Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 10/07

20070249805 - Clay-binding peptides and methods of use: Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070249806 - Solid phase fmoc chemistry process to prepare peptides: The present invention relates to an improved process for the preparation of N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(16)-disulfide of formula (1), which involves assembling a peptide chain comprising of six amino acids and a thioalkyl carboxylic acid in a required sequence on a solid support to obtain a peptide bound resin of formula (2),... Agent: Pharmaceutical Patent Attorneys, LLC

20070249808 - Multiple sclerosis-related superantigen: The invention relates to a protein or peptide having superantigen (SAg) activity, said protein or peptide comprising the ENV protein of the human endogenous retrovirus HERV-W, the surface protein (SU) and transmembrane (TM) sub-units thereof, and fragments of HERV-W ENV and its subunits, particularly C-terminal fragments, which possess superantigen activity.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070249807 - Prevention and reduction of blood loss: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary... Agent: Fish & Richardson PC

20070249810 - Method to protect dna ends: A method of protecting the 3′ end of a DNA molecule from nuclease damage is disclosed. In one embodiment, the method comprises the step of exposing the DNA molecule to a preparation of DdrA protein.... Agent: Quarles & Brady LLP

20070249809 - Protein engineering with analogous contact environments: The invention relates to novel methods for engineering protein sequences using structural and homology information.... Agent: Morgan, Lewis & Bockius, LLP

20070249811 - Method for producing and purifying gelatin: This invention relates to a method for purifying a gelatin solution obtained in a continuous process from raw material consisting of fresh defatted bone material from pig, cattle, sheep or chicken, which method comprises the steps of grinding the raw material, optionally with addition of water, mixing the ground raw... Agent: Buchanan, Ingersoll & Rooney PC

20070249813 - Human antibodies that bind human tnfa: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in... Agent: Lahive & Cockfield, LLP

20070249812 - Methods for stabilizing protein solutions: The present inventors examined use of citric acid buffers for suppressing cryoprecipitation of IgM at a pH range and salt concentration suitable for storing IgM. As a result, the present inventors discovered that citric acid buffers significantly suppress cryoprecipitation.... Agent: Fish & Richardson PC

20070249814 - Transcriptional regulatory factor: BLAST search was done on the EST database by using various nucleotide sequences encoding known bromodomain motifs to discover several ESTs likely encoding bromodomain genes. Next, testicular cDNAs were PCR cloned by using primers designed based on the sequence of EST (W17142), which is one of the ESTs discovered above.... Agent: Fish & Richardson PC

20070249815 - Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue: A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and... Agent: Williams, Morgan & Amerson

20070244297 - Human calcium channel compositions and methods: Isolated DNA encoding each of human calcium channel α1-, α2-, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.... Agent: Merck And Co., Inc

20070244298 - Monomeric red fluorescent proteins: Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use.... Agent: Michael Best & Friedrich LLP

20070244299 - Method of stabilizing proteins: A method of preparing a stabilized bulk solution of a monomeric protein is described, which consists in providing a bulk of monomeric protein in a buffer solution and adding an excipient to the bulk, wherein the excipient is selected from the group consisting of bacteriostatic agents, surfactants, isotonicity agents, amino... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070244300 - Novel canola protein isolate: A novel canola protein isolate consisting predominantly of 2S canola protein and having improved solubility properties, has an increased proportion of 2S canola protein and a decreased proportion of 7S canola protein. The novel canola protein isolate is formed by heat treatment of aqueous supernatant from canola protein micelle formation... Agent: Sim & Mcburney

20070244301 - Pegylated factor viii: The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least... Agent: Baxter Healthcare Corporation

20070244302 - Antibodies and methods for generating genetically altered antibodies with high affinity: Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of... Agent: Woodcock Washburn LLP

20070244303 - Cd16a binding proteins and use for the treatment of immune disorders: CD16A binding proteins useful for the reduction of a deleterious immune response are described. In one aspect, humanized anti-cd16A antibodies, optionally lacking effector function, are used for the treatment of immune disorders such as idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.... Agent: King & Spalding

