Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions

20080108787 - Purification of insulin-like material by reverse phase chromatography: This invention describes processes for purification of insulin or insulin-like material by reverse phase chromatography by using polystyrenic resins as the chromatographic materials. in particular the present invention describes processes for the purification of a particular insulin-like material from chemically and structurally similar contaminants.... Agent: Bio Intellectual Property Services (bio Ips) Llc

20080108789 - Dna & protein binding miniature proteins: The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.... Agent: Wolf Greenfield & Sacks, P.c.

20080108788 - Recombinant c140 receptor, it's agonists and antagonists, and nucleic acids encoding the receptor: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080108790 - S-alkyl-sulphenyl protection groups in solid-phase synthesis: A novel method for on-resin formation of disulfide-borne cyclization of peptides is devised.... Agent: Nixon & Vanderhye, Pc

20080108792 - Human interferon molecules and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108791 - Modified human interferon polypeptides and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108793 - Novel purified fabi polypeptides from fransicella tularensis: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.... Agent: Goodwin Procter LLP Patent Administrator

20080108794 - Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer: Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The different targets include (i) proinflammatory effectors of the innate immune system, (ii) coagulation factors, and (iii) targets specifically associated with an inflammatory or immune-dysregulatory disorder, with a... Agent: Rossi, Kimms & Mcdowell LLP.

20080108795 - Reagents for the detection of protein phosphorylation in egfr-signaling pathways: The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for... Agent: Simona Levi-minzi, Ph.d. General Counsel

20080108796 - Human il-1 epsilon dna and polypeptides: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and... Agent: Immunex Corporation Law Department

20080108797 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108798 - Selection of fibronectin scaffolds using nucleic acid-protein fusions: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.... Agent: Ropes & Gray LLP

20080103290 - Process for purifying glycopertide phosphonate derivatives: Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, eluting the resin with an aqueous solution, and isolating... Agent: Theravance, Inc.

20080103291 - Dna molecules encoding ligand gated ion channels from dermacentor variabilis: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel... Agent: Judy Jarecki-black, Ph.d.,j.d Merial Ltd.

20080103292 - Glycopeptide derivatives and pharmaceutical compositions containing the same: e

20080103293 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080103294 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080097078 - Glycopeptide antibiotic monomer derivatives: Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080097079 - Cyclization of a peptide: An improved method for cyclization of peptide (H)-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp(NH2) by cystine formation is devised.... Agent: Nixon & Vanderhye, PC

20080097081 - Method of treating apoptosis and compositions thereof: Disclosed herein are novel polypeptides and the nucleic acid sequences that encode them. Also disclosed are antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20080097083 - Modified human four helical bundle polypeptides and their uses: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080097082 - Novel polypeptide hormone phosphatonin: The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this... Agent: Bozicevic, Field & Francis LLP

20080097080 - Protein structure: Protein structures 1 repeating regularly in one, two or three dimensions comprise protein protomers 2 which each comprise at least two monomers 5, 6 genetically fused together. The monomers 5, 6 are monomers of respective oligomer assemblies 3, 4 into which the monomers are assembled to assembly of the protein... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080097084 - Rho antibody and tag to purify cell surface proteins: A process for the expression and purification of membrane associated proteins is provided. A process for the expression and purification of membrane proteins such as G-protein coupled receptors is provided. A hybrid polypeptide is constructed from a protein of interest and a peptide tag from the amino-terminus extracellular domain of... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property

20080090993 - Purified mammalian cytokines; related reagents and methods: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080090994 - Novel antigen constructs useful in the detection and differentiation of antibodies to hiv: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences... Agent: Robert Deberardine Abbott Laboratories

20080090995 - Liquid chromatography method: The present invention relates to a method for the non-magnetic purification of cellular components from a crude cell lysate by continuous liquid chromatography, which method comprises lysis of cells in a vessel to provide a crude cell lysate; passing the crude cell lysate so obtained, without any intermediate clarification, over... Agent: Ge Healthcare Bio-sciences Corp. Patent Department