Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 01/08

20080027211 - Enantiopure heterocyclic compound useful for the preparation of peptides which can be potentially used as medicaments: Enantiopure heterocyclic compound Enantiopure heterocyclic compound of formula (I) in which J is chosen from C, N, O and S; Z is H or a group for protecting the amino functional group, R3 denotes H or an organic residue, m is 0, 1 or 2 and n is 0, 1... Agent: Connolly Bove Lodge & Hutz, LLP

20080027212 - Methods and compositions for improved uptake of biological molecules: A “one-step” process for production of peptides and other organic molecules which are both esters and also acetylated forms of the desired molecule. The ester may be a mono-ester, di-ester, or another poly-ester, complexed with a molecule for protecting the organic molecules in the digestive tract. The method allows simple... Agent: Greenberg Traurig LLP (la)

20080027213 - Chimeric immunogens: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory... Agent: Sim & Mcburney

20080021196 - Inhibitors of memapsin 2 and use thereof: Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined. The substrate and subsite specificity information was used to design substrate analogs of the natural memapsin 2 substrate that can inhibit the function... Agent: Morrison & Foerster LLP

20080021195 - Substance capable of accelarating nucleotide chain exchange reaction: The purpose of the present invention is to provide a substance having a several ten to several hundred-fold exchange reaction accelerating activity as compared with that of conventional copolymers. In particular, the invention provides a preparation for accelerating an exchange reaction between a nucleotide sequence at specific site of a... Agent: Birch Stewart Kolasch & Birch

20080021197 - Novel processes for stereoselective synthesis of trans isatx247: The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1═H or D; R2═H or D; and R3═H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene... Agent: Nixon Peabody LLP - Patent Group

20080021198 - Modulators of protein phosphatase 2a and pp2a methyl esterase: The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A methyl esterase. The disclosure contained herein provides compounds and methods for identification of compounds that antagonize the function of PME, and thus reduce levels... Agent: Pepper Hamilton LLP

20080021199 - Methods for the specific preparation of lysobactin fragments: The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.... Agent: Morrison & Foerster LLP

20080021200 - Processes for preparing a polypeptide: The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of... Agent: Novartis Corporate Intellectual Property

20080021201 - Protease inhibitor conjugates and antibodies useful in immunoassay: Activated haptens useful for generating immunogen to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal... Agent: Marilyn L. Amick Roche Diagnostics Corporation

20080021202 - Novel apoptosis proteins: The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules... Agent: Townsend And Townsend And Crew, LLP

20080021203 - Process for preparing hybrid proteins: Hydrothermal processes are provided for preparing hybrid proteins containing altered SS/SH bonds, thereby yielding hybrid proteins having enhanced functional and/or nutritional properties. The processes involve initial homogenization of a protein-containing slurry containing at least two proteins, followed by high pressure steam treatment in a jet cooker (16) or similar device... Agent: Hovey Williams LLP

20080021204 - Process for removing water from aqueous solutions of proteins: A method for extracting water from an aqueous solution of a protein comprising the steps of: (a) intermixing the aqueous solution of the protein with a sufficient quantity of at least one glycol ether at a temperature at least 30 centigrade degrees above the lower critical solution temperature (LCST), preferably... Agent: The Dow Chemical Company

20080015337 - Protein belonging to the tnf superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080015338 - Individualized anti-cancer antibodies: The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used... Agent: Mchale & Slavin, P.A.

20080015339 - High affinity fibronectin derivatives: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20080015340 - Chimeric immunogens: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory... Agent: Sim & Mcburney

20080015341 - New hydrophobic polymer comprising fluorine moieties: A composite material having a support which is at least partially covered by a hydrophobic polymer comprising fluorine moieties obtainable by a process comprising the steps of contacting the support with a crosslinkable compound having at least one olefinic double bond until the support at its surface is at least... Agent: Jacobson Holman PLLC

20080009603 - Peptide analogues of gip for treatment of diabetes, insulin resistance and obesity: The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have enhanced resistance to degradation by the enzyme dipeptidyl peptidase IV (DPP IV). The invention also provides a process of N terminally modifying GIP and... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham)

20080009604 - Novel polypeptide and process for producing the same: Wherein “X” represents H or the group HOOC—(CH2)m—CO— (“m”=1 to 18), “Y” represents Pro or Hyp, “n”=1 to 20, “Z” represents a peptide chain comprising 1 to 10 amino acid residue(s), “r”=1 to 20, and “R” represents a linear or branched alkylene group. The present invention provides a collagenous polypeptide... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080009605 - P49/strap is a novel protein involved in gene regulation and cell proliferation: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in... Agent: Cyr & Associates, P.A.

20080009606 - Polysaccharides and protein conjugate, and emulsifiers and emulsions containing it: Emulsifying agents of the natural polvymer type, especially polysaccharide type, attain excellent emulsion stability and give a stable emulsion. However, their emulsifying power is not always high and these emulsifying agents have been still insufficient in giving an emulsion having a small particle diameter. A polymer-type emulsifying agent is provided... Agent: Paul And Paul

20080009607 - Antibodies to sulfated carbohydrates: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to chondroitin sulfate, particularly CS-A, CS-C and CS-E tetrasaccharides. The present invention also relates to methods of making anti-CS antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and... Agent: Knobbe Martens Olson & Bear LLP

20080009609 - Cloning and sequencing of pyruvate decarboxylase (pdc) genes from bacteria and uses therefor: The invention provides isolated nucleic acids molecules which encode pyruvate decarboxylase enzymes having improved decarboxylase activity, substrate affinity, thermostability, and activity at different pH. The nucleic acids of the invention also have a codon usage which allows for high expression in a variety of host cells. Accordingly, the invention provides... Agent: Edwards Angell Palmer & Dodge LLP

20080009608 - Sitosterolemia susceptibility gene (ssg): compositions and methods of use: The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the... Agent: Jones Day

20080009610 - Diagnosis and treatment of ptp related disorders: The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for PTP05 and/or... Agent: Foley And Lardner LLP Suite 500

20080009611 - Method for producing protein hydrolysates: The aim of the invention is to provide a method for producinprotein hydrolysates that have defined molecular weight limits without carrying out enzymatic or pH-adjusting process steps. For this purpose, the method for producing protein hydrolysates from proteinaceous plant and animal materials is characterized by splitting the materials up in... Agent: Pearl Cohen Zedek Latzer, LLP