Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 03/09

20090082547 - Compositions for enhancing transport of molecules into cells: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a... Agent: King & Spalding LLP

20090082548 - System and method for production of antibodies in plant cell culture: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090082549 - Fce-pe chimeric protein for targeted treatment of allergy responses a method for its production and pharmaceutical compositions containing the same: The present invention generally relates to a new approach for the therapy of allergic responses, based on targeted elimination of cells expressing the FcεRI receptor by a chimeric cytotoxin FC2′-3-PE40. A sequence encoding amino acids 301-437 of the Fc region of the mouse IgE molecule was genetically fused to PE40—a... Agent: Volpe And Koenig, P.C.

20090082550 - Antibody compositions and methods: Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without aggregation or precipitation, providing, for example, for increased storage stability and the ability to administer higher therapeutic doses.... Agent: Edwards Angell Palmer & Dodge LLP

20090082551 - Method, compositions and classification for tumor diagnostics and treatment: The present invention is directed towards classifying tumor biomarkers, particularly membrane receptors, and more particularly the gastrin-releasing peptide (GPR) receptors, identified in patient samples, then linking therapeutic agents (chemical, radiological, or biological) to patient-specific ligands that bind to such receptors, clinicians can produce diagnostic and treatment compositions and implement treatment... Agent: Mchale & Slavin, P.A.

20090082552 - Microfluidic protein assay: A microfluidic device for separating a fluid sample into components is disclosed. The microfluidic device is used for assaying proteins for the purpose of identification of protein species. The microfluidic device employs integrated features such as a sample well for holding a protein sample, a thermal control device for heating... Agent: Agilent Technologies Inc.

20090076244 - Beta helical peptide structures stable in aqueous and non-aqueous media and methods for preparing same: Disclosed is a method of making peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating D,L- or L,D-amino acids having an N and C termini is joined by at least one turn region to a second linear peptide chain comprising alternating... Agent: Naval Research Laboratory Associate Counsel (patents)

20090076245 - Hiv-1 subtype isolate regulatory/accessory genes, and modification and derivatives thereof: The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates to a vaccine including two or more of the nucleotide sequences, and nucleotide sequences... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20090076246 - Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure: The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and... Agent: Trask Britt

20090076247 - High pressure refolding of monoclonal antibody aggregates: Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.... Agent: Morrison & Foerster LLP

20090076249 - Antibodies against cd38 for treatment of multiple myeloma: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090076248 - Plus end-directed microtubule motor required for chromosome congression: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.... Agent: Medlen & Carroll, LLP

20090076250 - Substance that specifically recognizes pd-1: Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality.... Agent: Sughrue-265550

20090076251 - Fcgammariib specific antibodies and methods of use thereof: The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, more particularly the extracellular domain of FcγRIIB with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA, and block the Fc binding site of FcγRIIB. The present invention also encompasses... Agent: Edell, Shapiro & Finnan, LLC

20090076252 - Continuous process for production of oil seed protein isolate: Oil seed protein isolates, particularly canola protein isolate, are produced continuously from oil seed meals, preferably at a high purity level of at least about 100 wt % (N×6.25), by a process wherein oil seed protein is continuously extracted from oil seed meal, the resulting protein solution is continuously concentrated,... Agent: Sim & Mcburney

20090069534 - Hydrochloride salts of a glycopeptide phosphonate derivative: Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.... Agent: Theravance, Inc.

20090069535 - Ligand (act-4-l) to a receptor on the surface of activated cd4+ t-cells: The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4+ T-cells. An exemplary ligand is designated ACT-4-L-h-1. Preferred fragments include purified extracellular domains of ligands. The invention also provides humanized and human antibodies to the ligand. The invention further provides methods of using the... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090069536 - Amide forming chemical ligation: An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the α-carbon of the ketoacid and the nitrogen... Agent: Richard Aron Osman

20090069537 - Treatment of disease by inducing cell apoptosis: The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090069538 - Method of producing peptide: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1%... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090069539 - Androgen regulated prostate specific nucleic acids: The present invention provides novel androgen regulated nucleic acid molecules. Related polypeptides and diagnostic methods also are provided.... Agent: Mcdermott, Will & Emery

