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Compositions of natural products and use thereofRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Plant Material Or Plant Extract Of Undetermined Constitution As Active Ingredient (e.g., Herbal Remedy, Herbal Extract, Powder, Oil, Etc.), Containing Or Obtained From Leguminosae (e.g., Legumes Such As Soybean, Kidney Bean, Pea, Lentil, Licorice, Etc.)Compositions of natural products and use thereof description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060275517, Compositions of natural products and use thereof. Brief Patent Description - Full Patent Description - Patent Application Claims
FIELD OF THE INVENTION [0001] The present invention relates to compositions comprising a combination of hops isoalpha acids and particular isoflavones. BACKGROUND OF THE INVENTION [0002] Isoflavones are known as compounds that can be applied to prevent or treat many health deficiencies or to achieve certain health effects not directly related with a health deficiency. For example, they are known to achieve benefits in the women's health area, in particular for postmenopausal women. Health effects that are also attributed to isoflavones include skin anti-ageing effects and anti-inflammatory effects. [0003] Hop materials have been used for many years to impart a distinctive, bitter flavour to brewed beverages. Hop plants are in the Cannabinaceae family. Hop materials used in the production of beer and other brewed beverages are primarily derived from a plant in the genus Humulus known as Humulus lupulus L. The key flavouring ingredients obtained from hop plants reside within cone-like structures which are harvested and used in manufacturing brewed beverages. The primary flavouring ingredients in hop cones are compounds known as alpha-acids, which are converted to isoalpha acids during the boiling process. SUMMARY OF THE INVENTION [0004] We have now found that the isoalpha acids found in hops and hop extracts can act synergistically in combination with certain isoflavones, in particular in down-regulating the production of prostaglandin E.sub.2, part of the inflammatory response, following oxidative stress. Accordingly, a combination of hops isoalpha acids and isoflavones can be used to achieve anti-ageing and anti-inflammatory effects. [0005] Accordingly, in a first aspect, the present invention provides a composition comprising hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitin, wherein the weight ratio of hops isoalpha acid extract to isoflavones is from 1:50 to 50:1, calculated as aglucon. [0006] Preferably, the composition comprises genistein/genistin and daidzein/daidzin, preferably present in a weight ratio of genistein/genistin to daidzein/daidzin of from 2:1 to 1:2, calculated as aglucon, more preferably from 2:1 to 1:1 It is also preferred that the composition comprises glycitein and/or glycitin. [0007] Preferably the isoflavones are derived from leguminous plants, more preferably soy. [0008] In a preferred embodiment, the hops isoalpha acids are selected from unreduced isoalpha acids, dihydro-isoalpha acids and tetrahydro-isoalpha acids, and mixtures thereof. [0009] In a second aspect, the present invention provides a dosage form comprising a composition of the invention, wherein the dosage form comprises from 10 mg to 200 mg of said hops isoalpha adds and from 10 mg to 200 mg of said isoflavones. Preferably the dosage form is an oral dosage form such as a tablet. [0010] In a third aspect, the present invention provides a food product which comprises a composition of the invention. Preferably the amount of said hops isoalpha acids and said isoflavones present in the food product is from 20% to 100% of the total recommended daily intake (=RDI amount) of the hops isoalpha acids and isoflavones per serving. [0011] In a preferred embodiment, the food product contains 20 mg to 400 mg of a combination of said hops isoalpha acids and said isoflavones, per recommended serving. [0012] The present invention also provides a method of promoting the formation of collagen and/or decorin in the skin of an individual which method comprises administering to the individual an effective amount of a combination of hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitin. [0013] The present invention further provides a method of reducing the effects of ageing on the skin of an individual which method comprises administering to the individual an effective amount of a combination of hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitin. [0014] In another aspect, the present invention provides a method of treating or preventing the effects of inflammation in an individual, which method comprises administering to the individual an effective amount of a combination of hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitin. [0015] The present invention also provides a composition comprising a combination of hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitn for use in promoting the formation of collagen and/or decorin in the skin of an animal or human; for use in reducing the effects of ageing on the skin of an animal or human; and/or for use in treating or preventing the effects of inflammation in an animal or human. [0016] In a related aspect, the present invention provides the use of a health composition comprising a composition or food product of the invention wherein the composition or food product is applied to achieve skin benefits and skin related effects such as anti-ageing effects or for promoting the formation of collagen or for promoting the decorin formation in the skin. Also provided is the use of said health composition wherein the composition is applied for the production of a functional food with anti-inflammatory properties. [0017] Also provided is a method for the treatment or prevention of inflammations and related health deficiencies in animals or humans by administering to an animal or human in one or more servings in total an effective amount of a composition or food product of the invention. [0018] The present invention also provides a method to achieve skin benefits or skin related effects, respectively to achieve the promotion of collagen formation or decorin formation in the skin by administering to an animal or human in one or more servings per day in total an effective amount of a composition or a food product of the invention. DETAILED DESCRIPTION OF THE INVENTION [0019] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Isoalpha Acids Continue reading about Compositions of natural products and use thereof... Full patent description for Compositions of natural products and use thereof Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Compositions of natural products and use thereof patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. 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