagnostic tools

January 2008 - Heller Ehrman LLP patents

20080023410 - Continuous closed-circuit desalination apparatus without containers
20080027004 - Phosphorylated cop1 molecules and uses thereof
20080027385 - Method and apparatus for penetrating tissue
20080020412 - Aurora expression constructs
20080021371 - Methods and systems for treating restenosis using electroporation
20080021490 - Method and apparatus for body fluid sampling and analyte sensing
20080021491 - Method and apparatus for penetrating tissue
20080021492 - Method and apparatus for penetrating tissue
20080014205 - Neutralizing antibodies to influenza viruses
20080015210 - Base-stabilized polyorthoester formulations
20080015571 - Methods and systems for treating tumors using electroporation
20080007705 - In-situ interferometer arrangement
20080009242 - Underground data communications system
20080009458 - Cop1 molecules and uses thereof
20080009892 - Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
20080005172 - Dead reckoning in a gaming environment

December 2007 - Heller Ehrman LLP patents

20070292488 - Method for treatment of wound treatment using aganocides
20070292489 - Method for treatment of wound treatment using aganocides
20070292732 - Carbon-based foam nanocomposite hydrogen storage material
20070279607 - Method and apparatus for self-referenced wafer stage positional error mapping

November 2007 - Heller Ehrman LLP patents

20070275398 - Genes involved estrogen metabolism
20070276290 - Tissue penetrating apparatus
20070270661 - Method and apparatus for monitoring blood flow to the hip joint
20070263424 - Serial bus controller using nonvolatile ferroelectric memory
20070264339 - Base-stabilized polyorthoester formulations
20070264338 - Base-stabilized polyorthoester formulations
20070264593 - Method for manufacturing semiconductor device using immersion lithography process
20070264599 - Method for manufacturing semiconductor device using immersion lithography process with filtered air
20070264705 - Apparatus and method for handling cells, embryos or oocytes
20070265329 - Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (cinv)
20070265436 - Compositions and methods for the diagnosis and treatment of tumor
20070256226 - Toilet accessory with sterilization elements
20070259942 - Use of gal3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods
20070260045 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20070260271 - Device and method for variable speed lancet
20070252199 - Semiconductor device having a recess channel transistor
20070253900 - Nucleic acid and corresponding protein entitled 98p4b6 useful in treatment and detection of cancer
20070255301 - Method and apparatus for a multi-use body fluid sampling device with sterility barrier release

October 2007 - Heller Ehrman LLP patents

20070246774 - Semiconductor device with substantial driving current and decreased junction leakage current
20070249132 - Semiconductor device with fixed channel ions
20070249369 - System and methods for dialing code initiated mobile search
20070249598 - Derivatives of 8-substituted xanthines
20070249962 - Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
20070249963 - Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
20070250383 - Paying for placement for advertising on mobile devices
20070241420 - Semiconductor device and method for fabricating same
20070243632 - Methods for measuring platelet reactivity of patients that have received drug eluting stents
20070244449 - System and method for the prevention of bacterial and fungal infections including urinary tract infections (uti) using n-halogenated amino acids
20070244499 - Methods and apparatus for lancet actuation
20070238096 - Hybrid energy transfer for nucleic acid detection
20070239189 - Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
20070239190 - Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
20070239317 - Artificial-intelligence-based energy auditing, monitoring and control
20070239910 - Input/output byte control device using nonvolatile ferroelectric register
20070232535 - Gfralpha3 and its uses

September 2007 - Heller Ehrman LLP patents

20070221991 - Semiconductor device with increased channel area and decreased leakage current
20070223638 - Isophase multiphase clock signal generation circuit and serial digital data receiving circuit using the same
20070224627 - Facilitation of translocation of molecules through the gastrointestinal tract
20070224762 - Method for manufacturing semiconductor device
20070225510 - Convergent process for the synthesis of taxane derivatives
20070216902 - Reference wafer and process for manufacturing same
20070219350 - Compositions and methods for the diagnosis and treatment of tumor
20070219462 - Methods and apparatus for lancet actuation
20070219463 - Methods and apparatus for lancet actuation
20070219573 - Method and apparatus for penetrating tissue
20070219574 - Method and apparatus for a multi-use body fluid sampling device with analyte sensing
20070212818 - Multi-layer device
20070213374 - Malonamide derivatives
20070213601 - Method and apparatus for penetrating tissue
20070213756 - Method and apparatus for penetrating tissue
20070206168 - Systems and methods for determination of focus and telecentricity, amelioration of metrology induced effects and application to determination of precision bossung curves

