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Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
11/13/2014 > 13 patent applications in 9 patent subcategories.

20140336355 - Ion-exchanger material with high salt-tolerance: The present invention relates to a crosslinked sulphonated polymer or a crosslinked sulphonated polymer coated with a crosslinked polymer containing amino groups for use as an ion exchanger material of high salt tolerance for separating off macromolecules from a solution which originates from a biological source.... Agent: Instraction Gmbh

20140336356 - Peptide agonists of glp-1 activity: Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose... Agent: Zealand Pharma A/s

20140336357 - Microbial nanowires: The application describes electrically conductive nanowires, as well as genetically and/or chemically modified nanowires with modified conductive, adhesive and/or coupling properties.... Agent:

20140336358 - Methods and compositions for tumor vaccination and therapy: The present invention relates to peptide vaccines, pharmaceutical compositions thereof, and associated methodologies that promote the immune-mediated regression of tumors expressing an onconeural antigen, e.g. a cdr-2 antigen, HuD antigen. The cancer peptide vaccines of the present invention are antigenic peptides capable of being faithfully presented on the MHC I... Agent: Rockefeller University (the)

20140336359 - Synthetic peptides for treatment of bacterial infections: Disclosed are peptides and methods for the treatment of bacterial infections and associated inflammation. Effective doses and treatment protocols are disclosed.... Agent:

20140336363 - Antibodies against human csf-1r and uses thereof: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.... Agent: Hoffmann-la Roche Inc.

20140336361 - Assembly of bispecific antibodies: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins... Agent: Genentech, Inc.

20140336362 - Avian derived antibodies: The invention is drawn to a composition comprising an isolated mixture of cytotoxic anti-CD20 antibody molecules produces in a transgenic avian. The antibody molecules have a heavy chain and a light chain and exhibit an increased level of antibody-dependent cell-mediated cytotoxicity (ADCC) as compared to that of anti-CD20 antibody molecules... Agent: Synageva Biopharma Corp.

20140336360 - Tyrosine, serine and threonine phosphorylation sites: The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent:

20140336364 - Monoclonal antibody against interferon-gamma (ifn-gamma) inducing factor (ifig, il-18): A protein which induces the IFN-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The... Agent:

20140336365 - Cdr regions of monoclonal antibody that antagonize sphinogosine 1-phosphate and related methods: Materials and method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of... Agent:

20140336366 - Bioconjugate vaccines made in prokaryotic cells: Provided herein are prokaryotic cells capable of producing bioconjugates comprising glycosylated proteins. Also provided herein are compositions comprising such bioconjugates and/or comprising the saccharide moieties of such bioconjugates, as well as methods of vaccinating subjects using such compositions.... Agent: Glycovaxyn Ag

20140336367 - Recombinant nel-like (nell) protein production: The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a non-insect secretory signal peptide.... Agent: The Regents Of The University Of California

  
11/06/2014 > 11 patent applications in 10 patent subcategories.

20140329989 - Preparation of micafungin intermediates: The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, preferably micafungin (MICA) or a salt thereof.... Agent: Sandoz Ag

20140329990 - Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom: The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer... Agent: Nektar Therapeutics

20140329991 - Isolation of phosphoproteins, glycoproteins and fragments thereof: The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for many types of biological samples, including... Agent:

20140329992 - Porous tissue scaffolds: A method for forming a porous tissue material.... Agent: Fujifilm Corporation

20140329993 - Foam-formed collagen strand: Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen... Agent:

20140329994 - Branched polymers: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a... Agent:

20140329995 - Affinity chromatography matrix: The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein Z or the C domain of protein A or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for... Agent: Ge Healthcare Bio-sciences Ab

20140329997 - Acoustic bioreactor processes: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the... Agent:

20140329996 - Tissue specific expression of antibodies in chickens: Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds... Agent: Synageva Biopharma Corp.

20140329998 - Methods for making saccharide-protein glycoconjugates: The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier... Agent: Novartis Ag

20140329999 - Method for working up an aqueous lignin containing solution: A method for working up an aqueous, alkaline-alcoholic and lignin containing solution via nanofiltration, wherein a permeate and a retentate are obtained, which permeate is an aqueous, lignin-starved solution and which retentate is an aqueous lignin-enriched solution... Agent: Annikki Gmbh

  
10/30/2014 > 16 patent applications in 10 patent subcategories.

20140323687 - Method for protein isolation in anoxic conditions: The present invention relates to a method for the isolation of proteins that comprise disulfide-bonds in their native conformation. Essentially, a method of the present makes the use of reducing agents such as β-mercaptoethanol or dithiothreitol in protein isolation methods obsolete. A method of the present invention is particularly suitable... Agent:

20140323688 - Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The... Agent:

20140323689 - Process for the preparation of a viral protease inhibitor and intermediates thereof: Process for the preparation of a viral protease inhibitor and intermediates useful in its preparation.... Agent: Dipharma Francis S.r.i.

