Drug, bio-affecting and body treating compositions inventions 04/06

20060088471 - Compounds for enzyme inhibition: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the...

20060088472 - E7 regulation of p21 cip1 through akt: Disclosed are compositions and methods for inhibiting E7 effects on Akt, such as preventing the nuclear localization of p21Cip1....

20060088473 - Treatment screening methods: The invention includes a method to identify a method to enhance survival of a subject such as a non-human primate that has been exposed to a biological insult such as an ionizing radiation dose of about LD30/30 or about LD50/30 by treating the exposed subject with a test compound an...

20060088474 - Endohedral metallofullerene contrast agents: An image contrast agent for creating an image of a portion of a body is disclosed. The contrast agent can provide contrast for two different types of imaging techniques, such as x-ray imaging and magnetic resonance imaging. The contrast agent includes an endohedral metallofullerene compound with an atom encapsulated in...

20060088475 - Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase: The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors....

20060088476 - Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium...

20060088478 - Apparatus and method for applying cosmetic and/or therapeutic formulations: An apparatus, a method for manufacturing the apparatus, and a method for dispensing a formulation to a person or animal using the apparatus, wherein the apparatus includes: a dispensing container; an amount of formulation contained in the container; and a propellant contained in the container, wherein the propellant comprises between...

20060088477 - Compositions and methods of dispensing palliative or therapeutic agents: The present invention is a palliative or therapeutic foam for medicating or treating affected biological tissue having a pH of 7.0 to 8.0 and including a hydrated dialkali monometal complex such as disodium monocopper(II) citrate dihydrate or disodium monozinc(II) citrate dihydrate and triethanolamine lauryl sulfate in a concentration of less...

20060088479 - Particle formulation and its preparation: Powder compositions are prepared which compose microparticles having a bioactive agent dispersed therein. The compositions are prepared by spray drying a solution or suspension of the bioactive and collecting the resulting microparticles using a separator....

20060088480 - Oral composition for stabilization, (re)calcification and (re)mineralization of tooth enamel and dentine: An oral composition for the stabilization, (re)calcification and (re)mineralization of dental enamel and dentin to create an efficient protection from tooth decay is based on the use of calcium form of zeolite, phosphate salts soluble in water and matrix proteins of teeth and the adjustment of pH in the mouth...

20060088482 - Oral and dental care agent: The invention relates to oral and dental care agents, containing: an active ingredient combination (A) of at least one cationic component with an anti-bacterial action, (B) at least one active ingredient with an anti-tartar action, selected from the group of azacycloalkane diphosphonic acids or their phnysiologically compatible salts and (C)...

20060088481 - Topical oral dosage forms containing bismuth compounds: Topical oral dosage forms containing bismuth compounds are described, which are useful for treating H. pylori and other bacterial infections that cause gastrointestinal disorders and halitosis, as well as for treating ocular and dermal wounds. Methods of employing topical oral dosage forms for treating bacterial infections that cause gastrointestinal disorders...

20060088483 - Kit and method of applying makeup: The present invention relates to a kit for applying makeup to a surface such as the skin, the nails, hair, or the lips, said kit comprising: a first cosmetic composition including magnetic particles that are movable under the effect of a magnetic field; a second cosmetic composition for covering or...

20060088484 - Method of applying makeup to a surface and a kit for implementing such a method: The present invention relates to a method of applying makeup to a surface, such as the skin, the nails, hair, or the lips, said method comprising the following steps: depositing at least a first cosmetic composition in the fluid state on the surface, said composition containing magnetic particles that are...

20060088485 - Melanogenesis inhibitor and skin preparation containing the same: wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a...

20060088486 - Topical use of post-application expanding cosmetic composition: The present invention provides a method for imparting to the lips the appearance of more fullness and to the skin, particularly the face, the masking of surface irregularities, such as fine lines, wrinkles, and blemishes, by applying thereto a post-application expanding composition. The composition comprises one or more surfactants, a...

20060088487 - Block ethylenic copolymers comprising a vinyllactam block, cosmetic or pharmaceutical compositions containing them and cosmetic use of these copolymers: and from 1% to 48% by weight of at least one ionic hydrophilic monomer; and at least one block B obtained from monomers not comprising an ethylenic monomer comprising a lactam ring of formula (I), or comprising a minor proportion thereof; a cosmetic or pharmaceutical composition, such as a hair...

20060088488 - Dyeing composition comprising a mixture of at least one pigment and at least one electrophilic monomer: Disclosed is a dyeing keratin materials comprising applying to said materials at least one composition comprising, in a suitable dyeing medium, at least one electrophilic monomer, at least one colored pigment and at least one pigment that has a refractive index greater than the at least one colored pigment....

20060088489 - Sustained release of active molecules from polymers topically applied to skin or hair: The invention relates to a polymer for topical delivery of biologically active ingredients, the polymer comprising at least one moiety: U-B-A in which U represents a physiologically acceptable unit of an oligomer or polymer, A represents a biologically active component, and B represents one or more bond(s) linking A to...

20060088490 - Method for treating hair: The present invention provides a treating method having a good continuity of the reform effects of the hair, and which is also excellent in safety. In the method, a hair inside repair agent including at least water and a component to repair an inside of the hair is applied as...

20060088493 - Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers: The present patent application relates to a process for the cosmetic treatment of keratin materials, including keratin fibers such as the hair. The process comprises applying the composition to the keratin materials, wherein the composition comprises, in a cosmetically acceptable medium, at least one electrophilic monomer and at least one...

20060088492 - Hair treatment agents: The invention relates to cosmetic agents for treating, particularly for caring for, human hair. These agents contain an active combination consisting of: (A) at least one water-insoluble volatile silicone; (B) at least one cationic polymer, and; (C) at least one additional hair care substance selected from the group consisting of...

20060088491 - Novel polyol-glycoside compositions for the skin: The invention concerns novel polyol-glycoside compositions for topical use. The invention is characterized in that said compositions contain an efficient amount of polyol-glycoside obtained by acetalization of a polyol of formula (I), wherein n is an integer equal to 2, 3 or 4; or of formula (II), wherein m is...

20060088494 - Method of treating hair with form memory polymers: A method for the provision of a recallable hair transformation using shape-memory polymers is disclosed. In this respect a composition which comprises a macromer or prepolymer which is cross-linkable to a shape-memory polymer is applied onto the hair and the hair is brought into a defined (permanent) shape and subsequently...

