Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 06/09

20090163695 - Process for the preparation of bicyclic peptide compounds: The present invention relates to a new process carried out entirely in solution, for the preparation in high yields of high purity bicyclic peptide compounds of formula (I), useful as intermediates for preparing compounds with pharmacological activity.... Agent: Lorusso & Associates

20090163696 - Method for preparing lysobactin derivatives: e

20090163697 - Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides: Disclosed is a method of coupling an amino or hydroxyl compound with the amino portion of a sulfonamide via condensation with a cyclic thioanhydride. The reaction of cyclic thioanhydrides with amines affords amides functionalized with thioacids, which can be trapped in situ with preferably electron deficient arylsulfonamides. In this manner... Agent: Olson & Cepuritis, Ltd.

20090163698 - Method for preparing antibody conjugates: The subject matter described herein relates to a process for preparing an antibody, in one embodiment a Fab′, in very good yields and purity, under conditions where the presence of heavy and light chain antibody fragments is minimized. More particularly, the subject matter described herein relates to a process for... Agent: Philip S. Johnson Johnson & Johnson

20090163699 - Fc variants with altered binding to fcrn: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.... Agent: Xencor

20090156784 - Polyester for toner: A polyester for a toner, obtainable by polycondensing an alcohol component and a carboxylic acid component containing a fumaric acid-modified rosin; and a toner containing the polyester for a toner. The polyester for a toner of the present invention is usable as a resin binder for a toner usable in,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090156785 - Method of producing fr901228: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090156786 - Mammalian genes: related reagents and methods: Purified genes encoding proteins from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Dnax Research Inc. Legal Department

20090156787 - Antibody production elicited by a dna vaccine delivered by electroporation: There are provided methods of generating antibodies in a mammal against recombinant antigens using DNA plasmids capable of expressing said antigens in cells of said mammal, comprising: injecting into tissue of said mammal a DNA plasmid comprising an encoding sequence operably linked to a promoter, electroporating said tissue with an... Agent: Pepper Hamilton LLP

20090156788 - Engineered anti-il-23 antibodies: Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.... Agent: Dnax Research Inc. Legal Department

20090156790 - Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and... Agent: Knobbe Martens Olson & Bear LLP

20090156789 - Compositions, methods and kits useful for the diagnosis and treatment of spinal muscular atrophy: The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090156791 - Molecule transfer/delivery system: A molecule transfer and delivery system includes a loading zone (50) for loading a targeted cargo molecule (30) on a carrier molecule (20) making use of a hybridization nature of nucleotides, and an unloading zone (40) for unloading the targeted cargo molecule from the carrier molecule making use of the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090149628 - Insulinotropic peptide synthesis using solid and solution phase combination techniques: The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of... Agent: Roche Palo Alto LLC Patent Law Department

20090149629 - Crfr1 selective ligands: e

20090149630 - Stabilized alpha helical peptides and uses thereof: Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive... Agent: Fish & Richardson PC

20090149632 - Antibacterial peptide: The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID... Agent: Factor & Lake, Ltd

20090149631 - Methods and compositions for protein labeling using lipoic acid ligases: The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants.... Agent: Wolf Greenfield & Sacks, P.C.

20090149633 - Artificial diet for lepidopteran insects and production method thereof, lepidopteran insect and production method thereof, and biological material: An artificial diet for lepidopteran insects of the present invention, including: a protein; and a carbohydrate, wherein a content of a stable isotope is equal to or greater than 50 atom %. A method for producing an artificial diet for lepidopteran insects, including: a defatting treatment step of subjecting a... Agent: Nixon & Vanderhye, PC

20090149634 - Porous body comprising apatite/collagen composite fibers and its production method: A porous body comprising apatite/collagen composite fibers, which has a half-value period of strength of 0.8-1.6 hours, the half-value period of strength being the time until the strength of the porous body of 10 mm×10 mm×4 mm comprising apatite/collagen composite fibers is reduced to half, after the porous body degassed... Agent: Greenblum & Bernstein, P.L.C

20090149635 - Antibodies to human zcytor17 ligand: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent: Zymogenetics, Inc. Intellectual Property Department

20090149636 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department

20090149637 - Human antibodies derived from immunized xenomice: Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090149638 - Systems and methods for purifying proteins: Described herein are novel systems and downstream protein purification (DSP) processes that provide high quality product rapidly, and on a large scale. Many of the processes enable one chromatography step to follow another chromatography step without an intermediate ultrafiltration/diafiltration (UFDF) step. These optimized processes allow for automation on the manufacture... Agent: Lowrie, Lando & Anastasi, LLP

20090143565 - Methods for the synthesis of two or more dicarba bridges in organic compounds: Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges.... Agent: Fish & Richardson PC

20090143566 - Growth factor analogs: The invention provides synthetic heparin-binding growth factor analogs of formulas I or II as given in the specification, having two peptide chains branched from a dipeptide branch moiety composed of at least one and preferably two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor... Agent: Peacock Myers, P.C.

20090143567 - Multiblock copolymers having improved mechanical properties: Replacement of the amorphous peptide domain of a structural biopolymer, such as silk from silkworms or spiders, with a nonpeptide segment while maintaining the β-sheet forming crystalline segments provides synthetic multiblock copolymers having solid-state structures and mechanical properties similar to the naturally occurring structural biopolymer is described herein. Such synthetic... Agent: Burns & Levinson, LLP

20090143568 - Recombinant gelatins: The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same.... Agent: Fibrogen, Inc.

20090143569 - Bacteriolytic agent: e

20090143570 - Method for isolation of genomic dna, rna and proteins from a single sample: The invention provides systems, methods and kits for the separation and/or purification of at least two cellular components selected from genomic DNA, RNA and proteins. The method includes first lysing a biological sample to generate an aqueous solution containing the cellular components; then applying the aqueous solution to a first... Agent: Ge Healthcare Bio-sciences Corp. Patent Department