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12/15/05 - USPTO Class 514 | 181 views | #20050277607 | Prev - Next | About this Page

Compositions and methods for regulating peptidyltransferase activity and uses thereof

Title: Compositions and methods for regulating peptidyltransferase activity and uses thereof

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), O-glycoside, , Nitrogen Containing Hetero Ring, Polynucleotide (e.g., Rna, Dna, Etc.)

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20050277607, Compositions and methods for regulating peptidyltransferase activity and uses thereof.

What is claimed is:

1. A method of identifying a composition which inhibits peptidyl transferase activity by inhibiting the interaction of L41 with ribosomes, comprising the steps of: a) contacting a test composition with a cell, cell extract, or purified cell components containing L41 and ribosomes; b) detecting whether the test composition specifically inhibits the interaction of L41 with the ribosomes; and c) determining whether the test composition inhibits peptidyl transferase activity of the ribosomes.

2. The method of claim 1 wherein the cell or cell extract is from yeast.

3. The method of claim 1 wherein the determining step comprises detecting a decrease in the rate of peptidylpuromycin formation by the ribosomes.

4. A composition identified in accordance with the method of claim 1.

5. A method of inhibiting peptidyl transferase activity in a cell comprising contacting the cell with a composition of claim 4.

6. A method of inhibiting a viral infection in a cell comprising contacting the cell with an effective amount of a composition of claim 4.

7. A method of treating a viral infection in a patient comprising administering to the patient, a therapeutically effective amount of a composition of claim 4.

8. A pharmaceutical composition comprising the composition of claim 4 and a pharmaceutically acceptable carrier.

9. A method of identifying a composition which increases -1PRF efficiencies by inhibiting the interaction of L41 with ribosomes comprising the steps of: a) contacting a test composition with a cell, cell extract, or purified cell components, containing L41 and ribosomes; b) detecting whether the test composition inhibits the interaction of L41 with the ribosomes; and c) determining whether the test composition increases -1PRF efficiencies of the ribosomes.

10. The method of claim 9 wherein the host cell is a yeast cell.

11. The method of claim 9 wherein the determining step comprises an assay of programmed ribosomal frameshifting.

12. A composition identified in accordance with the method of claim 9.

13. A method of increasing -1PRF efficiencies in a cell comprising contacting the cell with a composition of claim 12.

14. A method of inhibiting a viral infection in a cell comprising contacting the cell with an effective amount of a composition of claim 12.

15. A method of treating a viral infection in a patient comprising administering to the patient, a therapeutically effective amount of a composition of claim 12.

16. A pharmaceutical composition comprising the composition of claim 12 and a pharmaceutically acceptable carrier.

17. A composition which inhibits the interaction of L41 with ribosomes and thereby decreases peptidyl transferase activity.

18. The composition of claim 17 comprising a small molecule.

19. A pharmaceutical composition comprising the composition of claim 17 and a pharmaceutically acceptable carrier.

20. A method for treating a viral infection in a patient comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition of claim 19.

Brief Patent Description - Full Patent Description - Patent Claims

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Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
Industry Class:
Drug, bio-affecting and body treating compositions

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