20060088496 - Personal care compositions with salts of hydroxypropyl trialkylammonium substituted mono-saccharide: A personal care composition is provided which includes a quaternary ammonium compound which is a salt of hydroxypropyl tri(C1-C3 alkyl) ammonium mono-substituted mono-saccharide. Particularly preferred are hydroxypropyl trimonium quaternized glucose or fructose. These quaternary ammonium salts provide moisturization properties to the personal care composition both in high and low relative...

20060088495 - Personal care products which include dihydroxypropyltri(c1-c3 alkyl) ammonium salts: A personal care product is provided which includes a composition containing dihydroxypropyltri(C1-C3 alkyl) ammonium salt in a carrier. The composition is packaged for delivery to a consumer and includes instructions printed on or associated with the packaging indicating topical use of the composition on skin, hair or the oral mucosae....

20060088497 - Topical skin care composition: A topical skin care product formula having a beneficial effect on the user's face and/or neck skin and appearance. The formula can be used for preparation of a skin cream and/or skin serum to be rubbed into the skin and/or a liquid to be applied to a pad and placed...

20060088498 - Anti-microbial composition using in-situ generation of an oxidizing agent: A composition for providing an antimicrobial oxidizing agent is presented. The composition includes a core containing a reactant, and a reactor wall forming a reactor space that contains the core. The reactant generates an antimicrobial oxidizer product through a chemical reaction when contacted by a main solvent. The reactor wall...

20060088499 - Amphiphilic dendritic dipeptides & their self-assembly into helical pores: An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other applications....

20060088500 - Animal lure candle: A candle is formed from a heated mixture of liquid wax, an animal attracting scent, and a scent retention additive. A wire core wick imbedded in the candle mixture is lighted to give off the animal attracting scent into the air. A container shields the candle from the wind, but...

20060088501 - Duffy antigen receptor for chemokines and use thereof: The invention relates to Duffy antigen receptor for chemokines and uses thereof. In one embodiment, the invention provides a method for screening for drug candidates that inhibit angiogenesis. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds to the Duffy...

20060088502 - Drug for reducing side effects in ribavirin interferon combination therapy: There is provided a drug for reducing side effects, anemia in particular, in combination therapy of chronic hepatitis C with ribavirin and interferon, which contains as the active ingredient at least one member selected from the group consisting of eicosapentaenoic acid (EPA) and pharmaceutically acceptable salts and esters thereof....

20060088503 - Cellular and genetic intervention to treat ventricular tachycardia: A method for decreasing risk of ventricular tachycardia following myocardial infarction increases cell-to-cell coupling and/or excitability in the border zone of an infarcted region of myocardial tissue. Enhanced conduction to treat the border zone is carried out by genetically modifying myocytes in the border zone to form more gap junctions...

20060088504 - Compositions and methods for effecting the levels of high density lipoprotein (hdl) cholesterol and apolipoprotein al, very low density lipoprotein (vldl) cholesterol and low density lipoprotein (ldl) cholesterol: Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a...

20060088511 - Cancer therapy sensitizer: The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of...

20060088512 - Treatment of t cell disorders: The present invention relates to a method for treating a T cell disorder in a subject involving disrupting sex steroid signaling to the thymus and introducing into the subject bone marrow or haemopoietic stem cells (HSC)....

20060088513 - Antiallergic composition: As for means for solving the object, it is to provide an antiallergic composition comprising as active ingredients the lactic acid bacteria showing equal interleukin 12 production level compared to when Lactobacillus paracasei KW 3110 strain is used as the lactic acid bacteria to be tested, or showing 60% or...

20060088514 - Formulation comprising a bacterial strain: An injectable formulation of a bacterial strain such as a Lactobacillus salivarius strain is useful in treating of inflammatory disorders such as colitis or arthritis....

20060088505 - Hair follicle mesenchymal stem cells and use thereof: The present invention relates to a method for isolating hair follicle mesenchymal stem cells and to the use thereof for therapy and prophylaxis as well as for cosmetic treatments....

20060088509 - Isolated clk-1 -/- cells from clk-1 heterozygous animals and their use in treating oxidative stress disorders: The invention relates to the field of oxidative stress disorder and more specifically to isolated cells from clk-1 +/− animals that do not express CLK1. The invention also relates to methods for treating a subject or a diseased tissue in need of treatment for oxidative stress disorder using isolated clk-1...

20060088508 - Method for obtaining characterized muscle-derived cell populations and uses: A method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products includes culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of...

20060088506 - Process for producing cartilage cells for transplantation: This invention is intended to provide a method to quickly obtain a large amount of normal human chondrocytes or a mass thereof without fear of bacterial or viral infection. Namely, a method of producing human chondrocytes characterized by comprising co-culturing chondrocytes obtained from a cartilage having perichondrium, for example, auricular...

20060088507 - Rhodamine derivatives for photodynamic diagnosis and treatment: The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of...

20060088510 - Targeted delivery of biological factors using self-assembling peptide nanofibers: The present invention is directed to methodology that allows a variety of compounds to be attached to self-assembling peptides using biotin/streptavidin linkages. The peptides can be used to form a biologically compatible membrane that promotes the growth and differentiation of cells. The attached therapeutic agents can be used to promote...

20060088515 - Methods and devices for sustained in-vivo release of an active agent: The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the...

20060088516 - Synthetic peptide combinations and methods of producing same: Preparation containing synthetic peptide combinations for application to humans or animals, wherein the peptide combinations originate from the partial hydrolysis of tissues from the human organism, wherein the peptide combinations are obtained from the neosynthesis of peptides, with the latter corresponding in their structure and composition to the tissue of...

20060088517 - Compounds and methods for treating seizure disorders: This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells....

20060088519 - Malignant tumor-inhibiting preparation comprising des a fibrin: A malignant tumor-inhibiting preparation is provided which comprises Des A fibrin and therefore can inhibit the spreading and migration of malignant tumor cells and thereby can inhibit the malignant tumors....

20060088518 - Stable thrombin composition: The stable thrombin composition comprises purified thrombin, human albumin and a neutral salt, the resulting product being stable when stored as a lyophilisate or frozen and is adjusted to a nominal strength of 500 IU of thrombin or more per ml of solution, the human albumin being in a concentration...