20140323690 - Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:... Agent:

20140323693 - Antibodies to non-functional p2x7 receptor: The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between functional and non-functional p2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.... Agent: Biosceptre International Limited

20140323692 - Development of sensitive fret sensors and methods of using the same: Intramolecular biosensors are disclosed, including PBP-based biosensors, comprising a ligand binding domain fused to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding ligand. At least one of the donor and fluorescent moieties may be internally fused to the biosensor such that both... Agent: Carnegie Institution Of Washington

20140323691 - Isopeptide bond formation in bacillus species and uses thereof: A mechanism for a unique isopeptide bond formation between polypeptides is disclosed as well as sequence motifs used in such bond formation and methods of using such sequence motifs.... Agent:

20140323694 - Multiphase porous flow reactors and methods of using same: PFRs for running multiphasic processes are disclosed. The PFRs are single or multi-chamber devices having at least three types of regions (a liquid-contacting region, a gas-contacting region and a liquid-collection region), and a porous substrate providing fluid communication at least between the liquid-contacting and gas-contacting regions. Removal of liquid from... Agent:

20140323695 - Protein purification method: A method for manufacturing an antibody formulation in which DNA contaminants are removed by binding the antibody to a protein-A or probtin-G affinity column and eluting the antibody with an acidic eluting solution, preferably of low conductivity.... Agent:

20140323697 - Media for affinity chromatography: The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same.... Agent:

20140323696 - Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.... Agent: The Rockefeller University

20140323698 - Protein purification using bis-tris buffer: The invention provides a two-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution.... Agent:

20140323699 - Method of detecting cancer based on glycan biomarkers: The present invention provides a method for labeling or detecting a protein with certain glycosyl groups. The methods are particularly useful for detecting cancer cells comprising the detected glycosyl groups. The present invention further provides labeling agents and detection agents, labeled proteins and mixtures, and kits and arrays thereof.... Agent: California Institute Of Technology

20140323700 - Recombinant n-glycosylated proteins from procaryotic cells: The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells... Agent: Eth Z&#xdc Rich

20140323701 - Biologically active peptidomimetic macrocycles: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.... Agent: Aileron Therapeutics, Inc.

20140323702 - Method for producing a protein hydrolysate: The invention relates to a method for producing a protein hydrolysate. In particular, the invention relates to a method for producing a keratin hydrolysate. A method for producing a protein hydrolysate is proposed, comprising: providing a protein source in the form of an aqueous suspension; adding a complexing agent to... Agent:

  
10/23/2014 > 14 patent applications in 10 patent subcategories.

20140316104 - Cyclosporin derivatives: The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with... Agent: Max-planck-gusellschaft Zur F&#xd6 Rderung Der Wissenschaften E.v.

20140316106 - Integrin-blocking polypeptides and uses thereof: A series of integrin blockers that present strong angiogenesis inhibiting performance, high integrin affinity and integrin-bonding capacity is provided. This series of integrin blockers can be adopted in treatment of solid tumors and rheumatoid arthritis. Specifically, said series of integrin blockers include polypeptide I, polypeptide II and polypeptide III (see... Agent:

20140316105 - Method for modification of organic molecules: The present invention is directed to a method of alkylating a thiol group (R—S—H) or seleno group (R—Se—H) in a target molecule wherein the method comprises: reacting a target molecule comprising at least one thiol group with a compound of formula (I) or (II): wherein R is an acetyl group... Agent: Nanyang Technological University

20140316107 - Cyclin based inhibitors of cdk2 and cdk4: Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of... Agent:

20140316108 - Protein chromatography matrices with hydrophilic copolymer coatings: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of... Agent:

20140316109 - Activated collagen scaffold materials and their special fused active restoration factors: Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding... Agent:

20140316110 - Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The... Agent:

20140316111 - Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyanoimidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The... Agent:

20140316112 - Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides: This invention is directed to the use of a chorionic gonadotrophin carboxy terminal peptide (CTP) or fragments thereof for modifying a polypeptide or a fragment thereof in order to increase the hydrodynamic volume of the polypeptide or fragment thereof.... Agent:

20140316114 - Method for preparing active form of tnfr-fc fusion protein: The present invention relates to a method for separating and preparing a TNFR-Fc fusion protein using hydrophobic interaction chromatography (HIC). More particularly, the present invention relates to a method for separating and preparing a highly pure active protein from clipped proteins due to displacement effect by adjusting the conductivity of... Agent: Hanwha Chemical Corporation

20140316113 - Method for the humanization of antibodies and humanized antibodies thereby obtained: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.... Agent: Scuola Internazionale Superiore Di Studi Avanzati

20140316115 - Method of antibody purification: The present invention relates to a method for preparing a population of antibodies to have high purity and high quality by removing antibody isoforms and impurities through the use of a cation exchange column, a hydrophobic interaction column, and an anion exchange column successively, without using a protein A column;... Agent: Hanwha Chemical Corporation

20140316116 - Methods for screening for binding partners of g-protein coupled receptors: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test... Agent: Heptares Therapeutics Limited

20140316117 - Polymers and plastics derived from animal proteins: The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and... Agent: The Governors Of The University Of Alberta

Previous industry: Synthetic resins or natural rubbers -- part of the class 520 series
Next industry: Organic compounds -- part of the class -570 series


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