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Glycopeptide antibioticsRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai, CyclopeptidesGlycopeptide antibiotics description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20050288221, Glycopeptide antibiotics. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority from copending provisional application Ser. No. 60/286,396 filed on Apr. 25, 2001, copending provisional application Ser. No. 60/286,249 filed on Apr. 25, 2001 and copending provisional application Ser. No. 60/286,244 filed on Apr. 25, 2001 all incorporated herein by reference. FIELD OF THE INVENTION [0002] The present invention relates to novel glycopeptides, which are,useful as antibiotics. BACKGROUND OF THE INVENTION [0003] New improved antibiotics are continually in demand, for the treatment of human diseases. Antibiotic resistant organisms are continually a problem, particularly in hospitals. Vancomycin has been the last defense. However, especially in hospitals, isolates which are vancomycin resistant are becoming more common. A recent survey found 7.9% of Enterococci in United States hospitals are now vancomycin resistant. "Nosocomial Enterococci Resistant to Vancomycin" Morbidity and Mortality Weekly Report 42(30):597-598(1993). Further resistance of Vancomycin and other antibiotics to Enterococcus faecium is reported, Handwergers. et al., Clin. Infect. Dis. 1993(16),750-755. Additional resistance to enterococci is reported, Boyle, J F, Clin. Microbiol. 1993(31),1280-1285. Vancomycin resistance has been reported against Staphylococcus aureus, F. A. Waldvogel, The New England Journal of Medicine, 340(7), 1999. Additional reports include: Murry, B. E. The New England Journal of Medicine, 342(10), 710-721(2000) and Y. Cetinkaya et al, Clinical Microbiology Reviews, 13(4) 686-707(2000). Clearly, antibiotic resistance is a growing public health problem. Having new antibiotics available could provide additional options for physicians in treatment regimens. [0004] The search for new antibiotics which exhibit improved antibacterial activity against vancomycin-resistant isolates and having structures which are not derivatives of vancomycin are particularly appealing targets for screening and synthetic efforts. Structural similarity to existing antibiotics could facilitate the emergence of resistance. [0005] The AC98-antibiotic complex isolated as an unseparated mixture of compounds of undetermined structure produced from cultures of Streptomyces hygroscopicus (strain NRRL 3085) is described in U.S. Pat. No. 3,495,004. It is an object of this invention to provide a novel family of glycopeptide antibiotics which are shown to possess antibacterial activity, especially against vancomycin resistant bacterial isolates and in particular having chemical structures unlike vancomycin. SUMMARY OF THE INVENTION [0006] This invention is concerned with novel glycopeptides which have antibacterial activity; with methods of treating infectious disease in mammals employing these novel glycopeptides; with pharmaceutical preparations containing these glycopeptides and processes for the production of glycopeptides of the invention. More particularly, this invention is concerned with glycopeptides which have enhanced antibacterial activity against vancomycin, penicillin and methicillin resistant strains. Compounds according to the invention comprise compounds of the formula: 2 [0007] wherein: [0008] R.sup.1 is a moiety selected from: 3 [0009] R.sup.1a is H or halogen; [0010] R.sup.2 is a moiety selected from: 4 [0011] provided when R.sup.2 is selected from the moieties: 5 [0012] that R.sup.1 is selected from the moieties: 6 [0013] R.sup.2a is selected from H, alkyl(C.sub.1-C.sub.20), cycloalkyl(C.sub.3-C.sub.20), alkenyl(C.sub.3-C.sub.20), alkynyl(C.sub.3-C.sub.20), the group --C(O)--Y-Z, and a moiety selected from: 7 [0014] Y is selected from a single bond, --O-- and --NR.sup.8a--; [0015] Z is selected from alkyl(C.sub.1-C.sub.20), cycloalkyl(C.sub.3-C.su- b.20), alkenyl(C.sub.3-C.sub.20), alkynyl(C.sub.3-C.sub.20), aryl and heteroaryl; [0016] and when Y is a single bond then Z is also selected from H, alkenyl(C.sub.2-C.sub.20) and alkynyl (C.sub.2-C.sub.20); [0017] R.sup.2b and R.sup.2c are independently selected from H, halogen, alkyl(C.sub.1-C.sub.20), cycloalkyl(C.sub.3-C.sub.20), alkenyl(C.sub.2-C.sub.20), alkynyl(C.sub.2-C.sub.20), aryl, heteroaryl, --NH.sub.2, --NR.sup.2fR.sup.2g, and --NO.sub.2, provided when R.sup.2b is --NO.sub.2, that R.sup.2c must be H; [0018] R.sup.2d is selected from alkyl (C.sub.1-C.sub.20), alkenyl(C.sub.2-C.sub.20), alkynyl(C.sub.2-C.sub.20), aryl, heteroaryl, and when R.sup.2 is 8 [0019] R.sup.2d may also be the group L-M, wherein; [0020] L is selected from --NH--, --S--, --SCH.sub.2C(O)--, and a group of the formula: 9 Continue reading about Glycopeptide antibiotics... Full patent description for Glycopeptide antibiotics Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Glycopeptide antibiotics patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Glycopeptide antibiotics or other areas of interest. ### Previous Patent Application: Osteoprotegerin in milk Next Patent Application: Methods for enhancing the bioavailability of a drug Industry Class: Drug, bio-affecting and body treating compositions ### FreshPatents.com Support Thank you for viewing the Glycopeptide antibiotics patent info. 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