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Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens




Title: Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens.
Abstract: The present invention concerns methods for detecting a nucleic acid comprising (i) contacting a solution comprising a first PNA having a first cross-reactive functional group with a substrate having a second PNA affixed thereto, the second PNA having a second first cross-reactive functional group, wherein the first PNA has a reporter molecule attached thereto and the first and second PNAs being complementary to different portions of a target DNA; (ii) contacting a sample suspected of containing the nucleic acid with the first and second PNAs; and (iii) determining the presence of the reporter molecule on the substrate. ...


USPTO Applicaton #: #20120107794
Inventors: Daniel H. Appella, Christopher Micklitsch


The Patent Description & Claims data below is from USPTO Patent Application 20120107794, Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens.




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stats Patent Info
Application #
US 20120107794 A1
Publish Date
05/03/2012
Document #
12409159
File Date
03/23/2009
USPTO Class
435/5
Other USPTO Classes
435/611
International Class
/
Drawings
7




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Chemistry: Molecular Biology And Microbiology   Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip   Involving Virus Or Bacteriophage  

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20120503|20120107794|cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens|The present invention concerns methods for detecting a nucleic acid comprising (i) contacting a solution comprising a first PNA having a first cross-reactive functional group with a substrate having a second PNA affixed thereto, the second PNA having a second first cross-reactive functional group, wherein the first PNA has a |
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