Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 02/09

20090054622 - Peptide variants of the tumor marker muc1 and their application: The invention refers to peptide variants of the tumor marker MUC1 and their application in antigenic and immunogenic remedies. It concretely refers to peptide variants of the MUC1 tandem repeat unit within the VNTR (=variable number of tandem repeats) domain.... Agent: Buchanan Ingersoll & Rooney PC

20090054623 - Lipo-conjugation of peptides: The present invention provides peptide conjugates that are formed between a modified lipid and a glycosyl residue and/or an amino acid residue on a peptide. The modified lipid includes a modifying group and a lipid linking group. Exemplary lipid linking groups include myristoyl, palmitoyl, and isoprenyl moieties.... Agent: Morgan, Lewis & Bockius LLP (sf)

20090054626 - Crustacean-derived protein having antifreeze activity: e

20090054624 - Pro1190 polypeptides: The present invention is directed to novel polypeptides having homology to CDO protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies... Agent: Genentech, Inc.

20090054625 - Recombinant protein variants: The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.... Agent: Darby & Darby P.C.

20090054628 - Method and system for in vitro protein folding: A method of recovering a refolded protein involves static mixing a concentrated solution of a denatured protein with a refolding diluent to obtain the refolded protein. The method is particularly suitable for microbially produced recombinant proteins in large processing volumes. The denatured protein solution can be obtained by isolating protein... Agent: Novartis Corporate Intellectual Property

20090054627 - Process for the purification of il-18 binding protein: The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid using aqueous two-phase partitioning.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090054629 - Inhibitors of transthyretin amyloid fibril formation: Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.... Agent: The Scripps Research Institute

20090054630 - Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors: Antibodies that bind CCX-CKR2 are described.... Agent: Townsend And Townsend And Crew, LLP

20090054631 - Compositions and methods for treatment of non-hodgkin's lymphoma: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.... Agent: Genentech, Inc.

20090054632 - Hydrophobically-modified protein compositions and methods: Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic... Agent: Ropes & Gray LLP

20090054633 - Method for controlling stability of nanofabricated polypeptide multilayer films, coatings, and microcapsules: Disclosed herein is a method of controlling the stability of multilayer polypeptide films. A method of controlling the stability of a film, comprises exposing the film to an oxidizing agent or a reducing agent, wherein the film comprises a plurality of layers, the layers comprising alternating oppositely charged polypeptides, wherein... Agent: Cantor Colburn, LLP

20090048427 - Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders: Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to... Agent: Townsend And Townsend And Crew, LLP

20090048428 - Peptide tags for the expression and purification of bioactive peptides: Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090048429 - Processes and intermediates: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.... Agent: Miller Canfield Paddock And Stone PLC

20090048430 - Site specific protein modification: The present invention relates, in general, to protein modifications and, in particular, to a method of effecting site-specific labeling of proteins with covalently coupled reporter groups. The invention further relates to a method of effecting orientation-specific immobilization of proteins on a solid surface. The invention also relates to products produced... Agent: Nixon & Vanderhye, PC

20090048431 - Multivalent clostridial toxins: The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful... Agent: Allergan, Inc.

20090048432 - Anti-il-20 antibody and its use in treating il-20 associated inflammatory diseases: This invention features an antibody specifically binding to human IL-20 (e.g., mAb 7E and a equivalent thereof) and its use in treating an IL-20 associated inflammatory disease, such as atherosclerosis, RA, psoriasis, psoriatic arthritis, bacteria-induced gastric ulcer, and acute renal failure.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090048433 - Scalable process for protein purification: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090043073 - Alpha-fetoprotein peptides and uses for imaging: The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090043074 - Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation: The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of loss of body weight and body fat, prophylaxis or treatment of cachexia, stimulation of appetite, stimulation of food... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20090043075 - Recombinant peptide production using a cross-linkable solubility tag: The invention relates to the recombinant expression of a peptide of interest in the form of a fusion protein comprising a solubility tag. The fusion protein comprises at least two portions separated by a cleavable peptide sequence wherein one portion is devoid of cysteine residues and the second portion comprises... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090043076 - Modified interferon beta with reduced immunogenicity: The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue... Agent: Olson & Cepuritis, Ltd.

20090043077 - Conjugation of streptococcal capsular saccharides: Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidised sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method,... Agent: Novartis Vaccines And Diagnostics Inc.

20090043078 - Gdf-5 protein storage: Improved compositions and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an aqueous solution of GDF-5 and a biocompatible acid, such as hydrochloric, acetic, phosphoric, or trifluoroacetic acid, wherein the solution has a pH of from about 3.0 to about 3.6, thereby providing for... Agent: Philip S. Johnson Johnson & Johnson

20090043079 - Cell culture surfaces having hydrogel supported proteins: A method is disclosed herein for treating a polymeric surface to define an improved cell culture surface. The method includes the steps of: coating the polymeric surface with a hydrogel; and attaching proteins to the hydrogel-coated surface. Advantageously, a method is provided which consistently produces improved cell culture surfaces that... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090043080 - Purification of a bulk of a factor vii polypeptide by fractionated elution from an anion-exchange material: The present invention relates to the purification of a Factor VII polypeptide from a bulk of a Factor VII polypeptide with respect to desirable glycoforms by fractionated elution from an anion-exchange material with an eluting buffer comprising a certain concentration of calcium ions. The present invention renders it possible to... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090036647 - Bitoran which is trypsin-inhibitor-like protein derived from bitis arietans venom, and use thereof as blood coagulation factor xa inhibitor: P

20090036648 - Egvi endoglucanase and nucleic acids encoding the same: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same.... Agent: Danisco US Inc., Genencor Division

20090036649 - Methods for arbitrary peptide synthesis: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20090036650 - Compounds and methods for peptide synthesis: A backbone nitrogen modifying group can prevent aggregation of peptides during peptide synthesis. The modifying group can promote aqueous solubility of the peptides, and be compatible with solid phase peptide synthesis. Methods for making peptides are also described.... Agent: Steptoe & Johnson LLP

20090036651 - Purification of proteins: The present invention relates to a selectively soluble polymer capable of binding to one or more constituents in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain... Agent: Nields & Lemack

20090036652 - Purification of proteins using preparative reverse phase chromatography (rpc): The present invention provides a method for industrial-scale protein separation by reverse phase chromatography by use of a buffer system and an additional salt.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090036653 - Methods for the directed expansion of epitopes for use as antibody ligands: The instant invention comprises a process for selecting and manufacturing antibodies useful for therapeutic, prophylactic, diagnostic or research purposes using epitope peptide mixtures synthesized by the solid phase synthesis, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute... Agent: Ropes & Gray LLP

20090036654 - Crystal structure of rho-kinase i kinase domain complexes and binding pockets thereof: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure... Agent: Ropes & Gray LLP

20090036655 - Production of 2s canola protein involving ion exchange: Substantially pure 2S canola protein is obtained substantially free from 7S and 12S canola protein by a procedure in which 2S canola protein is captured by binding to a cation-exchange medium while permitting other proteins and impurities to be washed away. The 2S canola protein then is removed from the... Agent: Sim & Mcburney