| Compositions and medical devices utilizing bioabsorbable polymeric waxes -> Monitor Keywords |
|
|
 
Compositions and medical devices utilizing bioabsorbable polymeric waxesRelated Patent Categories: Stock Material Or Miscellaneous Articles, Hollow Or Container Type Article (e.g., Tube, Vase, Etc.), Polymer Or Resin Containing (i.e., Natural Or Synthetic)Compositions and medical devices utilizing bioabsorbable polymeric waxes description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060210747, Compositions and medical devices utilizing bioabsorbable polymeric waxes. Brief Patent Description - Full Patent Description - Patent Application Claims
FIELD OF THE INVENTION [0001] The present invention relates to bioabsorbable and biocompatible polymeric waxes for use in pharmaceutical, agricultural and medical applications. BACKGROUND OF THE INVENTION [0002] Both natural and synthetic polymers, including homopolymers and copolymers, which are both biocompatible and absorbable in vivo are known for use in the manufacture of medical devices that are implanted in body tissue and absorb over time. Examples of such medical devices include suture anchor devices, sutures, staples, surgical tacks, clips, plates and screws, drug delivery devices, adhesion prevention films and foams, and tissue adhesives. [0003] Natural polymers may include catgut, cellulose derivatives and collagen. Natural polymers typically absorb by an enzymatic degradation process in the body. [0004] Synthetic polymers may include aliphatic polyesters, polyanhydrides and poly(orthoester)s. Synthetic absorbable polymers typically degrade by a hydrolytic mechanism. Such synthetic absorbable polymers include homopolymers, such as poly(glycolide), poly(lactide), poly(.epsilon.-caprolactone), poly(trimethylene carbonate) and poly(p-dioxanone), and copolymers, such as poly(lactide-co-glycolide), poly(.epsilon.-caprolactone-co-glycolide), and poly(glycolide-co-trimethylene carbonate). The polymers may be statistically random copolymers, segmented copolymers, block copolymers or graft copolymers. [0005] Alkyd-type polyesters prepared by the polycondensation of a polyol, polyacid and fatty acid are used in the coating industry in a variety of products, including chemical resins, enamels, varnishes and paints. These polyesters also are used in the food industry to make texturized oils and emulsions for use as fat substitutes. [0006] There is a great need for polymers for use in drug delivery and medical devices, where the polymers have both low melting temperatures and low viscosities upon melting, thus permitting for solvent-free processing techniques in preparation of medical devices and compositions, can crystallize rapidly, and biodegrade within 6 months. SUMMARY OF THE INVENTION [0007] The present invention is directed to medical devices, pharmaceutical and agricultural compositions, and seeds, each comprising a synthetic, bioabsorbable, biocompatible polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, the polymeric wax having a melting point less than about 70.degree. C., as determined by differential scanning calorimetry. BRIEF DESCRIPTION OF THE FIGURES [0008] FIG. 1 is a plot of sustained release of Risperidone from poly(monostearoyl glycerol-co-succinate) microparticles in vitro. [0009] FIG. 2 is a plot of sustained release of Risperidone Pamoate from poly(monostearoyl glycerol-co-succinate) microparticles in vitro. [0010] FIG. 3 is a plot of sustained release of Risperidone Pamoate from poly(monostearoyl glycerol-co-succinate) microparticles in vivo. [0011] FIG. 4 is a plot of sustained release of Risperidone from poly(monostearoyl glycerol-co-succinate) films in vitro. [0012] FIG. 5 is a plot of sustained release of Risperidone from poly(monostearoyl glycerol-co-succinate) cylinders in vitro. [0013] FIG. 6 is a plot of sustained release of Albumin from Poly(monostearoyl glycerol-co-succinate) in vitro. DETAILED DESCRIPTION OF THE INVENTION [0014] Alkyd polymers have been prepared by several known methods. For example, alkyd-type polymers were prepared by Van Bemmelen (J. Prakt. Chem., 69 (1856) 84) by condensing succinic anhydride with glycerol. In the "Fatty Acid" method (see Parkyn, et al. Polyesters (1967), Iliffe Books, London, Vol. 2 and Patton, In: Alkyd Resins Technology, Wiley-Interscience New York (1962)), a fatty acid, a polyol and an anhydride are mixed together and allowed to react. The "Fatty Acid-Monoglyceride" method includes a first step of esterifying