20060088523 - Antibody formulations: The present application describes antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation comprising an antibody that binds to domain II of HER2 (for example, Pertuzumab), and a formulation comprising an antibody that binds to DR5 (for example, Apomab)....

20060088520 - Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their production or generation: The invention relates to a conjugate for targeting antigen presenting cells comprising: at least one antigenic moiety conjugated to a targeting moiety that is capable of binding to a cell surface structure of an antigen presenting cell, wherein the conjugate is capable of being internalized and processed by said antigen...

20060088521 - Composition and method for cancer treatment: Anti-CEACAM6 antibodies and antibody fragments, nucleic acids encoding them, methods of their manufacture, and methods to treat cancer using these compounds are provided....

20060088527 - Compositions and methods for the therapy and diagnosis of lung cancer: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides....

20060088522 - Humanized anti-5t4 antibodies and anti-5t4/calicheamicin conjugates: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same....

20060088526 - Humanized anti-cd3 specific antibodies: Novel aglycosylated antibodies having a binding affinity for the CD3 antigen complex are of value for use in therapy, particularly in immunosuppression....

20060088525 - Therapeutic binding molecules: A molecule comprising at least one antigen binding site, comprising in sequence the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence Asn-Tyr-Ile-Ile-His (NYIIH), said CDR2 having the amino acid sequence Tyr-Phe-Asn-Pro-Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe-Lys-Gly (YFNPYNHGTKYNEKFKG) and said CDR3 having the amino acid sequence Ser-Gly-Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT); e.g. further comprising...

20060088524 - Tissue factor compositions and methods: Tissue Factor (natural or recombinant truncated) can be incorporated into stable, soluble nanoscale particles so that activity is maintained. These particles can be used as a reagent in prothrombin clotting time assays or they can be used in therapeutic compositions for use in humans or animals. Therapeutic settings can include...

20060088529 - Bispecific monoclonal antibodies to il-12 and il-18: A bispecific monoclonal antibody is described which comprises two moieties, one of which comprises an antigen-binding region which is specific for either the IL-12Rβ1 or the IL-12Rβ2 subunit of an IL-12 receptor, and the other of which comprises an antigen-binding region which is specific for either the IL-18R or the...

20060088528 - Methods and compositions for treating alzheimer's disease: The present invention relates to the treatment, diagnosis, and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or...

20060088530 - Photodynamic therapy treatment for eye disease: This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a...

20060088531 - Human antibodies against human glycoprotein vi and their use: Specific binding members directed to human glycoprotein VI (GPVI), in particular human antibodies, may employ the antibody VH and/or VL domain of the scFv fragment herein termed 10B12 or one or more complementarity determining regions (CDRs) of the 10B12 heavy chain variable (VH) and/or light chain variable (VL) domains, especially...

20060088532 - Lymphatic and blood endothelial cell genes: The invention provides polynucleotides and genes that are differentially expressed in lymphatic versus blood vascular endothelial cells. These genes are useful for treating diseases involving lymphatic vessels, such as lymphedema, various inflammatory diseases, and cancer metastasis via the lymphatic system....

20060088533 - Methods of treating inflammatory bowel disease: Methods for treating intestinal inflammation by inhibiting Clostridium difficile toxin B-mediated activation of the epidermal growth factor receptor or by inhibiting Clostridium difficile toxin B-mediated activation of the extracellular signal-regulated kinase 1/2 are described....

20060088534 - Human anti-factor ix/ixa antibodies: The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting...

20060088535 - Method for enhancing long-term memory in a subject and uses thereof: The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering...

20060088540 - Antagonists and methods for inhibiting angiogenesis: The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple helical forms of the collagen. Antagonists of the invention can target, for example, denatured collagens type-I, type-II, type-III, type-IV, type-V and combinations...

20060088541 - Epha2 as a therapeutic target for cancer: The present invention is directed to compounds and methods for the treatment of cancer. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. The compounds used in accordance with this invention may be provided in a pharmaceutical composition...

20060088539 - Modified antibodies to prostate-specific membrane antigen and uses thereof: Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or antigen-binding fragments thereof, have been rendered less immunogenic compared to their unmodified counterparts to a given species, e.g., a human. Pharmaceutical compositions including the aforesaid antibodies,...

20060088538 - Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent: A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by...

20060088537 - Protein involved in cancer: The present invention relates to new uses of a protein (NKCC1) in the diagnosis, screening, treatment and prophylaxis of breast, lung and/or pancreatic cancer. The invention also provides compositions comprising the protein, including vaccines, antibodies that are immunospecific for the protein and agents which interact with or modulate the expression...

20060088536 - Therapeutic drug using antibody-presenting hollow protein nanoparticles and hollow protein nanoparticles: The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present...

20060088542 - Imidazoquinoline adjuvants for vaccines: The invention relates to the fields of vaccines, vaccine adjuvants, molecular biology and immunology, and generally relates to adjuvants and nucleic acid immunization techniques. More specifically, the invention relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions....

20060088544 - Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions: Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections bonded directly or via a linker or spacer to a second peptide which binds to T cells and which will redirect the immune response from...

20060088543 - Use of passive myostatin immunization: A method to alter the phenotype of animals, e.g., avians, which employs passive and active immunization is provided....

20060088545 - Use of inhibitors of the protease of the human immunodeficiency virus (hiv) to block cell migration and/or invasion, tissue infiltration and oedema for the therary of diseases associated therewith: The present invention relates to a method to block the invasion of normal, neoplastic inflammatory or immune cells, tissue infiltration, and/or oedema formation through inhibition or modulation of molecules and proteolytic enzymes such as—but not exclusively—MMPs, for the therapy of all diseases whose pathogenesis is related to the above processes,...

20060088546 - Antigens for raising an immune response against rickettsieae and ehrlichieae pathogens: The present invention relates to the identification of polypeptides which are useful for raising an immune response against Ehrlichieae and Rickettsieae pathogens when administered into a subject. These polypeptides, and polynucleotides encoding therefor, can be used in various strategies for preventing or treating Ehrlichieae and Rickettsieae infections....

20060088547 - Expression, purification and uses of a plasmodium falciparum liver stage antigen 1 polypeptide: In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) LSA-NRC polypeptide. The method of the present invention produces a highly purified polypeptide which is useful as a vaccine and as a diagnostic reagent....

