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Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof August inventions list 08/09

20090215981 - Glp-1 pegylated compounds: The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by... Agent: Eli Lilly & Company

20090215982 - Glycopeptide derivatives and pharmaceutical compositions containing the same: e

20090215983 - Compounds and methods for inhibiting hepatitis c virus replication: The inventors have discovered that an ATPase-deficient dominant-negative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal structure of a multi-enzyme NS3 complex on a DNA substrate is also provided. The inventors have tested... Agent: Hugh Mctavish Mctavish Patent Firm

20090215984 - Conversion of apoptotic proteins: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with... Agent: Knobbe Martens Olson & Bear LLP

20090215985 - Differentially protected orthogonal lanthionine technology: The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090215986 - Solution synthesis of peptide cell growth stimulators: A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale.... Agent: Philip S. Johnson Johnson & Johnson

20090215987 - Peptide amidation process: The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2-X3, wherein X2 is any amino... Agent: Campbell Nelson Whipps, Llc

20090215988 - Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution: PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation period for a drug-PEG conjugate, followed by hydrolytic breakdown of the conjugate and release... Agent: Nektar Therapeutics

20090215989 - Heterologous protein production using the twin arginine translocation pathway: Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, are simple ways to express, secrete and purify correctly folded heterologous proteins on a large scale using host microorganisms, such as, Streptomyces and the... Agent: Montgomery, Mccracken, Walker & Rhoads, LLP

20090215990 - Method and system for production of zein and/or xanthophylls using chromatography: Methods and systems for obtaining zein and/or xanthophylls in highly pure form. Zein is first extracted from corn using aqueous ethanol. Suspended corn solids are separated, and the resulting extract is purified in a single size-exclusion chromatography step to separate impurities and produce substantially purified zein. The chromatography step may... Agent: Greer, Burns & Crain

20090215991 - Optimized fc variants and methods for their generation: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.... Agent: Morgan, Lewis & Bockius, LLP

20090215992 - Dual variable domain immunoglobulin and uses thereof: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.... Agent: Yankwich & Associates, P.c. (and Abbott Bioresearch Center)

20090215993 - Mycophenolic acid immunogens and antibodies: Described are immunogenic compounds useful for generation of antibodies which are highly specific for mycophenolic acid which do not react or have substantially no cross-reactivity with the glucuronide metabolites of mycophenolic acid, especially the acyl-glucuronide metabolite.... Agent: Roche Diagnostics Operations Inc.

20090215994 - Novel centromeric protein shugoshin: The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis... Agent: Locke Lord Bissell & Liddell LLP Attn: Ip Docketing

20090215995 - B-7 related nucleic acids and polypeptides useful for immunomodulation: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated... Agent: Louis J. Wille Bristol-myers Squibb Company

20090215996 - Crosslinked polymers with amine binding groups: Crosslinked polymeric materials are described that contain pendant amine capture groups. The amine capture groups include N-sulfonyldicarboximide groups that can react with amine-containing materials by a ring opening reaction. Reaction mixtures used to prepare the crosslinked polymeric materials, articles containing the crosslinked polymeric materials, methods of making articles, and methods... Agent: 3m Innovative Properties Company

20090215997 - Separation method: A method of separating a fluorescent protein from a sample containing a plurality of proteins containing the fluorescent protein is provided. The method comprising: preparing a sample solution by adding the sample to a liquid; preparing an adsorption apparatus having a filling space for filling an adsorbent having a surface,... Agent: Greenblum & Bernstein, P.L.C

20090215998 - Devices and methods for high-pressure refolding of proteins: Disclosed are devices for holding samples, particularly liquid samples, during high-pressure treatment. The devices enable a variety of functions, such as high-throughput screening of samples in multi-compartment device embodiments, and adjustment of solution conditions during high-pressure treatment. The devices are designed to maintain integrity during the high-pressure conditions, and are... Agent: Morrison & Foerster LLP

20090209728 - Peptides that increase collagen or hyaluronic acid production: The present invention relates to a novel peptide having a specified amino acid sequence or its derivative, or a salt thereof. Further, the present invention relates to a composition containing the novel peptide or the like, a method of utilizing the novel peptide or the like, use of the novel... Agent: Birch Stewart Kolasch & Birch

20090209731 - Heteromeric taste receptors: Heteromeric taste receptors are provided. These receptors comprise a first polypeptide containing extracellular domains and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R1 polypeptides and the transmembrane domains are at least 95% identical to the corresponding transmembrane domains of the... Agent: Hunton & Williams LLP Intellectual Property Department

20090209730 - Method for gene transfer into target cells with retrovirus: t

20090209729 - Recombinant chemokine-antigen vaccine: A recombinant gene sequence that comprises human SLC gene, antigen gene, and IgG1-Fc fragment gene, wherein the SLC gene is linked upstream to the antigen gene, and the IgG1-Fc fragment is linked downstream to the antigen gene. This invention also relates to the application of the recombinant gene sequence in... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20090209732 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.