the fatty acid with glycerol and, when the first reaction is complete, adding an acid anhydride. The reaction mixture then is heated and the polymerization reaction takes place. In the "Oil-Monoglyceride" method, an oil is reacted with glycerol to form a mixture of mono-, di-, and triglycerides. This mixture then is polymerized by reacting with an acid anhydride. [0015] The synthetic, bioabsorbable, biocompatible polymeric waxes utilized in the present invention are the reaction product of a polybasic acid or derivative thereof, a fatty acid, and a polyol, and may be classified as alkyd polyester waxes. As used herein, a wax is a solid, low-melting substance that is plastic when warm and, due to its relatively low molecular weight, is fluid when melted. Preferably, the polymeric waxes of the present invention are prepared by the polycondensation of a polybasic acid or derivative thereof and a monoglyceride, wherein the monoglyceride comprises reactive hydroxy groups and fatty acid groups. The expected hydrolysis byproducts are glycerol, dicarboxylic acid(s), and fatty acid(s), all of which are biocompatible. Preferably, the polymeric waxes utilized in the present invention will have a number average molecular weight between about 1,000 g/mole and about 100,000 g/mole, as determined by gel permeation chromatography. The polymeric waxes comprise an aliphatic polyester backbone with pendant fatty acid ester groups that crystallize rapidly, depending on the fatty acid chain length, and exhibit relatively low melting points, e.g. less than about 100.degree. C., preferably less than about 70.degree. C. More preferably, the melting point of the polymeric wax will be between about 25.degree. C. and about 70.degree. C. Typically, the polymeric waxes used in the present invention will be a solid at room temperature. [0016] Fatty acids used to prepare polymeric waxes utilized in the present invention may be saturated or unsaturated and may vary in length from C.sub.14 to C.sub.30. Examples of such fatty acids include, without limitation, stearic acid, palmitic acid, myrisitic acid, caproic acid, decanoic acid, lauric acid, linoleic acid and oleic acid. [0017] Polyols that can be used to prepare the polymeric waxes include, without limitation, glycols, polyglycerols, polyglycerol esters, glycerol, sugars and sugar alcohols. Glycerol is a preferred polyhydric alcohol due to its abundance and cost. [0018] Monoglycerides which may be used to prepare polymeric waxes utilized in the present invention include, without limitation, monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol, monooleoyl glycerol, and combinations thereof. Preferred monoglycerides include monostearoyl glycerol, monopalmitoyl glycerol and monomyrisitoyl glycerol. [0019] Polybasic acids that can be used include natural multifunctional carboxylic acids, such as succinic, glutaric, adipic, pimelic, suberic, and sebacic acids; hydroxy acids, such as diglycolic, malic, tartaric and citric acids; and unsaturated acids, such as fumaric and maleic acids. Polybasic acid derivatives include anhydrides, such as succinic anhydride, diglycolic anhydride, glutaric anhydride and maleic anhydride, mixed anhydrides, esters, activated esters and acid halides. The multifunctional carboxylic acids listed above are preferred. Continue reading about Compositions and medical devices utilizing bioabsorbable polymeric waxes... Full patent description for Compositions and medical devices utilizing bioabsorbable polymeric waxes Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Compositions and medical devices utilizing bioabsorbable polymeric waxes patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Compositions and medical devices utilizing bioabsorbable polymeric waxes or other areas of interest. ### Previous Patent Application: Abuse-resistant retortable packaging film having oxygen barrier layer containing blend of amorphous polyamide and semicrystalline polyamide Next Patent Application: Container with acid diffusion barrier and use thereof Industry Class: Stock material or miscellaneous articles ### FreshPatents.com Support Thank you for viewing the Compositions and medical devices utilizing bioabsorbable polymeric waxes patent info. IP-related news and info Results in 0.13204 seconds Other interesting Feshpatents.com categories: Accenture , Agouron Pharmaceuticals , Amgen , AT&T , Bausch & Lomb , Callaway Golf 174 |
 * Protect your Inventions * US Patent Office filing 
PATENT INFO |
|
