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Enzyme delivery systems, application in water based productsRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Live Hair Or Scalp Treating Compositions (nontherapeutic), Polymer Containing (nonsurfactant, Natural Or Synthetic), Protein Or DerivativeEnzyme delivery systems, application in water based products description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070148119, Enzyme delivery systems, application in water based products. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS REFERENCE OF PRIORITY APPLICATION [0001] This application claims the benefit of U.S. Provisional Application No. 60/536,309, filed Jan. 13, 2004, which is hereby incorporated by reference in its entirety. DESCRIPTION [0002] The present invention refers to stabile aqueous and non-aqueous enzyme delivery systems suitable as additives for cosmetics and personal care products, and to stabile aqueous cosmetics and personal care products comprising an effective amount of at least one enzyme, and to the use of enzymes in recreational water applications. [0003] Cosmetics and personal care products are known to contain various enzymes, for example proteases, lipases or oxidases Proteases are capable of exfoliating cells from the skin, and thus can be used to renew and moisturize the skin and to reverse the outward signs of aging of the skin. Lipases can be used to treat excessive oiliness of the skin or hair, and oxidases can be used to destroy melanin, thereby resulting in lightening of the skin or bleaching of hair. [0004] Many enzymes quickly lose their activity in aqueous systems. Therefore it is necessary to stabilize enzymes in aqueous cosmetics or personal care products. [0005] Various attempts have been made to stabilize enzymes, especially proteases, in aqueous cosmetic compositions. [0006] U.S. Pat. No. 5,830,449 A describes a cosmetic composition used for cleansing and/or protecting the skin. The composition comprises at least one enzyme, for example a protease, a lipase or a lactoperoxidase, and a stabilizing system consisting of at least one polyol and at least one acrylic or methacrylic polymer. The polyols can be glycerol or a glycol such as propylene glycol or polyethylene glycol. [0007] U.S. Pat. No. 5,935,559 A describes a cosmetic composition used for cleansing the skin or to combat drying, ageing or pigmentation of the skin. It comprises a combination of silicone oil and a polyol as the stabilizing system for maintaining the activity of water sensitive agents such as enzymes, for example proteases. The polyol can be glycerol or a glycol such as propylene or ethylene glycol. [0008] For the preparation of cosmetics and personal care products comprising an effective amount of at least one enzyme, it is more convenient to use aqueous or non-aqueous enzyme delivery systems which are solutions, emulsions or dispersions instead of enzyme powders. Such enzyme delivery systems are easier to handle and there is less risk of inhalation. [0009] The use of enzymes in recreational water applications has not been described so far. [0010] It is an object of the present invention to provide stabile aqueous enzyme delivery systems suitable for preparing aqueous cosmetics or personal care products. It is also an object of the present invention to provide stabile aqueous cosmetics or personal care products comprising an effective amount of at least one enzyme. [0011] It was found that polyglycerols containing at least 15 carbon atoms have an enhanced stabilizing effect on enzymes in aqueous enzyme delivery systems compared to the stabilizing effect of glycerol. [0012] The aqueous enzyme delivery system of the present invention comprises at least one enzyme and a polyglycerol containing at least 15 carbon atoms. [0013] The enzyme can be a hydrolase (EC 3), an oxidoreductase (EC 1) or a mixture comprising a hydrolase and/or oxidoreductase. Examples of hydrolases are lipases, esterases, amylases, cellulases and proteases. Examples of oxidoreductases are oxidases and peroxidases. [0014] Preferably, the enzyme is selected from the group consisting of proteases, lipases, esterases and oxidases. More preferably, the enzyme is a protease. Even more preferably, the enzyme is a cysteine proteinase. Most preferably, the enzyme is papain and/or bromelain. [0015] The concentration of the enzyme in the aqueous enzyme delivery system is adjusted to render it suitable as an additive for aqueous cosmetics and personal care products. For example, the concentration of papain in the aqueous delivery system can range from 100 to 10,000 PU/mg, the concentration of bromelain can range from 1 to 1,000 GDU/g, the concentration of glucose oxidase can range from 500 to 1,000 GO/g and the concentration of lipase can range from 100 to 10,000 LU/g. [0016] A proteolytic unit (PU) is defined as the quantity of enzyme which liberates one microgram of tyrosine per hour. A gelatin digestion unit (GDU) is defined as the quantity of enzyme which liberates 1 mg of amino nitrogen from standard gelatin at pH 4.5 or 5.5 after 20 minute. A lipase Unit (LU) is determined by hydrolysis of p-nitrophenyl butyrate to nitrophenol by the lipase and measuring the rate of absorbance at a given time and comparing it to a standard. A glucose oxidase titrimetric unit of activity (GO) is the quantity of enzyme that will oxidize 3 mg of glucose to gluconic acid in 50 minutes at 35.degree. C. [0017] A polyglycerol containing at least 15 carbon atoms can be a single compound or a mixture thereof. Examples of polyglycerols containing at least 15 carbon atoms are pentaglycerol, hexaglycerol, heptaglycerol, octaglycerol, nonaglycerol and decaglycerol. Preferably, the polyglycerol contains at least 21 carbon atoms, more preferably at least 27 carbon atoms, and even more preferably at least 30 carbon atoms. Most preferably the polyglycerol is decaglycerol. [0018] The aqueous enzyme delivery system can also comprise antimicrobial agents such as Geogard.RTM. 361 and Natrulon.RTM. PC-15. [0019] In one embodiment the aqueous enzyme delivery system additionally comprises a polyol. The polyol can be a monomeric polyol containing maximal 6 carbon atoms or a polymeric glycol. Examples of polyols containing maximal 6 carbon atoms are glycerol, ethylene glycol, propylene glycol, butylene glycol and sorbitol. Examples of polymeric glycols are polyethylene glycol 200 and 400. [0020] Preferably, the ratio of polyglycerol/polyol is at least 1:10 (weight/weight), more preferably the ratio of polyglycerol/ polyol is at least 1:1 (weight/weight). Most preferably the ratio is greater than 5:1 (weight/weight). [0021] The aqueous enzyme delivery system can be a solution, a water-in-oil emulsion or an oil-in-water emulsion. [0022] In a preferred embodiment the aqueous enzyme delivery system forms a solution. Preferably, the total content of polyglycerol and optional polyol in the aqueous enzyme delivery system which forms a solution is at least 40% by weight. More preferably it is at least 60% by weight. Most preferably, it is 80% by weight. Continue reading about Enzyme delivery systems, application in water based products... Full patent description for Enzyme delivery systems, application in water based products Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Enzyme delivery systems, application in water based products patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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