Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 12/08

20080319162 - Process and intermediates for the synthesis of caspofungin: The present invention relates to novel processes for preparing certain aza cyclohexapeptide compounds, e.g. caspofungin, novel intermediates used in said processes and a process for preparing said intermediates. In particular, the intermediates have formula (II), wherein X is amino or substituted amino and contains a cyano/nitrile functionality.... Agent: Manelli Denison & Selter

20080319163 - Method for isolating and purifying immuno-modulating polypeptide from cow placenta: The present invention provides a method for isolating and purifying immuno-modulating polypeptide from cow placenta, which is characterized by using the steps of anion-exchange chromatography, gel exclusion chromatography and reverse-phase high performance liquid chromatography to isolate and purify immuno-modulating polypeptide from cow placenta, identifying its activity of stimulating lymphocyte proliferation... Agent: Michael L. Crapenhoft C/o Hiroe And Associates

20080319164 - Synthesis and application of a family of new materials resulting from the chemical cross-linking between gelatine and organic salts: The invention relates also to the application of said synthesized new materials in the domains of physics, chemistry and biology, disclosing the process for the synthesis of the new materials and the use thereof as supports for biocatalysts immobilization in chemical reactions, controlled drug delivery, manufacturing of sensors/biosensors aimed at... Agent: Pearl Cohen Zedek Latzer, LLP

20080319165 - Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least one neuropeptide: e

20080319166 - Treatment of implantable medical devices resistant to calcification:

20080319169 - Biomimetic materials for protein storage and transport: The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant;... Agent: Cherskov & Flaynik

20080319167 - Clostridial toxin derivatives able to modify peripheral sensory afferent functions: This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent... Agent: Morris Manning Martin LLP

20080319168 - Method for coating surfaces with hydrophobins: A method for coating surfaces with hydrophobin fusions at a pH of ≧4, and a surface having a coating which comprises at least one hydrophobin fusion.... Agent: Connolly Bove Lodge & Hutz, LLP

20080319170 - Methods and uses of antibodies in the purification of interferon: The present invention provides improved methods and uses of an immunoglobulin in the purification of an interferon composition. The methods of the invention provide for the use of a monoclonal antibody in the purification of an interferon composition comprising a plurality of interferon alpha subtypes. The use of the monoclonal... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080319171 - Continuous process for production of oil seed protein isolate: Oil seed protein isolates, particularly canola protein isolate, are produced continuously from oil seed meals, preferably at a high purity level of at least about 100 wt % (Nx 6.25), by a process wherein oil seed protein is continuously extracted from oil seed meal, the resulting protein solution is continuously... Agent: Sim & Mcburney

20080319172 - Device for detecting molecules, method for detecting molecules: A construct is provided that is capable of binding a plurality of molecules, the construct comprising a first moiety with a first molecule binding region and a first molecule non-binding region; and a second moiety with a second molecule-binding region and a second molecule-non-binding region, whereby the first binding region... Agent: Cherskov & Flaynik

20080319173 - Blood group antigen fusion polypeptides and methods of use thereof: The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection.... Agent: Ivor Elrifi, Esq. Mintz, Levin, Cohn, Ferris,

20080319174 - Chimera humanized vascular endothelial growth factor: An object of the present invention is to provide a chimera VEGF-E having a reduced antigenicity while maintaining the activity of VEGF-E. The present invention provides a chimera protein having an activity of growing vascular endothelial cells, which is obtained by substituting a part of the sequence of a VEGF... Agent: Greenblum & Bernstein, P.L.C

20080319175 - Transthyretin stabilization: Dibenzofuran-4,6-dicarboxylic acid core structures having an aromatic substituent appended onto the at the C1 position using three different types of linkages are disclosed herein and shown to afford exceptional amyloidogenesis inhibitors that display increased affinity and greatly increased binding selectivity to TTR over all the other plasma proteins, relative to... Agent: The Scripps Research Institute

20080312407 - Glycopeptide phosphonate derivatives: Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.... Agent: Theravance, Inc.

20080312408 - Method of separating a peptidoglycan recognition protein from a hemolymph tenebrio molitor larvae: Provided is a method of separating a peptidoglycan-recognition protein from the hemolymph of Tenebrio molitor larvae, the method including: (a) preparing an affinity chromatography column by packing a column with a resin bound with at least one synthetic peptidoglycan; (b) applying the hemolymph of Tenebrio molitor larvae to the affinity... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080312410 - Cysteine-containing peptide tag for site-specific conjugation of proteins: The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the... Agent: Wiggin And Dana LLP Attention: Patent Docketing

20080312409 - Genetically engineered cdna of rat bcl-x gene and an improved protein: The present invention provides an genetically engineered cDNA of the rat bcl-x gene, which has at least one substitution selected from the substitutions that change residues 22 Tyr to Phe, residues 26 Gln to Asn and residues 165 Arg to Lys, in the coding region of rat bcl-x cDNA of... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080312411 - Use of activated polymers for separation of protein and polypeptide multimers: The invention relates to a use of an activated polymer to separate a non-covalently associated polypeptide multimer comprising multiple polypeptide subunits into multiple polypeptide subunits.... Agent: Clark & Elbing LLP

20080312412 - Chimeric immunogens: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory... Agent: Sim & Mcburney

20080312413 - Compositions and methods for treating conditions related to ephrin signaling with cupredoxins: The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives... Agent: Don J. Pelto Sheppard, Mullin, Richter & Hampton LLP

