|Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof patents - Monitor Patents|
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Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereofBelow are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 09/04/2014 > 9 patent applications in 8 patent subcategories.
20140249292 - Modulation of structured polypeptide specificity: The invention describes a method for selecting a polypeptide ligand having a desired level of specificity for a target, wherein the polypeptide ligand comprises a polypeptide comprising at least three reactive groups, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the reactive... Agent: Bicycle Therapeutics Limited
20140249293 - Absent and rare peptides and therapeutic uses thereof: The present invention relates to methods for searching and identifying absent and rare peptide sequences from public databases and their uses in the treatment of pathological diseases. One embodiment of the present invention provides a method that includes: a) storing, in a memory or storage of a computing device, a... Agent: Boise State University
20140249294 - Process for production of peptide thioester: A process for chemically converting a peptide chain into a peptide thioester includes, when a —C(═X)—R1 group is introduced to the thiol group of the cysteine residue and then the resulting peptide is reacted with a compound having a leaving group represented by the formula: —NH—C(═Y)NHR3 in an organic solvent,... Agent: Glytech, Inc.
20140249295 - Light-inducible system for regulating protein stability: Disclosed herein are a light-inducible system and method for rapidly and reversibly modulating protein stability and function. This system and method employs conditionally stable protein domains that regulate the degradation of a fusion protein depending upon the presence or absence of a particular light source.... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20140249297 - Antibodies with modified isoelectric points: The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.... Agent: Xencor, Inc.
20140249296 - Using sortases to install click chemistry handles for protein ligation: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed... Agent: Whitehead Institute For Biomedical Research
20140249298 - Anti-human equilibrative nucleoside transporter 1 (hent1) antibodies adn methods of use thereof: This invention provides monoclonal antibodies that recognize hENT1. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and/or prophylactic in disorders associated with aberrant hENT1 expression and/or activity.... Agent:
20140249299 - Hybrid polypeptides with selectable properties: The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are... Agent: Amylin Pharmaceuticals, LLC
20140249300 - Metal catalyzed oxidation of lignin and related compounds: Disclosed are methods for the benzylic oxidation of the lignin and related compounds. The methods include contacting lignin with a mixture containing manganese and iron, in the presence of oxygen to produce a carboxylic acid from lignin or a related compound. In some embodiments, the mixture includes cobalt.... Agent: University Of Tennessee Research Foundation08/28/2014 > 14 patent applications in 9 patent subcategories.
20140243498 - Method for purification of cleaved pro-insulin: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.... Agent:
20140243500 - Calibration and normalization systems and methods for radiopharmaceutical synthesizers: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).... Agent:
20140243499 - Peptide derivatives and use thereof as carriers for molecules in the form of conjugates: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise... Agent: Universite D'aix Marseille
20140243501 - Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments: The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of... Agent: Nanjing Yoko Pharmaceutical Co., Ltd. [cn/cn]
20140243506 - Antagonists of il17c for the treatment of inflammatory disorders: The present invention provides antagonists of IL17C for use in the treatment of an inflammatory disorder.... Agent:
20140243504 - Antibodies comprising chimeric constant domains: Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems,... Agent: Regeneron Pharmaceuticals, Inc.
20140243502 - Anticoagulation agent and uses thereof: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe... Agent: Baker Idi Heart And Diabetes Institute Holdings Limited
20140243505 - Bispecific antibody: Provided are bispecific antibodies comprised of a single-chain unit having specificity to an immune cell and a monovalent unit having specificity to a tumor cell or a microorganism. The single-chain unit includes a single-chain variable fragment (scFv) fused to an Fc fragment and the monovalent unit includes a light chain... Agent: Wuhan Yzy Biopharma Co., Ltd.
20140243503 - Fgf21 mutants and uses thereof: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.... Agent: Amgen Inc.
20140243507 - Method of screening antibodies with high antigen selectivity: Provided is a method of screening a target-specific antibody for an antigen that undergoes structural change in a particular physiological condition.... Agent: Samsung Electronics Co., Ltd.
20140243508 - Method for the purification of antibodies: A method for the purification of immunoglobulins by ion exchange chromatography is described. The chromatographic method uses a weak ion exchange resin and a single step elution process for the purification of an immunoglobulin. Additionally a method for the determination of the salt concentration for the single step elution of... Agent: Hoffmann-la Roche Inc.
20140243509 - Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing: Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance,... Agent:
20140243510 - Methods for purifying erythropoietin analogs having lower isoelectric point: The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an N-linked sugar chain with high purity. In accordance with the present invention, the erythropoietin analog having an isoelectric point below 4, which is an isoform having more sialic... Agent: Chong Kun Dang Pharmaceutical Corp.
20140243511 - Functionalized lignin and method of producing the same: In this study, commercially available softwood lignin was esterified with tall oil fatty acid (TOFA) and tested as barrier material in fiber-based packaging material. The modified lignin samples were applied with a bar coater forming an even coating on the paperboard substrate. A significant decrease in WVTR and OTR value... Agent:08/21/2014 > 20 patent applications in 15 patent subcategories.
20140235819 - Deuterated cyclosporine analogs and methods of making the same: Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution... Agent: Aurinia Pharmaceuticals, Inc.
20140235820 - Methods and compositions for modulating the wnt pathway: The invention provides methods and compositions for modulating the Wnt signaling pathway, in particular by interfering with binding of Dkk1 or SOST with LRP5 and/or LRP6.... Agent: Genentech, Inc.
20140235821 - Novel phosphatidylinositol-3-kinase inhibitor and pharmaceutical composition: A substance contains a phosphatidylinositol-3-kinase (PI3K) inhibitor including a depsipeptide-class compound represented by formula (1), or a physiologically acceptable salt thereof that combines a PI3K inhibitory effect and an HDAC inhibitory effect to provide an anti-cancer pharmaceutical composition for the treatment of an intractable cancer.... Agent: Tohoku University
20140235822 - Method for producing peptide: The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group... Agent: Glytech, Inc.