20090069540 - Stretchable collagen material and manufacturing method and use thereof: The present invention provides a stretchable collagen material, particularly collagen derived from fishes, having excellent stretching property and mechanical strength, which can be widely used as a cell carrier and medical material, and to a method for manufacturing the same. By thermally treating a gel comprising collagen fiber cross-linked by... Agent: Novak, Druce & Quigg LLP

20090069541 - Production of biopolymer film, fibre, foam and adhesive materials from soluble s-sulfonated keratin derivatives: Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with... Agent: Holland & Hart, LLP

20090069542 - Process of extracting high quality proteins from cereal grains and their byproducts using acidic medium and a reducing agent: The present invention is directed to a method for processing a plant-based protein source, the method comprising an acidic extracting solution comprising a reducing agent is useful for extracting and isolating proteins from plant-based protein sources.... Agent: Thompson Coburn, LLP

20090069543 - Factor ixa for the treatment of bleeding disorders: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method... Agent: Baxter Healthcare Corporation

20090069544 - Humanized antibodies that recognize beta amyloid peptide: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.... Agent: Townsend And Townsend And Crew, LLP

20090069545 - Defensin- specific antibodies: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic... Agent: Greenlee Winner And Sullivan P C

20090069546 - Pyrazole-based cyanine dye: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090069548 - Immobilized proteins and methods and uses thereof: The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also relates to biological molecules used in such techniques, including proteins, and detection methods... Agent: The Mccallum Law Firm, P. C.

20090069547 - Stabilization of mammalian membrane proteins by short surfactant peptides: The present invention provides for a method and kits for stabilizing mammalian membrane protein using short surfactant peptides. The mammalian membrane protein can be a G protein-coupled receptor.... Agent: Elmore Patent Law Group, PC

20090069549 - Protein extraction buffer, a kit comprising it and method of its use: Disclosed are detergent-free protein extract buffers to extract proteins from formalin-fixed paraffin-embedded tissue sections, kit comprising the buffer, and methods for using the buffer to extract proteins from formalin-fixed, paraffin-embedded tissue sections.... Agent: Wilmerhale/boston

20090069550 - Lignin and other products isolated from plant material, methods for isolation and use, and compositions containing lignin and other plant-derived products: Lignin polymers having distinctive properties, including a generally high molecular weight and generally homogeneous size distribution, as well as preservation of native reactive side groups, are isolated by solvent extraction of plant materials. Methods for isolation of lignin polymers, and for use of the isolated lignin polymers are disclosed. Compositions... Agent: Speckman Law Group PLLC

20090062509 - Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines: A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for... Agent: Kramer Levin Naftalis & Frankel LLP

20090062510 - Human chemotactic cytokine i polypeptides: Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090062511 - Process for the preparation of bivalirudin and its pharmaceutical compositions: m

20090062512 - Comparative ligand mapping from mhc class i positive cells: The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules... Agent: Dunlap Codding, P.C.

20090062513 - Production of bypolymer film, fibre, foam and adhesive materials from soluble s-sulfonated keratin derivative: Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with... Agent: Office Of Naval Research

20090062514 - Plant viral particles comprising a plurality of fusion proteins consisting of a plant viral coat protein, a peptide linker and a recombinant protein and use of such plant viral particles for protein purification: A process of purifying a protein of interest using viral particles or virus-like particles comprising a plurality of fusion protein molecules, said fusion protein comprising the following fusion protein domains: (i) a plant viral coat protein, (ii) a recombinant protein, and (iii) optionally a peptide linker linking said plant viral... Agent: Alston & Bird LLP

20090062515 - Method for purifying bioactive substances: A method for purifying bioactive substances includes the steps of: causing a bioactive substance having histidine units to contact media, each constituted by a substrate, ligands which are physically attached to the surface of the substrate, and Cu(II) or Fe(II) metal ions which are covalently bonded to the ligands; causing... Agent: Sughrue Mion, PLLC

20090062516 - Lignin and other products isolated from plant material, methods for isolation and use, and compositions containing lignin and other plant-derived products: Lignin polymers having distinctive properties, including a generally high molecular weight and generally homogeneous size distribution, as well as preservation of native reactive side groups, are isolated by solvent extraction of plant materials. Methods for isolation of lignin polymers, and for use of the isolated lignin polymers are disclosed. Compositions... Agent: Speckman Law Group PLLC