Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 11/08

20080293915 - Nanoscale neuromodulating platform for retina neuron activation apparatus and method: Postsynaptic membrance receptor proteins of retinal neurons proximal to the rods and cones mediate the transmission of visual signals at multiple types of chemical synapses in the normally functioning retina, and there is reason to believe that these proximal retinal neurons in certain cases remain functional despite the disease-induced loss... Agent: Husch Blackwell Sanders LLP

20080293916 - Hla-binding peptide, and dna fragment and recombinant vector coding for said hla-binding peptide: An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 60, and not less than 8 and not more than 11 amino acid residues is provided. Any of... Agent: Sughrue Mion, PLLC

20080293917 - Peptide purification by means of metal ion affinity chromatography: A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080293918 - Method and apparatus for extraction of protein material from arthropod glands and a membrane formed therefrom: An apparatus and method for the extraction of material from glands of arthropods. The apparatus comprises a container in which at least part of the glands are placed and a buffer solution at least partially immersing the glands. Gland material is collected in the material collection area of container. In... Agent: Intellectual Property / Technology Law

20080293919 - Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials: The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one... Agent: David S. Resnick

20080293920 - Arginine analogs, and methods for their synthesis and use: The present invention relates to novel arginine analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or free thiol (—SH) group, thereby providing a convenient linkage chemistry for coupling to a suitable group on a target such as a protein, polypeptide, detectable label... Agent: Foley & Lardner LLP

20080293921 - Production and use of novel peptide-based agents for use with bi-specific antibodies: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. In preferred... Agent: Immunomedics, Inc.

20080293922 - Beta-amyloid binding factors and inhibitors thereof: The present invention relates to a VEGF polypeptide that binds to Aβ. The present invention also relates to a compound that sequesters Aβ. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits... Agent: Jhk Law

20080293923 - Crystal structure of the complex of hepatocyte growth factor beta chain with met receptor and methods of use: The disclosure provides a crystal structure of a complex of the HGF β-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met... Agent: Morrison & Foerster LLP

20080293924 - Process for the isolation and/or purification of proteins: The invention relates to the process for the isolation and/or purification of biologically active proteins, preferably TNF-alpha or TNF-alpha analogues. The process of the present invention results in the production of high yields of proteins, preferably TNF-alpha or TNF alpha analogues with a purity of greater than 98%. The described... Agent: Sandoz Inc

20080293925 - Affinity adsorbents for plasminogen: For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080293926 - Preparation of biomolecules: The present invention relates to a method of separating a target from a liquid, which includes providing a polymer in an aqueous liquid, which polymer comprises at least one hydrophobic portion; contacting the polymer-containing liquid with the liquid comprising the target; applying a stimulus to the resulting mixture; and maintaining... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080293927 - Method for preparing pelleted lignocellulosic ion exchange materials: The invention discloses a method for preparing pelleted lignocellulosic ion exchange materials for use in a variety of industrial and municipal water treatment applications. The method involves milling, sifting, binding, extruding, cutting, and baking steps. The resultant pellet is suitable for use in ion exchange columns and can be regenerated.... Agent: Bradley S. Strahm

20080287648 - Method for solid phase peptide synthesis: A novel method for synthesizing a Hirulog peptide is devised.... Agent: Nixon & Vanderhye, PC

20080287650 - High purity peptides: The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing... Agent: Kenyon & Kenyon LLP

20080287649 - Methods for the synthesis of cyclic peptides: Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and... Agent: Roche Palo Alto LLC Patent Law Department

20080287651 - Silk thread containing spider thread protein and silk worm producing the silk thread: A transgenic silkworm having transferred therein a gene which encodes spider thread protein having desired properties of high strength and high elasticity while leaving the silkworm fibroin H chain gene intact, by means of utilizing a transposon function, is used to produce in the transgenic silkworm a spider thread protein... Agent: Birch Stewart Kolasch & Birch

20080287652 - Antagonists against interaction of pf4 and rantes: The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment.... Agent: Rankin, Hill & Clark LLP

20080287653 - Method for producing inhibitors and inhibitors formed therefrom: The present invention relates to methods for producing inhibitors for protein deacetylases, and to the compounds and/or products produced by such methods. More specifically, the present invention relates to methods for producing inhibitors for human class III protein deacetylases or sirtuins, and to the compounds and/or products produced by such... Agent: Roetzel And Andress

20080287654 - Peptide mediated synthesis of metallic and magnetic materials: The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.... Agent: Foley And Lardner LLP Suite 500

20080287655 - Method of producing s-nitrosoprotein preparation: A protein is efficiently nitrosylated with nitrogen monoxide by merely mixing S-nitrosoglutathione as a nitrogen monoxide donor with a protein solution containing a stabilizing agent comprising at least one compound or a combination of plural compounds selected from an N-acetylamino acid, a fatty acid, and a fatty acid salt. The... Agent: Kubovcik & Kubovcik

20080287656 - Device and method for cell free analytical and preparative protein synthesis: At the pores 10, two zones, the cis zone 50 and the trans zone 60, are separated from one another on a support body 90 by means of translocation systems 20 in such a way that only those proteins that are recognized by the translocation systems 20 due to specific... Agent: Intellectual Property / Technology Law

20080287657 - Alteration of fc-fusion protein serum half-lives by mutagenesis: The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified... Agent: Townsend And Townsend And Crew LLP

20080287658 - Docetaxel immunoassay: Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids.... Agent: Gibbons P.C.