20090209733 - Therapeutic agent for rheumatoid arthritis: A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid arthritis, which comprises an antibody that binds to a hepatocyte growth factor receptor as an active ingredient.... Agent: Knobbe Martens Olson & Bear LLP

20090209734 - Peptidyl prodrugs and linkers and stabilizers useful therefor: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides... Agent: Medarex C/o Darby & Darby P.C.

20090209735 - Affinity separation by partition enhancing material conjugated biomolecules in aqueous two-phase extraction system: The present invention relates to a method for separating a material that has affinity to an antibody by using a protein-antibody conjugate with modified partition characteristics, more precisely a method for affinity separation to separate a material specifically binds to an antibody, in which an antibody is conjugated to a... Agent: Lucas & Mercanti, LLP

20090209736 - Multicolumn sequential separation process: The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow... Agent: Marsh, Fischmann & Breyfogle LLP

20090209737 - Use of denaturing agents during affinity capture: A method for affinity capturing target molecules is disclosed, comprising obtaining a sample comprising a target molecule; and, in the presence of a denaturing agent; affinity capturing the target molecule with a single chain affinity molecule or antigen binding portion thereof that specifically binds the target molecule, wherein the affinity... Agent: Leydig Voit & Mayer, Ltd

20090209738 - Method for separating keratinous proteins from materials: A process for separating keratinous proteins from a keratin-containing material, the process comprising the steps of: subjecting the keratin-containing material to reduction in a liquid medium to solubilise the keratinous proteins under conditions that minimise hydrolysis of the keratinous proteins, to yield a solution of keratinous proteins and undissolved solids;... Agent: Quarles & Brady LLP

20090209739 - Method for separating and recovering lignin derivatives: An object of the present invention is to provide a technique for separation/collection of a lignin derivative which is useful for the separation of a lignin derivative having a 1,1-diphenylpropane unit and/or a unit derived from the 1,1-diphenylpropane unit from a mixture system containing the lignin derivative. In the Present... Agent: Oliff & Berridge, PLC

20090203877 - X-ray-dense conjugate: The present invention relates to an X-ray dense conjugate, the use of the conjugate for producing a diagnostic and therapeutic composition, a pharmaceutical and/or diagnostic composition, which comprises said conjugate, a method for the diagnostic and/or analytical treatment of biological material or a living being, and a method for the... Agent: Klarquist Sparkman, LLP

20090203878 - Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine... Agent: Klarquist Sparkman, LLP

20090203879 - Activated labeling reagents and methods for preparing and using the same: The present invention relates in general to labeling reagents useful for labeling biomolecules. In particular, the invention provides activated labeling reagents, methods of preparing the same, methods of using the labeled reagents for synthesizing a labeled biomolecule, kits that include reagents for a labeling a biomolecule and kits containing for... Agent: Winston & Strawn LLP Patent Department

20090203881 - Polymyxin b analogs for lps detoxification: The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as polymyxin B does. The dimeric structure is maintained by a pair of disulphide bonds involving the... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090203880 - Production of canola protein: A canola protein isolate having a protein content of at least about 90 wt % (N×6.25), preferably at least about 100 wt %, and consisting predominantly of the 2S protein and substantially free from the 7S and 12S proteins is prepared. In one aspect, canola oil seed meal is extracted... Agent: Sim & Mcburney

20090203885 - Astrocyte modulated genes and uses thereof: The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs)... Agent: Baker Botts L.L.P.

20090203884 - Chimeric hiv fusion proteins as vaccines: A chimeric fusion protein useful as an immunogen for inducing HIV antigen-specific immune responses contains a first polypeptidyl region and a second polypeptidyl region. The first polypeptidyl region includes a Pseudomonas Exotoxin A (PE) binding domain and a PE translocation domain. The second polypeptidyl region includes (i) a first peptidyl... Agent: Ipc Intellectual Property Connections, Inc.