20140235823 - Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same: The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein. The present invention also provides a fusion protein comprising a single-stranded DNA binding protein and an interest protein or... Agent:
20140235824 - Method to wash greasy wool, a method to separate lanolin from the said greasy wool, wool and lanolin obtainable by these methods: A method to wash wool containing lanolin and impurities includes the steps of providing a volume of an aqueous liquid at a temperature below a melting temperature of the lanolin, soaking the wool in the volume of the liquid, creating air bubbles in the liquid and allowing the air bubbles... Agent:
20140235825 - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits... Agent: Tenaxis Medical, Inc.
20140235826 - Optically-based stimulation of target cells and modifications thereto: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20140235830 - Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9): Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen... Agent: Amgen, Inc.
20140235829 - Compositions and methods for regulation of tumor necrosis factor-alpha: The present invention relates to compositions and methods relating to an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.... Agent:
20140235828 - Gram-positive bacteria specific binding compounds: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.... Agent: Genentech, Inc.
20140235827 - Mouse anti-aggrus monoclonal antibodies: The present invention provides a monoclonal antibody or a functional fragment thereof, capable of recognizing Aggrus epitope comprising an amino-acid sequence represented by a sequence ID 1, 3, or 4, and the monoclonal antibody or the functional fragment thereof produced from a hybridoma with deposit ID of FERM BP-11446, FERM... Agent: Japanese Foundation For Cancer Research
20140235831 - Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9): Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen... Agent: Amgen, Inc.
20140235832 - Rank ligand polypeptides: Described herein are kits for use in detecting RANKL polypeptides.... Agent: Immunex Corporation
20140235833 - Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same: The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors... Agent: Fujita Health University
20140235834 - Method for preparing polybiotinylated compounds: The present invention relates to compounds having the formula (I) and their use in clinical and industrial diagnosis.... Agent: Biomé Rieux
20140235835 - Calicheamicin derivative-carrier conjugates: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates,... Agent: Wyeth Holdings LLC
20140235836 - Immunologic constructs and methods: The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation... Agent: Vaxinnate Corporation
20140235837 - Method for purifying protein: The present invention provides a method for purifying a protein, comprising an adsorption step and an elution step, wherein in the elution step, at least one eluent is passed in the opposite direction with respect to the direction of the passage of a stock solution containing an adsorption target protein,... Agent: Asahi Kasei Chemicals Corporation
20140235838 - Selective aerobic alcohol oxidation method for conversion of lignin into simple aromatic compounds: Described is a method to oxidize lignin or lignin sub-units. The method includes oxidation of secondary benzylic alcohol in the lignin or lignin sub-unit to a corresponding ketone in the presence of unprotected primarily aliphatic alcohol in the lignin or lignin sub-unit. The optimal catalyst system consists of HNO3 in... Agent: Wisconsin Alumni Research Foundation08/14/2014 > 12 patent applications in 11 patent subcategories.
20140228539 - Separation of acetylated proteins from unacetylated proteins: The invention relates to a process for separating acetylated proteins from unacetylated proteins. In particular, the invention relates to a process of using multimodal chromatography to separate acetylated proteins from unacetylated proteins. In the prior art, multimodal chromatography is used to isolate antibodies. The invention found that multimodal chromatography can... Agent: La Jolla Biologics, Inc.
20140228540 - Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods: The present invention relates to TIMP-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.... Agent: Amgen Inc.
20140228541 - Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules: The present application discloses compositions and methods of synthesis and use of 18F- or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex... Agent: Immunomedics, Inc.
20140228542 - Method for producing peptide fractions and use thereof: The invention relates to a method for producing enriched peptide fractions from protein-containing raw materials, in which protein hydrolysates are separated using chromatography, according to the physiochemical properties thereof, by means of stationary phases with an aqueous solution as an elution agent.... Agent:
20140228543 - Modified and derivatized ß-glucan compounds, compositions, and methods: Modified and/or derivativized β-glucans with an enhanced capacity to modulate human immune response as compared to the parent, unmodified and/or underivatized β-glucans are demonstrated.... Agent:
20140228545 - Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9): Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen... Agent: Amgen, Inc.
20140228544 - Constructs and libraries comprising antibody surrogate light chain sequences: The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.... Agent: Sea Lane Biotechnologies LLC
20140228546 - Serum albumin binding proteins: The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise... Agent: Ablynx N.v.
20140228547 - Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9): Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen... Agent: Amgen, Inc.
20140228548 - Viral clearance methods: The invention provides methods for separating a polypeptide of interest (such as an antibody) from a virus. In some embodiments, the methods involve eluting the polypeptide of interest from a Protein A resin with an elution buffer have a particular range of conductivity values that minimizes the amount of virus... Agent: Human Genome Sciences
20140228549 - Process for separation/purification of biomolecules: A method to at least one of separate and purify biomolecules via an aqueous two-phase extraction includes providing the biomolecules in a first aqueous phase, providing a porous material comprising pores, providing a second aqueous phase at least in the pores of the porous material, and, at least one of... Agent: Technische Universitaet Dortmund
20140228550 - Process for obtaining proteins from a native substance mixture: A process is provided for obtaining proteins from native substance mixtures, wherein a native substance mixture is first finely disintegrated and optionally processed to form a flowable slurry (I) by adding liquid. The process includes the following steps: (i) setting the pH value of the slurry (I) in an alkaline... Agent: Gea Mechanical Equipment GmbhPrevious industry: Synthetic resins or natural rubbers -- part of the class 520 series
Next industry: Organic compounds -- part of the class -570 series
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