August 2007 - Heller Ehrman LLP patents

20070201830 - Systems and methods for production, delivery, recording, and viewing of video and similar content primarily intended to be viewed in step-frame/frame-advance mode
20070203124 - Therapeutic piperazines
20070203154 - Therapeutic compounds
20070203167 - 2-(hetero)-aryl substituted tetrahydrochinoline
20070203895 - Recursive search engine using correlative words
20070204354 - Integrated in vivo animal experimentation systems
20070196363 - Method for making multispecific antibodies having heteromultimeric and common components
20070196366 - Methods for treating cancer using an immunotoxin
20070198121 - Interactive clothing system
20070187269 - Disc packaging device
20070190049 - Use of a33 antigens and jam-it
20070190054 - Prevention and treatment of complement-associated disorders
20070190078 - Filamentous haemagglutinin in the treatment and/or prophylaxis of immune-mediated disorders
20070191270 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20070191423 - Isoquinoline derivatives
20070191444 - Benzimidazolyl derivatives
20070191736 - Method for loading penetrating members in a collection device
20070191737 - Method and apparatus for penetrating tissue
20070192818 - System and method for creating, distributing, and executing rich multimedia applications
20070184095 - Osmium compounds for the treatment of psoriasis
20070184523 - Method for making multispecific antibodies having heteromultimeric and common components
20070184529 - Mammalian cell culture process
20070185412 - Method and apparatus for penetrating tissue
20070177132 - Method and apparatus for self-referenced dynamic step and scan intra-field scanning distortion
20070178141 - Vitamin b12 compositions
20070178543 - Assay methods and materials
20070178552 - Method for making multispecific antibodies having heteromultimeric and common components

July 2007 - Heller Ehrman LLP patents

20070170480 - Nonvolatile ferroelectric memory device
20070170481 - Nonvolatile ferroelectric memory device
20070170522 - Semiconductor device and method for fabricating the same
20070170547 - Semiconductor device and method for fabricating the same
20070172995 - Method for forming fuse of semiconductor device
20070173001 - Method for manufacturing semiconductor device
20070173038 - Method for manufacturing semiconductor device
20070173042 - Method for fabricating semiconductor device
20070173741 - Tissue penetration device
20070173742 - Method and apparatus for penetrating tissue
20070173743 - Method and apparatus for penetrating tissue
20070173931 - Method and apparatus for tissue connection
20070174253 - Online marketplace for animal genetics
20070167402 - Product of coprecipitation of sparingly soluble substance and water-soluble polymer and process for producing the same
20070167432 - Tricyclic triazolobenzapine derivative produced as novel crystalline substance
20070167620 - Crystalline carbapenem intermediate
20070167870 - Method and apparatus for penetrating tissue
20070167871 - Method and apparatus for penetrating tissue
20070167872 - Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
20070167873 - Method and apparatus for penetrating tissue
20070167874 - Method and apparatus for penetrating tissue
20070167875 - Method and apparatus for penetrating tissue
20070160530 - Antibodies and molecules derived therefrom that bind to steap-1 proteins
20070160534 - Methods and compositions for prolonging elimination half-times of bioactive compounds
20070161125 - Proteomic analysis of biological fluids
20070161581 - Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas)
20070162183 - Random access and random load dispensing unit
20070162184 - Random access and random load dispensing unit
20070151865 - Electrolyzer apparatus and method for hydrogen production
20070154475 - Novel polypeptides having sequence similarity to gdnfr and nucleic acids encoding the same
20070155126 - Method for manufacturing semiconductor device with overlay vernier
20070155148 - Method for forming semiconductor device having fin structure
20070156135 - System and methods for treating atrial fibrillation using electroporation