20060088548 - Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies: The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the...

20060088549 - Chimeric virus vaccine: The present invention provides an immunogenic composition comprising: (a) an isolated recombinant chimeric human rhinovirus, wherein the recombinant chimeric human rhinovirus comprises (i) a nucleic acid having a nucleotide sequence of a human rhinovirus encoding at least a portion of a human rhinovirus capsid; (ii) a heterologous nucleic acid having...

20060088550 - Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively....

20060088551 - Functional fragments of hiv-1 vpr protein and methods of using the same: Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compounds and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1...

20060088552 - Method for inhibiting cell death, cell death inhibitor, and remedy for disease caused by cell death containing the cell death inhibitor: A method according to the present invention for inhibiting cell death includes administrating an anion channel-forming peptide to cells under lactacidosis. The anion channel-forming peptide forms an anion channel on a cell membrane artificially. A cell death inhibitor according to the present invention contains the anion channel-forming peptide. Some of...

20060088553 - Medicament for the treatment of diseases due to infection by neisseria meningitidis: A medicament for the treatment or prevention of diseases due to infection by Neisseria meningitidis, characterized in that it comprises glycoconjugates and/or lipooligosaccharides (LOS) included in outer membrane vesicles, blebs, lipid layers, liposomes and/or killed or commensal bacteria with cross-reactive antigens to Neisseria meningitidis of the serogroup A, B, C,...

20060088554 - Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine: The present invention describes derivatized polysaccharide-protein conjugates, a composition comprising one or more of such derivatized polysaccharide-protein conjugates and methods of immunizing human patients with the same. The derivatized polysaccharide-protein conjugates are purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y, derivatized chemically activated and selectively attached...

20060088555 - Flagellin-based adjuvants and vaccines: The present invention provides adjuvants, vaccines and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. We discovered that flagellin is capable of inhibiting tolerance when it is administered in conjunction with a tolerogenic antigen. This effect is likely mediated by the ability of...

20060088557 - Novel skin care formulation: Skin moisturizing formulations which can be administered in the bath or shower, depositing a thin layer of moisturizing agents on application, which is not rinsed off but remains to protect the skin from drying, resulting in smoother, softer skin feel; the formulations comprising polyvalent metal cations and fatty acids, which...

20060088556 - Topical formulation and use of buspirone: A liquid or semi-solid topical formulation of buspirone, when applied to human epidermis in vitro (following methods defined herein), results in a transepidermal flux rate of buspirone (individual or mean data) in one or more of the following ranges: 0.1 to 1.1 μg/cm2/hour as assessed over 5 hours following application;...

20060088558 - Vitamin e tpgs fluid concentrate comprising a low percentage of water: A liquid Vitamin E TPGS concentrate composition is provided, the concentrate having a significantly higher percentage of TPGS per unit volume than traditional liquid TPGS formulations while providing the TPGS in a liquid form that can be used in softgels or mixed with water to produce desired concentrations for commercial...

20060088562 - Cosmetic compositions: A cosmetic composition having improved transfer resistance comprising: a) from about 0.1-60% by weight of trimethylated silica, b) from about 0.1-60% by weight of a volatile solvent having a viscosity of 0.5 to 100 centipoise at 25° C., c) 0.1-60% by weight of a nonvolatile oil having a viscosity of...

20060088560 - Cosmetic use of mangiferin: The present invention concerns a cosmetic use of mangiferin, or one of its isomers or derivatives, in particular a plant extract containing mangiferin, for example a leaf extract of Aphloia or Mangifera, for preventing and/or reducing the effects caused by heat stress on the skin, lips or hair....

20060088559 - Method for producing anis alcohol: The present invention relates to a method for the preparation of anisalcohol (methoxybenzyl alcohol) by hydrogenation of anisaldehyde (methoxybenzaldehyde) in the presence of Raney nickel and a basic additive, the use of the anisalcohol and hygiene or care products containing anisalcohol....

20060088561 - Pharmaceutical composition for topical application: A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of...

20060088564 - Synergistic and residual pesticidal compositions containing plant essential oils with enzyme inhibitors: Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils in admixture with enzyme inhibitors, with or without other compounds not previously used as active ingredients in pesticidal formulations. In addition, the present invention is directed to a method for controlling pests by applying a pesticidally-effective...

20060088563 - Use of spray adjuvant to enhance the movement of pesticides through plant canopies to the target: Pesticide compositions and methods of using the compositions for killing, inhibiting or repelling pests are disclosed. The pesticide compositions are admixtures of at least one pesticide and a repellent adjuvant. The retention of the pesticide compositions on the foliage of plants is reduced, so that the composition facilitates the penetration...

20060088565 - Device having osteoinductive and osteoconductive properties: The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and...

20060088568 - Implantation of tissue bulking devices: One or more tissue bulking devices are implanted to bulk a structure within a patient. The tissue bulking devices may be implanted between the structure and an adventitial layer that at least partially covers the structure, or within the adventitial layer. In some embodiments, the structure is a luminal wall...

20060088566 - Method of controlling drug release from a coated medical device through the use of nucleating agents: A coated medical device have a drug and a nucleating agent thereon. Also provided are methods of increasing or decreasing the size of drug particles on a coated substrate through the use of nucleating agents to thereby increase or decrease the release rate of the drug from the coated substrate....

20060088567 - Method of manufacturing a medical device having a porous coating thereon: Methods of manufacturing drug-coated medical devices having a porous coatings thereon. The pores are created by solid particle additives added to a mixture comprising a solvent, a drug, and a polymer to create a suspension, which is applied to the medical device. The method includes adding a surfactant to the...

20060088569 - Sheet for guiding regeneration of mesenchymal tissue and production method thereof: To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it,...

20060088570 - Systems and methods for applying cross-linked mechanical barriers: A delivery device applies a biocompatible and biodegradable barrier material to a tissue region, e.g., to seal a vascular puncture site. The material comprises two liquid components, which are pre-packaged in individual dispensers. Upon mixing, the liquid components cross-link to create a barrier matrix. A holder attaches to the delivery...

20060088572 - Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function: Medical devices with polymer coatings designed to control the release of angiotensin-(1-7) receptor agonists from medical devices are disclosed. The present application also discloses providing vascular stents with angiotensin-(1-7) receptor agonist-containing controlled-release coatings. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients...

