Diagnostics and treatments of periodontal disease

Title: Diagnostics and treatments of periodontal disease

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Dentifrices (includes Mouth Wash), Ferment Containing (e.g., Enzymes, Bacteria, Etc.)

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20070189982, Diagnostics and treatments of periodontal disease.

1-11. (canceled)

12. An antibody preparation comprising antibodies specifically directed against a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis, the complex comprising at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa.

13. An antibody preparation as claimed in claim 12 in which the antibodies are polyclonal antibodies.

14. An antibody preparation as claimed in claim 12 in which the antibodies are monoclonal antibodies.

15. A method of treating a subject suffering from Porphyromonas gingivalis infection, the method comprising administering to the subject an amount of the antibody preparation as claimed in claim 12 effective to at least partially neutralize the PrtR-PrtK complex of Porphyromonas gingivalis.

16. A method as claimed in claim 15 in which the antibody preparation is administered as a mouth wash or as a dentifrice.

17. A method of reducing the prospect of P. gingivalis infection in an individual and/or severity of disease, the method comprising administering to the individual an amount of the composition as claimed in claim 11 effective to induce an immune response in the individual directed against P. gingivalis.

18. A recombinant host cell, the host cell being transformed with a DNA sequence(s) encoding PrtR-PrtK operatively linked to control sequences such that under appropriate conditions the host cell expresses PrtR-PrtK.

19. A recombinant host cell as claimed in claim 18 in which the host cell is an oral commensal.

20. A recombinant host cell as claimed in claim 18 in which the host cell is transformed with the DNA sequences shown in FIG. 8b and FIG. 9b.

Brief Patent Description - Full Patent Description - Patent Claims

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Compositions and methods for treating alopecia
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Porphorymonas gingivalis polypeptides and nucleotides
Industry Class:
Drug, bio-affecting and body treating compositions

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