20080312414 - Apparatus for measuring high density lipoproteins and method of separating high density lipoproteins: The present invention provides a method of separating lipoproteins other than high density lipoproteins from a biological fluid. The method can quickly measure HDL cholesterol with a simple configuration and without the need of providing additional complicated devices. In this method, high density lipoproteins not generating any precipitate are fractionated... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20080312415 - Long lasting fusion peptide inhibitors for hiv infection: This invention relates to enfuvirtide peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to enfuvirtide derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with... Agent: Lowrie, Lando & Anastasi, LLP

20080312416 - Composite materials comprising supported porous gels: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080312417 - Ucp5: The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous... Agent: Gates & Cooper LLP Howard Hughes Center

20080312418 - Antibody specific for human 4-1bb receptor: The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from cDNA 4-1BB. A fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB... Agent: Barnes & Thornburg LLP

20080312419 - Genes conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to glyphosate herbicides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression... Agent: Alston & Bird LLP

20080312420 - Monoclonal antibodies for detection of urinary trypsin inhibitors: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.... Agent: Siemens Corporation Intellectual Property Department

20080312421 - Use of a33 antigens and jam-it: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.... Agent: Heller Ehrman LLP

20080312422 - Processes for making hydrazides: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production... Agent: Wyeth Patent Law Group

20080312423 - Preparation of metal ion-lactoferrin: The present invention provides processes for preparing metal ion-lactoferrin by first immobilising lactoferrin in a lactoferrin-binding matrix and then contacting the immobilised lactoferrin with a source of metal ions, preferably a milk composition containing metal ions. A preferred product of the process is iron-lactoferrin.... Agent: Knobbe Martens Olson & Bear LLP

20080312424 - Method and compositions for the detection of protein glycosylation: The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits... Agent: Invitrogen C/o Intellevates Sughrue Mion PLLC

20080312425 - Ion exchange chromatography and purification of antibodies: A novel method for purifying antibody and other product protein concomitant with removing aggregates made up from single product protein species is devised.... Agent: Warren M. Check, Jr. Wenderoth, Lind & Ponack, L.L.P.

20080306242 - Intermediates for lhrh antagonist synthesis, process for the production, and process for lhrh antagonist production: The peptides Ac-D-2Nal-D-4ClPhe-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P1-Ser(P2)-MMeTry(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 and P1-Ser(P2)-NMeTry(P3)-D-Asn-Leu-Lys(iPr,P4)-Pro-D-AlaNH2.... Agent: Dickstein Shapiro LLP

20080306243 - Hla-binding peptide, and dna fragment and recombinant vector coding for said hla-binding peptide: An HLA-binding peptide binding to an HLA-A type molecule is provided that includes at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 30, and not less than 8 and not more than 11 amino acid residues. All of these amino... Agent: Sughrue Mion, PLLC

20080306244 - Renta: an hiv immunogen and uses thereof: The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, including Reverse Trancriptase (RT), Env (gp41), Nef and Tat proteins, as... Agent: Frommer Lawrence & Haug

20080306245 - Method for the production of albumen conjugates with non-steroidal antirheumatic drugs (nsar): The present invention concerns NSAR (non-steroidal antirheumatic agents)-protein conjugates and in particular NSAR-albumin conjugates, processes for their production and their use as pharmaceutical preparations especially for treating inflammations.... Agent: Morris Manning Martin LLP

20080306246 - Process for attaching effector molecules to proteins: The present invention provides a process for attaching one or more effector molecules to one or more cysteines in a protein comprising: a) activating one or more cysteines in the protein by diafiltering the protein against a monothiol reducing agent or a multi-thiol reducing agent which is incapable of forming... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080306247 - Antibody-containing solution formulations: An antibody-containing solution formulation comprising an organic acid and a surfactant as stabilizers; a method for suppressing the formation of visible insoluble matter and/or insoluble particles due to the presence of metal ions in an antibody-containing solution formulation, which comprises adding an organic acid to the solution; a method for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080306248 - Conjugate of biomacromolecule with bioreductive and preparative method thereof: Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided. The biomacromolecule is selected from apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, EGF, folacin acid or transcobalamin, and the bioreductive agent is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal... Agent: Schmeiser, Olsen & Watts

20080306249 - Method of selectively removing protein from biological samples using chemicals: where at least two of R1, R2, and R3 substituents are substituted or unsubstituted C1-C6 alkyl groups and the other substituent is a hydrogen atom or a substituted or unsubstituted C1-C6 alkyl group, a is an integer of 1 to 6 and b is 0 or 1, wherein b is... Agent: Cantor Colburn, LLP

20080300382 - Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions: The invention relates to a method of improving the immunogenicity of an immunogen, antigen or hapten, by means of coupling with a small support peptide. More specifically, the invention relates to a method of preparing an immunogenic complex, as well as the complexes that can be obtained using one such... Agent: Birch Stewart Kolasch & Birch

20080300383 - Methods for the production of polymer carrier materials based on carbon hydrate-bis(meth)acryl-amides: The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080300384 - T-bet compositions and methods of use thereof: Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080300385 - Covalently-linked complexes of hiv tat and env proteins: Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is... Agent: Novartis Vaccines And Diagnostics Inc.

20080300386 - Extraction and partitioning of molecules: Methods of extracting a component of interest from a plurality of components are described.... Agent: Lowrie, Lando & Anastasi, LLP