20060088571 - Biocompatible and hemocompatible polymer compositions: Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings. Additional embodiments of the present invention...

20060088573 - Composition having action preventing or alleviating symtoms or diseases due to aging of blood vessels: A composition and food or beverage containing arachidonic acid or a compound having arachidonic acid as a component fatty acid and having an action preventing or alleviating symptoms or diseases due to aging of the blood vessels....

20060088575 - Homeopathic preparations of purified growth factors and purified growth hormones and associated carriers: A preparation comprising a homeopathic potency of a purified composition, such as insulin-like growth factor, insulin-like growth factor-1 (IGF-1), growth hormone, transforming growth factor (TGF), TGFβ1, fibroblast growth factor (FGF), FGF1, FGF2, GM-CSF, M-CSF, PDGFββ, nerve growth factor (NGF) and epidermal growth factor (EGF), is provided. The concentration of the...

20060088574 - Nutritional supplements: The invention provides nutritional supplements for an oral or enteral administration to humans, whether in satisfactory health, or having a medical condition. These supplements can provide humans with a complete, balanced nutrition in a bioavailable form, either as a food supplement or as a meal replacement, and preferably includes one...

20060088576 - Method for enhancing milk production: The present invention concerns a method of enhancing milk production by a ruminant that includes providing a feed that contains sorbitol and at least one additional feed component, and orally feeding the feed to the ruminant, the ruminant ingesting about 100 grams, or less, of sorbitol per day....

20060088578 - Biopolymeric membranes: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The...

20060088577 - Process for manufacturing fibrin membranes and fibrin membranes obtained according to this process: A process for manufacturing a fibrin membrane from blood plasma that was partially depleted and subjected to coagulation by adding a solution of a physiological coagulating agent, leaving the mixture to stay until forming a gelatinous blood clot, and then dehydrating said blood clot to obtain a fibrous membrane, which...

20060088579 - Transdermal drug delivery systems: One aspect of the invention provides a transdermal delivery system including a drug formulated with a transport chaperone moiety that reversibly associates with the drug. The chaperone moiety is associated with the drug in the formulation so as to enhance transport of the drug across dermal tissue and releasing the...

20060088581 - Device for delivery of therapeutic agent: The invention provides a system for administering to or through the skin of the individual selected medicaments. The system includes an orthosis and a pad. The pad includes at least one delivery station suitable for containing the medicament. The pad may be positioned in a variety of configurations on the...

20060088580 - Hormone-containing transdermal therapeutic system with an active substance reservoir based on vinylacetate-vinylpyrrolidone copolymer with improved cohesion: A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least...

20060088583 - Artificial oxygen carrier containing preventive agents of methb formation: The present invention provides an agent containing L-tyrosine that prevents methemoglobin formation, and a vesicle comprising the above agent for preventing methemoglobin formation. More specifically, the present invention provides an oxygen infusion preparation suitable for long-term storage, which prevents an increase in methemoglobin content as a result of oxidation of...

20060088584 - Liposomal formulations of hydrophobic photosensitizer for photodynamic therapy: Pharmaceutical liposomal formulations are described for photodynamic therapy comprising a, hydrophobic porphyrin photosensitizer, a monosaccharide and one or more synthetic phospholipids, which are stable in storage especially through freeze-drying process. The liposomal formulations provide therapeutically effective amounts of the photosensitizer for intravenous administration. In particular derivatives of chlorins and bacteriochlorins,...

20060088582 - Phosphatidyl oligo glycerins and structural analogs: This invention relates to novel structural analogs to phosphatidyl oligo glycerins. These compounds can be used, in particular, for producing liposomes having a long circulation time with or without thermolability. The invention also relates to liposomes containing compounds of the aforementioned type and to medicament compositions....

20060088585 - Dosage forms having a microreliefed surface and methods and apparatus for their production: The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of...

20060088586 - Dosage forms having a microreliefed surface and methods and apparatus for their production: The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of...

20060088587 - Dosage forms having a microreliefed surface and methods and apparatus for their production: The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of...

20060088588 - Medication administering device and system: A suppository method and device for taking or administering “over-the-counter” and prescription including a capsule formed by a dissolvable material and specific quantity of a predetermined medication stored or storable in the capsule and sterilized light-resistant, moisture-proof foil peel-back packet for storage and packaging prior to use, which may be...

20060088589 - Reinforced absorbable multilayered hemostatic wound dressing: The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen....

20060088590 - Non-blooming gelatin and non-gelatin formulations: A non-blooming plasticizer composition and methods of using the composition are described herein. The composition is a mixture of sorbitol and sorbitan wherein the ratio of sorbitan and sorbitol is between about 0.40 and about 1.2 by weight, more preferably from about 0.45-0.50 to about 0.70 by weight, wherein the...

20060088593 - Dosage forms having a microreliefed surface and methods and apparatus for their production: The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of...

20060088594 - Highly compressible controlled delivery compositions of metformin: Highly compressible controlled delivery compositions of metformin or salts thereof and the process of making the same are disclosed. Metformin is granulated with a binder and further dispersed in a rate-controlling matrix that results in increased hardness and decreased friability thereby effectively solving compressibility difficulties arising for Metformin formulations....

20060088592 - Oral formulation for delivery of poorly absorbed drugs: A composition for oral delivery of a poorly absorbed drug is disclosed. The composition includes the drug, an enhancer for increasing absorption of the drug through the intestinal mucosa, a promoter, which alone does not increase absorption of the drug through the intestinal mucosa, but which further increases the absorption...

20060088591 - Tablets from a poorly compressible substance: A solid composition suitable for forming into a tablet includes a pharmaceutically active substance in an amount sufficient to provide a therapeutic effect when administered; from about 0.2 to about 15 weight %, based on the total weight of the composition, of a water-soluble preparation of a fat-soluble vitamin; and...

20060088595 - Dispersant for sustained release preparations: The present invention provides a bilayer dispersing agent for a sustained-release preparation, which contains a non water-soluble solvent and an aqueous solvent, and a sustained-release preparation wherein a microcapsule containing a physiologically active substance is dispersed in the aforementioned dispersing agent. When this preparation is subcutaneously administered, the initial release...

20060088596 - Solubilizing a drug for use in a coating: A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is...