20090203883 - Mussel bioadhesive: The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel MGFP-3A MUTANT (Mytilus galloprovincialis foot protein type-3A MUTANT) protein and a recombinant protein that is a hybrid of MGFP-3A MUTANT, FP (Foot Protein)-1 and MGFP-5 (Mytilus galloprovincialis foot protein type-5). According to the... Agent: LexyoumeIPGroup, LLC

20090203882 - Novel microbial enzymes and their use: Extracellular tyrosinases obtainable from Trichoderma spp. and methods for producing them by recombinant technology. The enzymes are particularly useful in cross-linking food proteins.... Agent: Young & Thompson

20090203886 - Humanized anti cd20 monoclonal antibody: The present invention provides a humanized anti human CD20 monoclonal antibody, selection criteria therefor, humanized antibodies selected using that criteria and showing biological characteristics suitable for use as pharmaceuticals.... Agent: Nixon Peabody, LLP

20090203887 - Novel centromeric protein shugoshin: The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis... Agent: Locke Lord Bissell & Liddell LLP Attn:IPDocketing

20090203888 - Isolated photoprotein aqdecay, and its use: The invention relates to the photoprotein AQdecay, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein AQdecay.... Agent: Barbara A. Shimei Director, Patents & Licensing

20090203877 - X-ray-dense conjugate: The present invention relates to an X-ray dense conjugate, the use of the conjugate for producing a diagnostic and therapeutic composition, a pharmaceutical and/or diagnostic composition, which comprises said conjugate, a method for the diagnostic and/or analytical treatment of biological material or a living being, and a method for the... Agent: Klarquist Sparkman, LLP

20090203878 - Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine... Agent: Klarquist Sparkman, LLP

20090203879 - Activated labeling reagents and methods for preparing and using the same: The present invention relates in general to labeling reagents useful for labeling biomolecules. In particular, the invention provides activated labeling reagents, methods of preparing the same, methods of using the labeled reagents for synthesizing a labeled biomolecule, kits that include reagents for a labeling a biomolecule and kits containing for... Agent: Winston & Strawn LLP Patent Department

20090203881 - Polymyxin b analogs for lps detoxification: The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as polymyxin B does. The dimeric structure is maintained by a pair of disulphide bonds involving the... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090203880 - Production of canola protein: A canola protein isolate having a protein content of at least about 90 wt % (N×6.25), preferably at least about 100 wt %, and consisting predominantly of the 2S protein and substantially free from the 7S and 12S proteins is prepared. In one aspect, canola oil seed meal is extracted... Agent: Sim & Mcburney

20090203885 - Astrocyte modulated genes and uses thereof: The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs)... Agent: Baker Botts L.L.P.

20090203884 - Chimeric hiv fusion proteins as vaccines: A chimeric fusion protein useful as an immunogen for inducing HIV antigen-specific immune responses contains a first polypeptidyl region and a second polypeptidyl region. The first polypeptidyl region includes a Pseudomonas Exotoxin A (PE) binding domain and a PE translocation domain. The second polypeptidyl region includes (i) a first peptidyl... Agent: Ipc Intellectual Property Connections, Inc.

20090203883 - Mussel bioadhesive: The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel MGFP-3A MUTANT (Mytilus galloprovincialis foot protein type-3A MUTANT) protein and a recombinant protein that is a hybrid of MGFP-3A MUTANT, FP (Foot Protein)-1 and MGFP-5 (Mytilus galloprovincialis foot protein type-5). According to the... Agent: LexyoumeIPGroup, LLC

20090203882 - Novel microbial enzymes and their use: Extracellular tyrosinases obtainable from Trichoderma spp. and methods for producing them by recombinant technology. The enzymes are particularly useful in cross-linking food proteins.... Agent: Young & Thompson

20090203886 - Humanized anti cd20 monoclonal antibody: The present invention provides a humanized anti human CD20 monoclonal antibody, selection criteria therefor, humanized antibodies selected using that criteria and showing biological characteristics suitable for use as pharmaceuticals.... Agent: Nixon Peabody, LLP

20090203887 - Novel centromeric protein shugoshin: The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis... Agent: Locke Lord Bissell & Liddell LLP Attn:IPDocketing

20090203888 - Isolated photoprotein aqdecay, and its use: The invention relates to the photoprotein AQdecay, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein AQdecay.... Agent: Barbara A. Shimei Director, Patents & Licensing

20090198042 - Polyvalent vaccine: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens... Agent: Nixon & Vanderhye, PC

20090198043 - Feline il-18 proteins: The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules... Agent: Sheridan Ross PC

20090198044 - Anti-psgl-1 antibodies: Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.... Agent: Wolf Greenfield & Sacks, P.C.