Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 03/08

20080071062 - Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity: Compounds of formula (SEQ ID NO:2) and (SEQ ID NO:3), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.... Agent: Robert Deberardine Abbott Laboratories

20080071063 - Protein formulations: The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which can be utilized to generate a high protein concentration liquid suitable... Agent: Johnathan Klein-evans

20080071064 - Tempering: The invention relates to the controlled crystallisation of powders, particularly spray-dried powders, for improving the flowability and the aerodynamic characteristics thereof and a method of reducing the electrostatics of a powder.... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080071065 - Fibroblast growth factor-like polypeptides: The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080071066 - Fibroblast growth factor-like polypeptides: The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080071067 - Methods of purifying proteins from egg white: The invention provides methods of purifying proteins, e.g., cytokines, from egg whites.... Agent: Avigenics, Inc.

20080064852 - Low voc bio-source adhesive: A one component adhesive composition is provided, which can be formulated from substantially or totally bio-based, renewable raw materials. Such adhesives can be formulated to have high strength and/or low or substantially no VOC emissions. This can be achieved by utilizing polymers that are derived or extracted from renewable plant... Agent: Stroock & Stroock & Lavan LLP

20080064854 - Composition of a polypeptide and an amphiphilic compound in an ionic complex and the use thereof: An ionic complex precipitate comprising a hedgehog protein and deoxycholate whereby the forming of the complex does not enhance the solubility of said protein, is suitable for increasing the activity of the protein and/or for the delayed release of the protein.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080064853 - Drg11-responsive axonal guidance and outgrowth of neurite (dragon) gene family: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20080064855 - Modified hemoglobin with allosteric effector conjugated: The present invention relates generally to a modified hemoglobin with an allosteric effector conjugated which is capable of dynamically regulating the efficiency of oxygen release. The hemoglobin composition provided in the present invention is utilizing maleimide-Polyethylene glycol-N-hydroxysuccinimidyl as a linker to crossbridge the peptide comprising SEQ ID NO: 1 to... Agent: Birch Stewart Kolasch & Birch

20080064856 - Methods for reducing protein aggregation: Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.... Agent: Wilmerhale/wyeth

20080064857 - Methods and reagents for diagnosis and treatment of diabetes: The invention relates to methods and reagents for diagnosing and treating diabetes.... Agent: Townsend And Townsend And Crew, LLP

20080064858 - Binding partners for the thyrotropin receptor and uses thereof: A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.... Agent: Marina Larson & Associates, LLC

20080064859 - Recombinant mhc molecules useful for manipulation of antigen-specific t-cells: Two-domain MHC polypeptides useful for manipulation of antigen-specific T-cells are disclosed. These polypeptides include MHC class II-based molecules that comprise covalently linked β1 and α1 domains, and MHC class I-based molecules that comprise covalently linked α1 and α2 domains. These polypeptides may also include covalently linked antigenic determinants, toxic moieties,... Agent: Jeffrey J. King, Esq. Black Lowe & Graham PLLC

20080064860 - Arginine derivative wash in protein purification using affinity chromatography: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising an arginine derivative, and collecting the product using... Agent: Wilmerhale/wyeth

20080064861 - Arginine wash in protein purification using affinity chromotography: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine, and collecting the product using an elution... Agent: Wilmerhale/wyeth

20080058503 - Electrical gripping testing and installation device: A method and apparatus for the safe and easy installation of wall-mounted electrical outlets and switches utilizing a multi-functional tool. Two different but similar tools are provided, each in the form of an insulated handle that may be detachably engaged with either a wall socket or a wall switch. The... Agent: Mark D Miller Kimble, Macmichael & Upton

20080058504 - Polymer-factor viii moiety conjugates: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.... Agent: Nektar Therapeutics

20080058505 - Pth functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules: Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1-34) fragment are disclosed that combine the N-terminal signaling domain (residues 1-9) and the C-terminal binding domain (residues 15-31) via a linker. Nucleic acid molecules and peptides for PTH(1-9)-(Gly)5-PTH(15-31) (PG5) and PTH(1-9)-(Gly)7-PTH(15-31) and a novel PTH receptor are disclosed. Additionally,... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080058506 - Method and device for marking biomolecules: The invention relates to a method which is used to efficiently mark proteins with the help of a micromixer, in addition to a device which enables said inventive method to be carried out in an economical manner and with additional auxiliary agents.... Agent: Norris, Mclaughlin & Marcus, Pa

20080058507 - Method for the removal of aggregate proteins from recombinant samples using ion exchange chromatography: The present invention relates to processes for the removal of unwanted protein aggregates from antibody preparations. One process involves removal when the aggregate and antibody are very close in pI value (“Bind-Elute” process). Another process involves the removal when the aggregate and antibody are very close in net electric charge... Agent: Nikolaos C. George Jones Day