20060088597 - Agent delivery system: A delivery vehicle including a mixture of: a) an effective amount of an expander activatable by a wetting agent and, b) a treatment agent. The expander and treatment agent intermingled and compressed so as to form a substantially solid delivery vehicle. The solid delivery vehicle, on exposure to a volume...

20060088599 - Amino functionalized ormosil nanoparticles as delivery vehicles: Provided are amino functionalized ORMOSIL nanoparticles. Also provided are compositions comprising such particles and compositions in which the nanoparticles are complexed to polynucleotides. The complexing of polynucleotides to the amino functionalized ORMOSIL nanoparticles protects the polynucleotides from environmental damage. These complexes can be used for delivery of polynucleotides to cells....

20060088598 - Intravenous composition, process for producing the same and preparation thereof: A composition for intravenous injection, which gradually decomposed instead of fat particles, has sufficient sustained release effects, has an excellent encapsulation ratio of lipid-soluble agents, and has such sustained release effects at lesion sites; a production method thereof; and a preparation containing the composition. The composition for intravenous injection is...

20060088600 - Treatment for dry eye syndrome: A novel formulation for the treatment of the many underlying inflammatory processes that cause dry eye syndrome. In particular, the formulation, which is orally administered includes the optimal blend of omega-3 and omega-6 essential fatty acids, and nutrient cofactors necessary to enhance the metabolic conversion associated with the tear-specific series...

20060088601 - Synthetic bone substitute material: The invention includes a synthetic bone substitute material suitable for use as a replacement for cancellous bone in a bone graft composition, the material comprising a reticulated framework of interconnecting bioceramic struts defining an interconnecting interstitial void volume, and a solid non-porous composition substantially filling the interstitial void volume and...

20060088602 - Electromagnetic field regulating compositions: A cosmetic or pharmaceutical emulsion composition that is topically applied to the skin to protect it against damage caused by electromagnetic field generated from everyday appliances such as televisions, computers and cellular phones. The compositions contain ambient electromagnetic wave dampening effective amounts of at least one single domain magnet as...

20060088603 - Compositions and methods for nutrition supplementation: The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or lactating subjects....

20060088604 - Therapeutic ointment for treating dermatological infections and method of using same: A therapeutic ointment that includes (a) a skin protecting agent, (b) an anti-inflammatory agent, and (c) an antibiotic composition, and a method of using the ointment to treat mammals suffering from dermatological infections....

20060088605 - Preservative compositions for materials and method of preserving same: Preservative composition for various materials and method of preserving the same is disclosed. The preservative composition includes at least one silane-containing material and at least one hydrocarbon solvent containing molecules of at least five carbon atoms....

20060088606 - Methods and compositions for use in perfusion applications: Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the...

20060088607 - Nutritional supplement compositions: Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6β-glucuronide are provided....

20060088609 - Compositions containing cotinus coggygria extract and use thereof on mucosal tissues: The present invention relates to a method of enhancing the mucus production of mucosal tissue by administering to mucosal tissue in need of such enhancement a composition containing a safe and effective amount of Cotinus coggygria extract....

20060088608 - Compositions containing cotinus coggygria extract and use thereof on skin and mucosal tissues: The present invention relates to a method of enhancing the elasticity or structural integrity of skin or mucosal tissue by administering to skin or mucosal tissue in need of such enhancement a composition containing a safe and effective amount of Cotinus coggygria extract....

20060088610 - Anti-inflammatory cranberry flavonol extract preparations: The present invention is directed to extracts of cranberries (Vaccinium macrocarpon) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-β-xylopyranoside, quercetin-3-β-glucoside, quercetin-3-α-arabinopyranoside, 3′-methoxyquercetin-3-α-xylopyranoside, quercetin-3-O-(6″-p-coumaroyl)-β-galactoside, and quercetin-3-O-(6″-benzoyl)-β-galactoside. The present invention also embodies the use of those extracts, as well as...

20060088611 - Morinda citrifolia-based formulations and methods for weight management: The present invention relates to formulations and methods for weight management utilizing processed Morinda citrifolia products or extracts. Specifically, the present invention relates to formulations, which may be used for weight loss, regulating gastric motility and regulating plasma levels of cholecystokinin....

20060088612 - Composition for treatment of topical infection and methods of making and using same: Compositions and methods for the prevention and treatment of topical infections using essential oil or extract from Minthostachys mollis (Peperina) or other herbs of the family Lamiaceae, or any combination of its individual chemical components and an acceptable carrier are disclosed....

20060088613 - Simmondsin for use as angiogenesis inhibitor: The present invention relates to the use of an active component derived from jojoba, and in particular a simmondsin, steroisomeric forms, racemic mixtures, metabolites, pharmaceutically acceptable esters or salts thereof, or mixtures thereof for the manufacture of a medicament for inhibiting angiogenesis and for the manufacture of a medicament for...

20060088614 - Compounds, compositions and methods for treating neuropsychiatric disorders: Acetyl-L-carnitine (ALCAR) and L-carntine (LCAR) are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to enhance ALCAR and LCAR formation in germinating plant seeds. Metabolic fluxes are manipulated by germination in bioreactors to increase oxygen availability as well as provide an...

20060088616 - Compositions containing malva sylvestris extract and use thereof on mucosal tissues: The present invention relates to a method of enhancing the mucus production of mucosal tissue by administering to mucosal tissue in need of such enhancement a composition containing a safe and effective amount of Malva sylvestris extract....

20060088615 - Compositions containing malva sylvestris extract and use thereof on skin and mucosal tissues: The present invention relates to a method of enhancing the elasticity or structural integrity of skin or mucosal tissue by administering to skin or mucosal tissue in need of such enhancement a composition containing a safe and effective amount of Malva sylvestris extract....

20060088617 - Chocolate composition and method for benefiting the cardiovascular system: A medicinal or food supplement composition comprised essentially of dark chocolate less most of the fat and sugar and with high levels of chocolate flavonoids, and a method by which the composition is consumed by a person or other mammal in specified doses per day over a period of time,...

20060083679 - Agents with selective k-opioid receptor affinity: Compounds and compositions that are salvinorin A and salvinorin B derivatives that demonstrate selectivity and/or potency for the k-opioid receptor (KOR), allowing for their use as medicines, as well as chemical probes (both radiolabeled and cold) for fields utilizing the techniques of radiolabeled binding assays....