June 2007 - Heller Ehrman LLP patents

20070146219 - Transmission of underwater electromagnetic radiation through the seabed
20070148089 - Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
20070141587 - Gene expression profiling in biopsied tumor tissues
20070141588 - Gene expression profiling in biopsied tumor tissues
20070141589 - Gene expression profiling in biopsied tumor tissues
20070142747 - Method and apparatus for penetrating tissue
20070142748 - Tissue penetration device
20070133253 - Test mode control device using nonvolatile ferroelectric memory
20070133254 - Test mode control device using nonvolatile ferroelectric memory
20070134253 - Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
20070135044 - Distributed underwater electromagnetic communication system
20070135509 - Indolone compounds useful to treat cognitive impairment
20070135510 - Indolone compounds useful to treat cognitive impairment
20070128192 - Human antibody molecules for il-13
20070128259 - Al-2 neurotrophic factor
20070128636 - Predictors of patient response to treatment with egfr inhibitors
20070129650 - Method and apparatus for fluid injection
20070129794 - Method and apparatus for prosthesis attachment using discrete elements

May 2007 - Heller Ehrman LLP patents

20070119259 - High sensitivity, low noise piezoelectric flexural sensing structure
20070121420 - Page access circuit of semiconductor memory device
20070122492 - Plant extracts and dermatological uses thereof
20070123802 - Methods and apparatus for an analyte detecting device
20070102010 - Naso-pharyngeal tissue engineering
20070104720 - Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
20070105102 - Method for detection and characterization of pre-malignant transformation
20070105191 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20070106973 - Diffused aerial image model semiconductor device fabrication
20070097727 - Nonvolatile ferroelectric perpendicular electrode cell, feram having the cell and method for manufacturing the cell
20070098729 - Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
20070100255 - Method and apparatus for body fluid sampling and analyte sensing

April 2007 - Heller Ehrman LLP patents

20070092505 - Production of humanized antibodies in transgenic animals
20070092513 - Erbb4 antagonists
20070092881 - Gene markers of tumor metastasis
20070092941 - Pro1298 polypeptides
20070093532 - Benzimidazole carboxamides as raf kinase inhibitors
20070087007 - Compounds, compositions and methods for the treatment of diseases characterized by a-33 related antigens
20070087322 - Method of preserving early embryos of experimental animals by vitrification
20070088151 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20070083668 - Method and apparatus for facilitating network expansion
20070076493 - Circuit for generating data strobe signal of semiconductor memory device
20070077544 - Life-like anatomic feature for testing injection of soft tissue fillers
20070077623 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20070078102 - Nf-kb oligonucleotide decoy molecules
20070078435 - Tissue augmentation methods using a medical injection apparatus

March 2007 - Heller Ehrman LLP patents

20070048219 - Antibody fragment-polymer conjugates and uses of same
20070048865 - Method for acceleration of stem cell differentiation

February 2007 - Heller Ehrman LLP patents

20070041144 - Method for reducing substrate noise from penetrating noise sensitive circuits
20070041964 - Wisp polypeptides and nucleic acids encoding same
20070043305 - Method and apparatus for penetrating tissue
20070043386 - Tissue penetration device
20070043860 - Virtual systems management
20070036794 - Agonist anti-trk-c monoclonal antibodies
20070038235 - Method and apparatus for penetrating tissue
20070038949 - Copyholder graphical user interface
20070031405 - Use of a33 antigens and jam-it
20070031414 - Dr5 antibodies and uses thereof
20070031434 - Uses for eph receptor antagonists and agonists
20070032812 - Method and apparatus for a tissue penetrating device user interface
20070033661 - Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin
20070023050 - Tracheostomy tube connector
20070024834 - Apparatus and process for determination of dynamic scan field curvature
20070026451 - Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
20070026487 - Secreted and transmembrane polypeptides and nucleic acids encoding the same

January 2007 - Heller Ehrman LLP patents

20070018757 - Systems and methods for blocking microwave propagation in parallel plate structures utilizing cluster vias
20070020261 - Combination therapy of her expressing tumors
20070020698 - Igf binding proteins
20070020709 - Igf binding proteins
20070014709 - Recovering metals from sulfidic materials
20070015407 - Mechanical spring component for use in memory device
20070016287 - Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
20070010474 - Nf-kappab oligonucleotide decoy molecules
20070010910 - Random access and random load dispensing unit
20070011753 - Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
20070003584 - Liquid crystal polymer syringes and containers and methods of use for long term storage of filler materials

