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Harry FINCH patents

Recent bibliographic sampling of Harry FINCH patents listed/published in the public domain by the USPTO (USPTO Patent Application #,Title):



08/29/13 - 20130225617 - Indoles and their therapeutic use
Compounds of the invention are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions....
Inventors: George Hynd, John Gary Montana, Harry Finch, Rosa Arienzo, Barbara Avitabile-woo, Mathias Domostoj (Pulmagen Therapeutics (asthma) Limited)

11/01/12 - 20120277275 - Azole and thiazole derivatives and their use
Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiratory tract diseases:...
Inventors: Nicholas Charles Ray, Richard James Bull, Harry Finch, Marco Van Den Heuvel, Jose Antonio Bravo (Pulmagen Therapeutics (synergy) Limited)

08/09/12 - 20120202826 - Tetrahydropyrrolopyrimidinediones and their use in therapy
Including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part....
Inventors: Nicholas Charles Ray, Harry Finch, Christine Edwards, Elizabeth O'connor

07/19/12 - 20120184579 - Quinolines and their therapeutic use
Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms;...
Inventors: John Gary Montana, Harry Finch, George Hynd, Michael Colin Cramp, Rosa Arienzo, Neville Mclean

02/16/12 - 20120041043 - Sulfonamide compounds for the treatment of respiratory disorders
Compounds of formula (I) are agonists of PPARγ, useful for the treatment of respiratory disease; formula (I): wherein R1, R2 or R3 each independently represents halo, cyano, nitro, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, carboxylic acid or an ester or amide thereof; R4 represents hydrogen or alkyl; m, n or p...
Inventors: Vidya Ramdas, Harry Finch, Craig Fox (Dr. Reddy's Laboratories Ltd)

03/24/11 - 20110071175 - Indoles and their therapeutic use
Compound of formula (I) are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. Wherein X is —SO2— or *—SO2NR3— wherein the bond marked with an asterisk is attached to Ar1; R1 is hydrogen, fluoro, chloro, CN or CF3; R2 is hydrogen, fluoro or chloro; R3...
Inventors: George Hynd, John Gary Montana, Harry Finch, Rosa Arienzo, Barbara A. Vitabile-woo, Mathias Domostoj

03/10/11 - 20110060026 - Indoles active on crth2 receptor
Indole derivatives having therapeutic utility are of formula (I): X is —SO2— or *—SO2NR3— wherein the bond marked with an asterisk is attached to Ar1; R1 and R2 are, independently, hydrogen, fluoro, chloro, CN or CF3; R3 is hydrogen, C1-C8alkyl or C3-C7cycloalkyl; and Ar1 and Ar2 are, independently, phenyl or...
Inventors: George Hynd, John Gary Montana, Harry Finch

03/03/11 - 20110053986 - Respiratory disease treatment
There is provided a pharmaceutical composition that is adapted for pulmonary administration by inhalation, which composition comprises a glitazone, such as pioglitazone or rosiglitazone, and one or more pharmaceutically acceptable carriers and/or excipients, and wherein the glitazone content of the composition consists of at least 95% by weight of the...
Inventors: Harry Finch, Craig Fox, Mohammed Sajad, Monique Bodil Van Niel, Andrew Forrest

06/10/10 - 20100144852 - Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses
Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula (I) wherein A is an oxygen atom or group —N(R12)—; (i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group —R5, —Z—Y—R5—Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H; and R3 is a lone pair,...
Inventors: Harry Finch, Nicholas Charles Ray, Richard James Bull, Monique Bodil Van Niel, Andrew Stephen Robert Jennings (Argenta Discovery Limited)

06/10/10 - 20100144787 - Quinolines and their therapeutic use
Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms;...
Inventors: John Gary Montana, Harry Finch, George Hynd, Michael Colin Cramp, Rosa Arienzo, Neville Mclean

06/10/10 - 20100144786 - Quinoline derivatives as crth2 receptor ligands
Specific quinoline derivatives are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component....
Inventors: Michael Colin Cramp, Rosa Arienzo, George Hynd, Peter Crackett, Yann Griffon, Trevor Keith Harrison, Nicholas Charles Ray, Harry Finch, John Gary Montana

06/03/10 - 20100137300 - Indolizine acetic acid derivatives as crth2 antagonists
The specific compounds of this list: {7-cyano-2-methyl-1-[4-(morpholine-4-sutfonyl)benzyl]indolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylbenzyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro4-(morpholine-4-sulfonyl)benzyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro-4-(morpholine-4-sutfonyl)phenylsutfanyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {7-cyano-1-(6-fluoroquinolin-2-ylmethyl)-2-methylindolizin-3-yl}acetic acid are ligands of the CRTH2 receptor and are useful in the treatment of respiratory diseases....
Inventors: George Hynd, Nicholas Charles Ray, Harry Finch, John Gary Montana, Michael Colin Cramp, Trevor Keith Harrison, Rosa Arienzo, Paul Blaney, Yann Griffon, David Middlemiss

05/06/10 - 20100113540 - Azole and thiazole derivatives and their use
Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiratory tract diseases: wherein (i) R1 is C1-C6-alkyl or hydrogen; and R2 is hydrogen or a group —R7, —Z—Y—R7, —Z—NR9R10; —Z—CO—NR9R10, —Z—NR9—[AE11]C(O)O—R7, or —Z—C(O)—R7; and R3 is a lone pair,...
Inventors: Nicholas Charles Ray, Richard James Bull, Harry Finch, Marco Van Den Heuvel, Jose Antonio Bravo (Argenta Discovery Limited)

