Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 05/08

20080125573 - Antigenic peptides: The present invention relates to peptide antigens of SEQ ID Nos. 1 to 10; repeat motif Gly-X-Gly-Asn-X-Gly of SEQ ID No. 11; and a method of developing drug against tuberculosis, said method comprising steps of targeting the proposed drug towards peptide antigens of SEQ ID Nos. 1 to 11, and... Agent: Thomas Moga Butzel Long

20080125574 - Modified human plasma polypeptide or fc scaffolds and their uses: Modified human plasma polypeptides or Fc and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080125575 - Nanofabricated polypeptide multilayer films, coatings, and microcapsules: Disclosed herein are films, coatings and microcapsules comprising polypeptides. A thin film, for example, comprises a plurality of layers of polypeptides, the layers comprising alternating oppositely charged polypeptides. A first layer comprises a first layer polypeptide comprising one or more amino acid sequence motifs, wherein the first layer polypeptide is... Agent: Cantor Colburn, LLP

20080125576 - Protein isolation: A fusion protein containing a polyhedrin of a virus and a foreign polypeptide sequence. Also disclosed are a recombinant occlusion body containing the fusion protein, an isolated nucleic acid containing a sequence encoding the fusion protein, and a recombinant virus containing the nucleic acid. Within the scope of this invention... Agent: Fish & Richardson PC

20080125577 - Production of canola protein: A canola protein isolate having a protein content of at least about 90 wt % (N×6.25), preferably at least about 100 wt %, and consisting predominantly of the 2S protein and substantially free from the 7S and 12S proteins is prepared. In one aspect, canola oil seed meal is extracted... Agent: Sim & Mcburney

20080125578 - Antibodies to novel lipoxygenase proteins: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080125579 - Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds: The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do not recognize (−) methamphetamine, (−) amphetamine, or (−) MDMA.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080125580 - Refolding of recombinant proteins: Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.... Agent: Genentech, Inc.

20080125581 - Methods and compositions for controlled polypeptide synthesis: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs)... Agent: Berliner & Associates Robert Berliner

20080125582 - Methods and compositions for stabilizing prostate specific antigen: The present invention provides irreversibly linked stable protease-protease inhibitor conjugates, e.g., conjugates comprising α1-antichymotrypsin linked to prostate specific antigen (PSA) or trypsin-antitrypsin conjugates, methods of making such conjugates and methods of using the conjugates, e.g., as controls or calibrators for PSA detection assays or for multi-analyte controls.... Agent: Townsend And Townsend And Crew, LLP

20080119636 - Methods and materials for cancer treatment: Methods and materials for inducing anti-tumor responses in melanoma patients are disclosed. These methods and materials involve gp100-derived polypeptides that contain both a helper T-cell epitope and a cytotoxic T-cell epitope.... Agent: Fish & Richardson P.c.

20080119637 - Pipette tip column, resin and method of use for extracting an analyte: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a polypeptide or protein) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction medium in a column. In some embodiments,... Agent: Phynexus, Inc.

20080119638 - Human endothelin receptor: DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin... Agent: Morrison & Foerster LLP

20080119639 - Novel glyphosate-n-acetyltransferase (gat) genes: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080119640 - Human interferon molecules and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080119641 - Exocrine gland tight junction-constituting protein jeap family: A mouse cDNA library from gene fragments encoding proteins localizing at cell—cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was... Agent: Choate, Hall & Stewart LLP

20080119642 - Controlled surface topography for enhanced protein crystallization rates: A method for accelerating protein crystallization on a substrate is provided, including the steps of providing a coating layer comprising a colloidal solution containing inert particles on at least one discrete testing portion of a testing substrate to provide at least one coated portion, and drying the coated portion so... Agent: Burr & Brown

20080114152 - Peptide compounds: A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database... Agent: Sughrue Mion, Pllc

20080114153 - Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates: The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a... Agent: Sughrue Mion, Pllc

20080114154 - Modified human interferon polypeptides and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080114155 - Modified human interferon polypeptides and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080114156 - Identification of unique binding interactions between certain antibodies and the human b7.1 and b7.2 co-stimulatory antigens: The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies,... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080114157 - Rapid glycopeptide optimization via neoglycosylation: The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomycin aglycon. In particular, the present invention provides a library of vancomycin analogs, where the member of the library... Agent: Quarles & Brady LLP

20080108787 - Purification of insulin-like material by reverse phase chromatography: This invention describes processes for purification of insulin or insulin-like material by reverse phase chromatography by using polystyrenic resins as the chromatographic materials. in particular the present invention describes processes for the purification of a particular insulin-like material from chemically and structurally similar contaminants.... Agent: Bio Intellectual Property Services (bio Ips) Llc

20080108789 - Dna & protein binding miniature proteins: The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.... Agent: Wolf Greenfield & Sacks, P.c.

20080108788 - Recombinant c140 receptor, it's agonists and antagonists, and nucleic acids encoding the receptor: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080108790 - S-alkyl-sulphenyl protection groups in solid-phase synthesis: A novel method for on-resin formation of disulfide-borne cyclization of peptides is devised.... Agent: Nixon & Vanderhye, Pc

20080108792 - Human interferon molecules and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108791 - Modified human interferon polypeptides and their uses: Modified human interferon polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108793 - Novel purified fabi polypeptides from fransicella tularensis: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.... Agent: Goodwin Procter LLP Patent Administrator

20080108794 - Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer: Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The different targets include (i) proinflammatory effectors of the innate immune system, (ii) coagulation factors, and (iii) targets specifically associated with an inflammatory or immune-dysregulatory disorder, with a... Agent: Rossi, Kimms & Mcdowell LLP.

20080108795 - Reagents for the detection of protein phosphorylation in egfr-signaling pathways: The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for... Agent: Simona Levi-minzi, Ph.d. General Counsel

20080108796 - Human il-1 epsilon dna and polypeptides: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and... Agent: Immunex Corporation Law Department

20080108797 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080108798 - Selection of fibronectin scaffolds using nucleic acid-protein fusions: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.... Agent: Ropes & Gray LLP

20080103290 - Process for purifying glycopertide phosphonate derivatives: Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, eluting the resin with an aqueous solution, and isolating... Agent: Theravance, Inc.

20080103291 - Dna molecules encoding ligand gated ion channels from dermacentor variabilis: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel... Agent: Judy Jarecki-black, Ph.d.,j.d Merial Ltd.

20080103292 - Glycopeptide derivatives and pharmaceutical compositions containing the same: e

20080103293 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080103294 - Modified human growth hormone polypeptides and their uses: Modified human growth hormone polypeptides and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.