December 2006 - Heller Ehrman LLP patents

20060292114 - Neurturin receptor
20060293329 - Substituted enaminones, their derivatives and uses thereof
20060293507 - Crystallization of igf-1
20060293713 - Methods and systems for treating bph using electroporation
20060293725 - Methods and systems for treating fatty tissue sites using electroporation
20060293730 - Methods and systems for treating restenosis sites using electroporation
20060293731 - Methods and systems for treating tumors using electroporation
20060286565 - Prediction of likelihood of cancer recurrence
20060286931 - Underwater communications system and method
20060287235 - Crystallization of igf-1
20060287510 - Crystallization of igf-1
20060281905 - Crystallization of igf-1
20060282441 - Definition and management of procedures in a distributed environment
20060272976 - Container for use in a random access and random load dispensing unit
20060275305 - Herceptin adjuvant therapy
20060275864 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20060276380 - Antimicrobial peptide, compositions, and uses therefor
20060276397 - Crystallization of igf-1
20060276724 - Method and apparatus for a point of care device

November 2006 - Heller Ehrman LLP patents

20060266034 - Direct compression wind energy system and applications of use
20060266035 - Wind energy system with intercooling, refrigeration and heating
20060266036 - Wind generating system with off-shore direct compression windmill station and methods of use
20060266037 - Direct compression wind energy system and applications of use
20060269554 - Dr5 antibodies and uses thereof
20060270838 - Pantropic neurotrophic factors
20060270839 - Crystallization of igf-1
20060271081 - Apparatus and methods for valve repair
20060271083 - Method and apparatus for penetrating tissue
20060260311 - Wind generating and storage system with a windmill station that has a pneumatic motor and its methods of use
20060260312 - Method of creating liquid air products with direct compression wind turbine stations
20060260313 - Direct compression wind energy system and applications of use
20060254045 - Flanged inner conductor coaxial resonators
20060256599 - Database of electronically profiled cells and methods for generating and using same
20060257897 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20060248864 - Apparatus for cleaning a diesel particulate filter with multiple filtration stages
20060248892 - Direct compression wind energy system and applications of use
20060246461 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20060246465 - Secreted and transmembrane polypeptides and nucleic acids encoding the same
20060246527 - Method and system for stabilization of arachidonic acid for use in platelet function assay
20060246528 - Method and system for absolute platelet percent aggregation determination
20060247209 - N-halogenated amino acids, n,n-dihalogenated amino acids and derivatives; compositions and methods of using them
20060247252 - Augmented cognitive training

October 2006 - Heller Ehrman LLP patents

20060240522 - Process for bacterial production of polypeptides
20060241666 - Method and apparatus for body fluid sampling and analyte sensing
20060241667 - Tissue penetration device
20060241748 - Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
20060233216 - Method and device for contactless temperature monitoring and temperature adjustment
20060233803 - Use of a33 antigens and jam-it
20060233804 - Igf antagonist peptides
20060234226 - Non-affinity purification of proteins
20060235083 - Peg-poly(ortho ester) graft copolymers and pharmaceutical compositions
20060235084 - Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions
20060235161 - Peg-polyacetal and peg-polyacetal-poe graft copolymers and pharmaceutical compositions
20060236395 - System and method for conducting surveillance on a distributed network
20060226364 - Method and system for enhanced radiation detection
20060228426 - Plant extracts for treatment of angiogenesis and metastasis
20060222658 - Vaccinia virus nucleic acids, polypeptides and immunogenic compositions
20060224329 - Protein arrays and methods and systems for producing the same

September 2006 - Heller Ehrman LLP patents

20060209276 - Method and apparatus for self-referenced wafer stage positional error mapping
20060209410 - Method and apparatus for compensation or amelioration of lens field curvature and other imaging defects by utilizing a multi-wavelength setting illumination source
20060212414 - Artificial intelligence system for genetic analysis
20060212956 - Animal model of ligand activated her2 expressing tumors
20060202784 - Systems and methods for blocking microwave propagation in parallel plate structures
20060204399 - Method and apparatus using optical techniques to measure analyte levels
20060204505 - Methods for identifying tumors responsive to treatment with her dimerization inhibitors (hdis)
20060205662 - Combination treatment with t-pa variant and low molecular weight heparin
20060199365 - Junction-isolated vias
20060200044 - Method and apparatus for measuring analytes



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