20060083681 - Compounds for myocardial perfusion imaging: The present disclosure is directed to compounds comprising imaging moieties and their use for diagnosing certain disorders....

20060083680 - Diphenyl ether derivatives and their use for imaging serotonin transporters: This invention relates to diphenyl ether derivatives and their use in imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a...

20060083682 - Novel methods of cancer therapy targeted against a cancer stemline: Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment....

20060083678 - Radio-labeled compounds, compositions, and methods of making the same: 18F radio-labeled compounds, methods of making the radio-labeled compounds, and applications of the same are disclosed....

20060083676 - Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands: In a preferable embodiment, X represents O; R1 represents C1-6alkyl; cycloC3-12alkyl or (cycloC3-12alkyl)C1-6alkyl, wherein one or more hydrogen atoms in a C1-6alkyl-moiety or in a cycloC3-12alkyl-moiety optionally may be replaced by C1-6alkyloxy, aryl, halo or thienyl; R2 represents hydrogen; halo; C1-6alkyl or amino; R3 and R4 each independently represent hydrogen...

20060083677 - Solid-phase fluorination of benzothiazoles: The invention provides a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I) SOLID SUPPORT-LINKER-X-TRACER (I) wherein X is a group which promotes nucleophilic substitution at a specific site on the attached TRACER and the TRACER is of formula (A)....

20060083683 - Antibody fragment-polymer conjugates and uses of same: Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also...

20060083684 - Method of radio-labelling biomolecules: A method of radio-labelling a biomolecule comprising contacting the biomolecule with a source of radionuclide, such as technetium, in the presence of a weak transfer ligand and optionally subsequently passing the mixture through a size-exclusion filtration process. Also claimed are kits comprising such novel compositions, especially lactoferrin coupled to chemotherapeutic...

20060083685 - Opioid metallopeptide compositions and methods: Metallopeptides and metallopeptide combinatorial libraries specific for opioid receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one...

20060083686 - Therapeutic agent for ulcerative colitis: Disclosed are pharmaceutical compositions of treatment for a patient with ulcerative colitis comprising a drug which can selectively kill Fusobacterium varium cells, or a drug which can neutralize the toxin produced by Fusobacterium varium cells, a method for screening such a drug, a method for treating a patient with the...

20060083687 - Method and system of obtaining improved data in perfusion measurements: A method of deriving blood perfusion indices for a region of interest (ROI) of a subject, comprising the steps of administering a contrast agent to the subject during a dynamic imaging scan, converting signal intensity data from raw images of the scan into contrast agent concentration data, deriving parameters from...

20060083689 - Contrast enhancement agent for magnetic resonance imaging: Imaging agents for magnetic resonance imaging are disclosed. Methods of monitoring angiogenesis and the growth and remission of tumor tissue are also disclosed. Methods of monitoring blood clot formation and dissolution are additionally disclosed. Methods of monitoring wound healing are further disclosed. A kit for obtaining an image of a...

20060083688 - Optical determination of glucose utilizing boronic acid adducts: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to...

20060083690 - Less abusable pharmaceutical preparations: The present invention is directed to pharmaceutical compositions of psychoactive drugs having a reduced potential for abuse and methods of reducing the potential for abuse of dosage forms of prescription psychoactive drugs....

20060083692 - Combination of formoterol and a tiotropium salt: A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically acceptable acid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease....

20060083691 - Intranasal opioid compositions, delivery devices and methods of using same: The present invention relates to pharmaceutical compositions comprising opioids and a liquid nasal carrier, to delivery devices comprising such compositions, and to methods of manufacture and use of such compositions....

20060083693 - Stable pharmaceutical solution formulations for pressurised metered dose inhalers: An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using...

20060083694 - Multi-component particles comprising inorganic nanoparticles distributed in an organic matrix and processes for making and using same: Multi-component particles comprising inorganic nanoparticles distributed in an organic matrix and processes for making and using same. A flowing aerosol is generated that includes droplets of a precursor medium dispersed in a gas phase. The precursor medium contains a liquid vehicle and at least one precursor. At least a portion...

20060083695 - Sweetener composition: Storing monatin or a salt thereof in the presence of a radical scavenger and/or in a UV light-shielding container is effective for preventing the decomposition of monatin or a salt thereof by exposure to ultraviolet light, particularly under acidic conditions. Sweetener compositions which contain monatin or a salt thereof and...

20060083696 - Composition cosmetique comprenant un polymere acrylique: an organic solvent phase comprising at least one first organic solvent, the said phase being free of lower monoalcohol containing from 1 to 5 carbon atoms or of C3-C4 ketone, or containing them in a weight content, relative to the total weight of the composition, of less than or equal...

20060083698 - Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s): Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one oil containing at least one amide structural unit and (iii) at least one compound accepting the excited triplet level energy of...

20060083699 - Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s): Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane...

20060083697 - Topical skin lightening cream: The present invention is a novel topical composition for the treatment of non-congenital dermal blemishes comprising, hydroquinone wherein the concentration of hydroquinone is not less than 2 percent and not more than 12 percent, tretinoin wherein the concentration of tretinoin is not less than 0.01 percent and not more than...

20060083700 - Use of a novel phytonutrient rich bioactive concentrate (ri-activetm) for the prevention and treatment of cardiovascular disease, diabetes and other health disorders: The present invention is generally related to the discovery of the use of a novel composition (Ri-Active™), containing a concentrate of the bioactives, micronutrients and antioxidants present in the unsaponifiable fraction of rice bran oil or rice germ oil, in the prevention and treatment of health disorders. The novel use...

20060083701 - Nail enamel compositions, related methods, and a two component kit for painting the nails: A nail enamel composition comprising, by weight of the total composition, about 10-95% solvent, and 5-95% of a film forming polymer having a glass transition temperature in the range of 5 to 90° Centigrade, and containing about 2 to 29% by weight of the total polymer of at least one...

20060083703 - Hair conditioning composition comprising polyol esters containing alkyl chains: A hair conditioning composition comprising polyol esters containing alkyl chains and a gel matrix. The composition of the present invention can provide improved conditioning benefits such as smooth feel and reduced friction to both damaged hair and non-damaged hair, while providing other benefits such as slippery and slick feel on...

