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12/15/05 - USPTO Class 514 |  60 views | #20050277585 | Prev - Next | About this Page  514 rss/xml feed  monitor keywords

Combinations of immunosupressive agents for the treatment or prevention of graft rejections

Title: Combinations of immunosupressive agents for the treatment or prevention of graft rejections


Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai, Cyclopeptides, Monocyclic

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20050277585, Combinations of immunosupressive agents for the treatment or prevention of graft rejections.


1-6. (canceled)

7. A Method of reducing early graft damage, improving early xenograft function or promoting long term survival of xenografts of a transgenic organ in human recipients comprising the steps of: (i) exposing body fluid removed from a human recipient with a xenoantigenic material or anti-human mono- or polyclonal antibodies or another antibody adsorbent, which is bound to a biocompatible solid support; (ii) reintroducing the treated body fluid into the human recipient, and (iii) treating the human recipient with a pharmaceutical composition comprising at least two immunosuppressant compounds selected from the group consisting of (a) IL-2 transcription inhibitors and (b) immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts.

8. A method for reducing early graft damage, improving early xenograft function or promoting long term survival of xenografts of an organ transgenic for hDAF in human recipients comprising the steps of: (i) exposing body fluid removed from a human recipient with a xenoantigenic material or anti-human mono- or polyclonal antibodies or another antibody adsorbent, which is bound to a biocompatible solid support; (ii) reintroducing the treated body fluid into the human recipient, and (iii) treating the human recipient with a pharmaceutical composition comprising at least two immunosuppressant compounds selected from the group consisting of (a) IL-2 transcription inhibitors and (b) immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts.

9. The method according to claim 7 wherein the steps (i) and (ii) are conducted postoperatively and in parallel with treatment with the pharmaceutical composition.

Brief Patent Description - Full Patent Description - Patent Claims

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