04/15/10 - 20100093751 - Indolizineacetic acids and their therapeutic use as ligands of the crth2 receptor
Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, inter alia, respiratory diseases: wherein R1 is fluoro, chloro, cyano or trifluoromethyl; R2 is hydrogen, fluoro or chloro; R3 is hydrogen, fluoro, chloro or trifluoromethyl; X is —CH2—, —S—, —S(═O)— or —S(═O)2—; one of Y and Y1 is...
Inventors: George Hynd, John Gary Montana, Harry Finch, Trevor Harrison, Janusz Kulagowski

03/04/10 - 20100056565 - Heterocyclic derivatives as m3 muscarinic receptors
This invention relates to M3 antagonists of formula (I) wherein R2, R4, R5, R6, W, V, A, D, X, t, u and v are as defined herein; pharmaceutical compositions containing them; methods for their preparation; and their use in the treatment of diseases where enhanced M3 receptor activation is implicated....
Inventors: Barbara Giuseppina Avitabile, Harry Finch, Jamie David Knight, Alan John Nadin, Nicholas Charles Ray (Argenta Discovery Limited)

01/14/10 - 20100010034 - Crth2 antagonists
The following compounds are CRTH2 antagonists, useful in treatment of respiratory disease: [3-(2,4-dichlorophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(2-fluoro-4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methanesulfonyl-2-trifluoromethylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, (R)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, [3-(4-ethanesulfonylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, (S)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, ethanesulfonylaminobenzenesulfonyl)-6-fluoro-2-methyiindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(2-chloro-4-methanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(4-methanesulfonylbenzyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-chlorobenzyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(6-fluoroquinolin-2-yl-methyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-bromophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, and [3-(4-cyclopropylsulfamoylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid....
Inventors: George Hynd, Nicholas Charles Ray, Harry Finch, David Middlemiss, Michael Colin Cramp, Paul Matthew Blaney, Karen Williams, Yann Griffon, Trevor Keith Harrison, Peter Crackett

06/25/09 - 20090163534 - Indolizine derivatives
Compounds of formula (I) are ligands of the CRTH2 receptor and are useful in the treatment of respiratory disease: Formula (I) wherein R1, R2, R3 and R4 each independently are hydrogen, C1C6alkyl, fully or partially fluorinated C1C6alkyl, halo, —S(O)nR10, —SO2N(R10)2, —N(R10)2, —C(O)N(R10)2, —NR10C(O)R9, —CO2R10, —C(O)R9, —NO2, —CN or —OR11; wherein...
Inventors: George Hynd, Nicholas Charles Ray, Harry Finch, David Middlemiss, Michael Colin Cramp, Paul Matthew Blaney, Karen Williams, Yan Griffon, Trevor Keith Harrison, Peter Crackett

06/18/09 - 20090156600 - Quinolines and their therapeutic use
Compounds of formula [1] are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component; in which: R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6alkyl, C1-C6-fluoroalkyl, cyclopropyl, halo, —S(O)nR6, —SO2NR7R8, —NR7R8, —NR7C(O)R6, —CO2R7, —C(O)NR7R8, —C(O)R76, —NO2, —CN or a group —OR9; wherein each R6 is independently...
Inventors: Michael Colin Cramp, Rosa Arienzo, George Hynd, Peter Crackett, Yann Griffon, Trevor Keith Harrison, Nicholas Charles Ray, Harry Finch, John Gary Montana

04/30/09 - 20090111795 - Multimers of heterocyclic compounds and their use
A compound of formula (I): M-L-M, wherein L is a linker and each M is independently a group of formula (II): is useful in therapy, e.g. of respiratory diseases....
Inventors: Harry Finch, Christine Edwards, Nicholas Charles Ray, Anne O'connor, Mary F. Fitzgerald

04/23/09 - 20090105268 - Dihydropyrimidone multimers and their use as human neutrophil, elastase inhibitors
A compound of formula M-L-M (I) wherein L is a linker and each M is independently a group of formula (II) is useful in therapy, e.g. of respiratory diseases....
Inventors: Harry Finch, Christine Edwards, Nicholas Charles Ray, Mary Frances Fitzgerald

04/09/09 - 20090093477 - Tetrahydropyrrolopyrimidinediones and their use in therapy
—[X]m-[Alk1]p-[Q]n-[Alk2]q-[X1]k-Z wherein k, m, n, p and q are independently 0 or 1; Alk1 and Alk2 each independently represent an optionally substituted C1-C6 alkylene, or C2-C6 alkenylene radical which may optionally contain an ether (O—), thioether (—S—) or amino (—NRA—) link wherein RA is hydrogen or C1-C3 alkyl; Q represents...
Inventors: Nicholas Charles Ray, Harry Finch, Christine Edwards, Elizabeth O'connor

Pulmagen Therapeutics (asthma) Limited, Pulmagen Therapeutics (synergy) Limited, Dr. Reddy's Laboratories Ltd, Argenta Discovery Limited

Archived*
(*May have duplicates - we are upgrading our archive.)

20090093477 - Tetrahydropyrrolopyrimidinediones and their use in therapy


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The bibliographic references displayed about Harry FINCH's patents are for a recent sample of Harry FINCH's publicly published patent applications. The inventor/author may have additional bibliographic citations listed at the USPTO.gov. FreshPatents.com is not associated or affiliated in any way with the author/inventor or the United States Patent/Trademark Office but is providing this non-comprehensive sample listing for educational and research purposes using public bibliographic data published and disseminated from the United States Patent/Trademark Office public datafeed. This information is also available for free on the USPTO.gov website. If Harry FINCH filed recent patent applications under another name, spelling or location then those applications could be listed on an alternate page. If no bibliographic references are listed here, it is possible there are no recent filings or there is a technical issue with the listing--in that case, we recommend doing a search on the USPTO.gov website.

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