20080287659 - G-csf conjugates: v

20080287660 - Novel orff and orff' polypeptides, nucleic acid molecules encoding the polypeptides and applications thereof: The invention relates to novel pathogenic OrfF and OrfF′ polypeptides derived from Xanthomonas campestris pv. campstris, the nucleic acid molecules encoding the polypeptides and the uses of the same for detecting or preventing a black-rot disease of a crucifer plant, making organic fertilizer or composting and being a biofilter for... Agent: Ladas & Parry LLP

20080287661 - Devices and methods for reducing matrix effects: Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means... Agent: Varian Inc. Legal Department

20080281075 - Asymmetric synthesis of peptides: The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without... Agent: Elmore Patent Law Group, PC

20080281076 - Il-6 binding proteins: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.... Agent: Amgen Inc.

20080281077 - Protein sweetener: Disclosed herein are sweet proteins that are variants of Brazzein, and nucleotide sequences capable of expressing them. Through a replacement of a tyrosine residue at the C terminus in the naturally occurring Brazzein sequence, or the insertion of two residues (at least one being isoleucine, glycine or proline) before the... Agent: Quarles & Brady LLP

20080281078 - Ion exchange chromatography of glp-1, analogs and derivatives thereof: The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said GLP-1 and related impurities, and to an industrial method including such ion exchange chromatography process.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080281079 - Bioactivation of particles: Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more... Agent: Venable LLP

20080281080 - Purification of recombinant human factor xiii: The present invention provides improved methods for the purification of factor XIII. In particular, the methods provide compositions containing 5% or less contaminating proteins. In particular embodiments of the present invention the methods provide purified factor XIII compositions comprising less than 1% activated factor XIII, less than 2% protein aggregates,... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080281081 - Polyvinyl pyrollidone cryoprecipitate extraction of clotting factors: Blood collection, processing and transfer leads to the separation of discrete fractions by adding additional citrate (trisodium citrate) to bring the citrate concentration to 10%-15% w/v thereby leading to enhanced yield and purity of cryoprecipitate. The improved cryoprecipitate then yields concentrated clotting factors by an improved extraction process which uses... Agent: Stefan Kirchanski

20080281082 - Humanized antibodies that recognize beta amyloid peptide: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.... Agent: Townsend And Townsend And Crew, LLP

20080281083 - Antigen of the pm-2 antibody and use thereof: A polypeptide, which is expressed on the cell surface as a membrane-bound protein, is glycolyzed at one or more points (i.e., membrane glycoprotein) and has an amino acid sequence that corresponds partially or completely to that of the integrin binding protein p80 (accession #AJ131720) or REV1 (accession #AF206019.) The membrane... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080281084 - Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor: Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.... Agent: Novartis Vaccines And Diagnostics Inc.

20080281085 - Methods and kits for folding proteins: The invention relates to methods for folding protein comprising providing an aqueous solution of a protein in non-native conformation and a linear or branched sugar polymer comprising three or more saccharide units, or a derivative thereof at a concentration suitable to permit folding of the protein and incubating the solution... Agent: Wolf Greenfield & Sacks, P.C.

20080275213 - Synthesis of carbohydrate-templated amino acids and methods of using same: The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.... Agent: Fulbright & Jaworski L.L.P.

20080275214 - Replikins and mentods of identifying replikin-containing sequences: The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences comprising 7 to about 50 amino acids that contain... Agent: Kenyon & Kenyon LLP

20080275215 - Fluorescein-based compounds and their use for peptide synthesis: The present invention is related to new fluorescein derivatives, the method for producing such derivatives and their use for the synthesis of fluorogenic peptides and in particular protease substrates and peptide ligands.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080275216 - Fluorous capping reagents and methods for peptide purification: Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080275218 - Ly6h gene: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the... Agent: Sughrue Mion, PLLC

20080275217 - Proteins having effects of controlling cell migration and cell death: The present invention relates to which have a role in controlling neuronal cell migration and cell death as well as to the DNA which encode those proteins. It is an object of the present invention to provide control of cell migration and/or cell death by providing a method for screening... Agent: Frommer Lawrence & Haug

20080275219 - In vitro reconstitution of ribonucleoprotein complexes, and methods of use therefor: In general, the invention provides methods and compositions for the in vitro production of ribonucleoprotein complexes and related multimolecular complexes useful for cell-free methods of protein production.... Agent: Edwards Angell Palmer & Dodge LLP

20080275220 - Method for stabilizing a protein: The invention relates to a method for stabilizing an aqueous protein solution against exogenous stress and to the use of a container for stabilizing an aqueous protein solution.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080275221 - Busulfan immunoassay: Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.... Agent: Gibbons P.C.

20080275222 - Method for reducing the allergenic protein content of natural rubber latex articles: The present invention provides a method of reducing and/or neutralizing the allergenic protein content of natural rubber latex articles by exposing the natural rubber latex from which the article is made or the final natural rubber latex to an allergenic protein reducing compound. The allergenic protein reducing compounds for use... Agent: Mcandrews Held & Malloy, Ltd

20080275223 - Method of preparing a liquid, containing proteins for subsequent separation, by using one or more protein-complexing agents: The invention relates to a method of preparing a liquid, which contains proteins (esp. haze sensitive proteins), for subsequent separation of at least haze-forming material, when predetermined filter aids are used. The method comprises the addition of protein-complexing agent to the liquid, which agent is capable of forming a complex... Agent: Paul Grandinetti Levy & Grandinetti