20070244304 - Methods of identifying neoplasm-specific antibodies and uses thereof: The present invention features methods of identifying, from healthy donors, polypeptides, such as antibodies, that are specific for neoplasm, polypeptides identified using such methods, and their use in the treatment and diagnosis of neoplasms.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070244305 - Process for the manufacture of virus safe immunoglobulin: Process for preparing a purified immunoglobulin preparation. The process comprises the steps of subjecting a crude immunoglobulin solution to caprylic acid treatment, removing protein aggregates and viruses from the immunoglobulin solution, subjecting the immunoglobulin solution to anion exchange chromatography in order to purify the immunoglobulin, filtering the immunoglobulin solution thus... Agent: Sughrue Mion, PLLC

20070244306 - Fractionator and method of fractionation: The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized... Agent: Birch Stewart Kolasch & Birch

20070244307 - Chromatography ligand: The present invention relates to a chromatography ligand defined by the following formula (I) R1—R2—N(R3)—R4—R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070238860 - Method for refolding a protein: A method for refolding a protein by mixing a protein solution with a refolding buffer at mixing conditions that approximate ideal mixing. The method can be carried out batch wise, in a fed-batch mode or continuously with on-line solubilization of inclusion bodies.... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070238859 - Pro9925 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.

20070238861 - Ribonucleases and methods of making them recombinantly: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.... Agent: Mark H. Jay, P.A.

20070238862 - Compositions and methods comprising a ligand of chemerinr: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070238863 - Reagent and method for detecting a cryptosporidium parvum sporozoite antigen: A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in which the antibody is used to detect or quantify C. parvum sporozoite antigen in a... Agent: Centers For Disease Control C/o Needle & Rosenberg P.C.

20070238864 - Multidimensional protein separation: In large scale proteome applications, protein separation is paramount to observing discrete changes and quantitative evaluation must coincide with qualitative protein identification for effective differential analysis. A four dimensional (4D) platform for resolving and differentially analyzing complex biological samples is presented. The system, collectively termed CAX-PAGE/RPLC-MSMS, combines bi-phasic ion-exchange chromatography... Agent: Akerman Senterfitt

20070232786 - Acrylated maleic-modified rosin ester and method of preparation: A two-step method for introducing acrylic functions into high molecular weight natural resins, under mild conditions, without the risk of gellation, wherein an acrylated natural resin ester is prepared by esterifying one or more of the sterically hindered hydroxy groups of the natural resin ester in an inert solvent with... Agent: Dickstein Shapiro

20070232787 - Method for producing type iv collagen: An object of the invention is to provide type IV collagen without contamination by other proteins and without degradation or denaturation. The present invention provides a type IV collagen which is derived and extracted from lens capsules without the use of an enzyme and has a minimum molecular weight of... Agent: Birch Stewart Kolasch & Birch

20070232788 - Factor viii compositions and methods: The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor... Agent: Sughrue Mion, PLLC

20070232789 - Factor viii compositions and methods: The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor... Agent: Sughrue Mion, PLLC

20070232790 - Production of anti-self antibodies from antibody segment repertoires and displayed on phage: Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface... Agent: Howrey LLP

20070232791 - Hemostatically active vwf-containing preparation and process for the preparation thereof: A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of... Agent: Jacobson Holman PLLC

20070232792 - Method for the production of recombinant peptides with a low amount of trisulfides: Methods for the production of recombinant peptides comprise fermenting cells to produce recombinant peptides. A metal salt is added to a concentrate of the fermented cells after the fermentation step, prior to peptide isolation, thereby reducing the amount of trifulsides formed in the production of the recombinant peptide. In one... Agent: Dinsmore & Shohl, LLP

20070232793 - Functional molecule and manufacturing method therefor: A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule manufactured by this method. The method for manufacturing a functional molecule includes binding, to a resin, a specific substance having a cleavable linker which is a site that... Agent: Kratz, Quintos & Hanson, LLP