20060083704 - Hair conditioning composition comprising high internal phase viscosity silicone copolymer emulsions: A hair conditioning composition comprising silicone copolymer emulsions with an internal phase viscosity of greater than about 120×106 mm2/sec and a gel matrix. The composition of the present invention can provide improved conditioning benefits such as smooth feel and reduced friction to both damaged hair and non-damaged hair, while providing...

20060083705 - Vinyl lactam/vinyl carbazole copolymers: A copolymer of a vinyl lactam and vinyl carbazole useful in personal care compositions....

20060083706 - Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant: Disclosed herein is a haircare composition comprising, in a cosmetically acceptable medium, at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant....

20060083702 - Hair fiber treating method: The present disclosure relates to a hair fiber treatment method without a hair fixing step. This method includes applying a reducing composition containing no ceramide onto hair fibers, and raising the temperature of the hair fibers with a heating iron at a temperature of at least 60° C. The reducing...

20060083708 - Composition using mineral salts for cosmetic or therapeutic treatment: A cosmetic and tissue cleansing composition including mineral salts, preferably Dead Sea Mineral Salts, Tea Tree Extract and Urea as an effective agent to minimize the effect of itching on the skin from a condition caused by psoriasis. In another form, the composition can be used as an exfoliating or...

20060083707 - Facial pack and bathing compositions based on hwangto (korean loess) and preparation thereof: Disclosed are a facial pack composition and a bathing composition based on loess, and methods for preparing the same. The bathing composition makes a user feel refreshed, prevents arteriosclerosis and fat accumulation in human bodies, is useful for the treatment of maturating diseases such as dermatophytosis and dermatitis and stimulates...

20060083710 - Process for making antimicrobial polymer articles: This invention relates to a process for making articles antimicrobial and odor inhibiting, which comprises using vacuum deposition and electron beam techniques to graft amino-reactive functional groups onto polymeric material which the article comprises, followed by contacting the polymeric material with a chitosan solution....

20060083709 - Sustained release air freshening device: This invention relates to a device that provides controlled release of a fragrant or deodorizing substance: the fragrant or deodorizing substance being solublized with an appropriate carrier solvent within a polymeric matrix. The layers function as protective barriers, semi-permeable membranes, fragrance reservoirs, and adhesives. The device is capable of delivering...

20060083711 - Methods and products related to the intracellular delivery of polysaccharides: The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as...

20060083712 - Methods and compositions for the repair and/or regeneration of damaged myocardium: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of stem cells, such as adult stem cells, optionally with cytokines are disclosed and claimed....

20060083713 - Methods of using a human il-17 related polypeptide to treat disease: Methods are provided for the treatment or prevention of atherosclerosis, allergic autoimmune diseases, endothelial cell apoptosis, allograft vasculopathy, hypertension, congestive heart failure, ischemia/reperfusion injury, type 1 diabetes, inflammation, immunodeficiencies, cancers, and infectious diseases by administering a human IL-17 related polypeptide and/or an antibody recognizing an epitope thereof to a patient...

20060083714 - Combination of a pde iv inhibitor and a tnf-alpha antagonist: The subject invention relates to therapeutic combinations and methods for the treatment of inflammatory conditions and diseases. Particularly the present invention relates to treatments and methods for PDE IV-related conditions and for TNF-alpha-related conditions using a combination of a PDE IV inhibitor and a TNF-alpha antagonist....

20060083715 - Interferon beta-like molecules for treatment of stroke: The present invention relates to use of interferon beta-like polypeptides for treatment of stroke or transient ischemic attach in a primate, preferably in a human. More particularly, the interferon beta-like polypeptides differs from the amino acid sequence of wild-type human IFNB (SEQ ID NO:2) in that at least one glycosylation...

20060083716 - Composition for delivering an agent to a target cell and uses thereof: The present invention provides a composition for delivering an agent to a target cell, comprising: (a) a microorganism that has, on its cell surface, at least one exogenous molecule that binds to an antigen on the surface of a target cell; and (b) an agent. The present invention further provides...

20060083717 - System and method for forming a non-ablative cardiac conduction block: A system forms a cardiac conduction block at a location in a heart of a patient, generally without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue but that substantially interrupts and thus blocks...

20060083718 - Novel therapy for lysosomal enzyme deficiencies: The present invention provides a therapeutic delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload trapping molecule and a payload molecule, wherein the payload molecule and the payload trapping molecule are soluble in the same solvent system wherein the payload molecule supplements the function of the deficient...

20060083722 - Methods and compositions for cell therapy: Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human mammal transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate...

20060083724 - Compositions for the treatment of femal sexual dysfunction: The compositions and methods disclosed herein are of use for the treatment of female sexual dysfunction. The disclosed compositions and methods pertain to topical formulations including at least three vasodilating agents that act by different physiological pathways, and at least one sensory or functional additive....

20060083723 - Novel microorganism strain gm-090 of lactobacillus fermentum and its use for stimulating ifn-y secretion and/or treating allergy: The present invention provides an isolated microorganism strain, Lactobacillus fermentum GM-090, which is found to be effective in stimulating IFN-γ secretion and/or treating allergy. The use of the Lactobacillus fermentum GM-090 in stimulating IFN-γ secretion and/or treating allergy is also provided....

20060083725 - Suppression of root and tuber disease: Methods are provided for suppressing bacterial and fungal disease in roots and tubers by treating the plant tissue, seed, and surrounding soil with Bacillus firmus bacteria....

20060083726 - Method for controlling insects of the order diptera using a bacillus thuringiensis strain: The invention provides a method for controlling insects of the Order Diptera by providing a Bacillus thuringiensis strain or variant thereof, or a spore or crystal of the Bacillus thuringiensis strain or variant thereof, and either contacting the insect with or administering to an animal the Bacillus thuringiensis strain or...

20060083719 - Fixed-dried red blood cells: Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by...

20060083721 - Injectable cross-linked polymeric preparations and uses thereof: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic...

20060083720 - Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions: Adipose derived regenerative cells are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells, e.g., stem and/or progenitor cells, obtained from the adipose tissue to a patient. The methods may be...

20060083728 - Acellular matrix implant for treatment of cartilage lesions, injuries and defects: An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted...

20060083729 - Biocompatible tissue sealant for treatment of osteochondral and bone defects using an acellular matrix implant: An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted...

20060083730 - Method for treatment of osteochondral and bone defects using an acellular matrix implant: An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted...

20060083727 -